Can PEP‐3 Provide a Cognitive Profile in Children with ASD? A Comparison Between the Developmental Ages of PEP‐3 and IQ of Leiter‐R

Giacomo, Andrea De; Craig, Francesco; Cristella, Arcangelo; Terenzio, Vanessa; Buttiglione, Maura; Margari, Lucia

doi:10.1111/jar.12216

Cited by 13 publications

(7 citation statements)

References 20 publications

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“… The PEP-3 development workup revealed global delay, which suggests a very probable intellectual deficit in this child. The development levels in the PEP are considered good indicators of cognitive functioning in both verbal and nonverbal children [ 27 ]. Our patient workup revealed that her oculomotor imitation was better than her global and fine motor skills, while the majority of children with ASD habitually have more difficulties in the domain of imitation than in motor skills [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

An atypical autistic phenotype associated with a 2q13 microdeletion: a case report

et al. 2018

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BackgroundAutism spectrum disorders are serious neurodevelopmental disorders that affect approximately 1% of the population. These disorders are substantially influenced by genetics. Several recent linkage analyses have examined copy number variations associated with autism risk. Microdeletion of the 2q13 region is considered a pathogenic copy number variation. This microdeletion is involved in developmental delays, congenital heart defects, dysmorphism, and various psychiatric disorders, including autism spectrum disorders. There are only 34 reported cases with this chromosomal deletion, and five cases of autism spectrum disorders have been identified among them. The autistic phenotype associated with this microdeletion has never been described.Case presentationWe describe the case of a 44-month-old Caucasian girl with the 2q13 microdeletion and autism spectrum disorders with global development delay but no associated organ anomalies. We examined the autistic phenotype using different workups and observed an atypical phenotype defined by relatively preserved relational competency and imitation abilities.ConclusionsThe main contribution of this case report is the precise description of the autistic phenotype in the case of this deletion. We observed some atypical clinical features that could be markers of this genetic anomaly. We have discussed the pathophysiology of autism associated with this microdeletion and its incomplete penetrance and variable expressivity.

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Section: Discussionmentioning

confidence: 99%

An atypical autistic phenotype associated with a 2q13 microdeletion: a case report

et al. 2018

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“…PEP-3 [ 18 , 19 ], specifically designed for children with ASD, was used to estimate the development of communication and motor skills as well as maladaptive behaviors. The PEP-3 was proposed as an assessment tool to evaluate the treatment effects of the TEACCH.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial

et al. 2016

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Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial and participated in three months of structured teaching. Forty-four children were treated with 400 μg folic acid (two times/daily) for a period of three months during their structured teaching (intervention group), while the remaining 22 children were not given any supplement for the duration of the study (control group). The Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile-third edition (PEP-3) were measured at the beginning and end of the treatment period. Folic acid, homocysteine, and glutathione metabolism in plasma were measured before and after treatment in 29 autistic children randomly selected from the intervention group and were compared with 29 age-matched unaffected children (typical developmental group). The results illustrated folic acid intervention improved autism symptoms towards sociability, cognitive verbal/preverbal, receptive language, and affective expression and communication. Furthermore, this treatment also improved the concentrations of folic acid, homocysteine, and normalized glutathione redox metabolism. Folic acid supplementation may have a certain role in the treatment of children with autism.

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“…One validation study conducted in Canada (Fulton and D’Entremont 2013 ) revealed positive correlations between the PEP-3 intellectual and language measures and those measuring similar domains (e.g., the Child Development Inventory) among 136 children with ASD aged between 20 and 75 months. A more recent study (De Giacomo et al 2016 ) also detected a positive correlation between PEP-3 cognitive developmental levels and non-verbal IQ, measured by the Leiter International Performance Scale-Revised among 30 Italian children with ASD. However, these studies only focused on some subtests of the PEP-3 and were thus unable to provide comprehensive psychometric evidence for the translated instrument on the whole.…”

Section: Introductionmentioning

confidence: 79%

Validation of the Simplified Chinese Psychoeducational Profile Third Edition in Mainland China

Zhu

Shek

et al. 2018

J Autism Dev Disord

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The Psychoeducational Profile 3rd Edition (PEP-3) is a comprehensive assessment tool designed for children with autism spectrum disorder (ASD). Although its original English version has been validated, few validation studies have been conducted on translated versions including Chinese ones. Based on 554 Chinese children with ASD and 311 typically developing Chinese children as the control group, this study investigated the psychometric properties of a simplified Chinese PEP-3 (sCPEP-3) in China mainland. Psychometric evaluation of the sCPEP-3 showed satisfactory internal consistency, test–retest reliability, inter-rater reliability, convergent validity, construct validity, and factorial validity. The findings have several implications such as utilizing the sCPEP-3 in mainland China for customized educational program planning, early identification, and evaluating the treatment effects for children with ASD. Electronic supplementary material The online version of this article (10.1007/s10803-018-3827-z) contains supplementary material, which is available to authorized users.

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Can PEP‐3 Provide a Cognitive Profile in Children with ASD? A Comparison Between the Developmental Ages of PEP‐3 and IQ of Leiter‐R

Abstract: These findings show that the DLs could be considered as indicators of cognitive functioning in ASD.

Cited by 13 publications

References 20 publications

An atypical autistic phenotype associated with a 2q13 microdeletion: a case report

An atypical autistic phenotype associated with a 2q13 microdeletion: a case report

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial

Validation of the Simplified Chinese Psychoeducational Profile Third Edition in Mainland China

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