Can Platelet Count and Platelet Indices Predict the Risk and the Prognosis of Preeclampsia?

Doğan, Keziban; Güraslan, Hakan; Şentürk, Mehmet Baki; Helvacıoğlu, Çağlar; İdil, Sevda; Ekin, Murat

doi:10.3109/10641955.2015.1060244

Cited by 55 publications

(80 citation statements)

References 15 publications

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“…Recently, Doğan et al14 observed significantly lower PC and PC/MPV in preeclamptic women compared with the controls. The same study documented significantly higher MPV in preeclamptic women than the control group.…”

Section: Discussionmentioning

confidence: 96%

Platelet count and platelet indices in women with preeclampsia

Al-Sheeha¹,

Alaboudi²,

Al-Ghasham³

et al. 2016

VHRM

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BackgroundAlthough the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia.ObjectiveTo compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls.SettingQassim Hospital, Kingdom of Saudi Arabia.DesignA case–control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls.ResultsThere was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC) curves, the PC cutoff was 248.0×103/µL for diagnosis of pre-eclampsia (P=0.019; the area under the ROC curve was 62.4%). Binary regression suggests that women with PC <248.010×103/µL were at higher risk of preeclampsia (odds ratio =2.2, 95% confidence interval =1.08–4.6, P=0.03). The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia (P=0.035, the area under the ROC curve was 62.2%).ConclusionPC <248.010×103/µL and PC to MPV ratio 31.2 are valid predictors of preeclampsia.

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Section: Discussionmentioning

confidence: 96%

Platelet count and platelet indices in women with preeclampsia

Al-Sheeha¹,

Alaboudi²,

Al-Ghasham³

et al. 2016

VHRM

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Section: Discussionmentioning

confidence: 99%

“…17) A previous report suggested that increased platelet turnover caused by endothelial injury may be one of the reasons for the lower platelet count. 17) Once preeclampsia is complicated by HELLP syndrome, consumption of platelets may increase and promote hemorrhagic tendency. Although thrombocytopenia is defined as a platelet count less than 100,000/ μl according to the diagnostic standard proposed by Sibai et al, 18) the results of the present study suggest that preeclamptic women should be recognized as being at high risk for bleeding complications by anticoagulant therapy even when preoperative platelet counts are not abnormally low.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for bleeding complications of postoperative prophylactic anticoagulation therapy after cesarean section in preeclampsia cases

Tsujimoto

Hyodo

Sunagawa

et al. 2018

Hypertens Res Pregnancy

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Aim: This study aimed to identify risk factors for bleeding complications of postoperative prophylactic anticoagulation after cesarean section in preeclampsia cases. Methods: A total of 68 cases of preeclampsia or superimposed preeclampsia at a tertiary perinatal center in Tokyo between 2012 and 2017 were recruited for this study. Bleeding complications were defined as subcutaneous, subfascial, or intraperitoneal hematoma detected by ultrasonography or computed tomography. Associations of clinical and laboratory data with bleeding complications were assessed by univariate and multivariate analyses. Results: Bleeding complications were recorded in nine cases: subcutaneous hematoma in four cases, subfascial hematoma in four cases, and intraperitoneal hematoma in one case. Univariate analysis revealed preoperative platelet count and 24-h urine protein level to be associated with bleeding complications. Moreover, multivariate logistic regression analysis revealed preoperative platelet count (odds ratio, 0.867; 95% confidential interval, 0.756-0.994; P = 0.04) and 24-h urine protein level (odds ratio, 1.498; 95% confidential interval, 1.031-2.176; P = 0.03) to be independent risk factors for bleeding complications. Conclusion: Preoperative platelet count and 24-h urine protein level may help to identify patients at increased risk for bleeding complications.Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of maternal morbidity and mortality in Japan.1) Not only pregnancy itself, but other factors during pregnancy and postpartum increase the risk of VTE. Among these, cesarean section is one of the most important risk factors.2) In Japan, the incidences of DVT and PE after cesarean section are 0.04% and 0.06%, respectively, and cesarean section increases the risk of developing DVT and PE by 5-and 22-fold, respectively.2,3) As cesarean section has become more common in Japan, preventing VTE after the procedure is becoming all the more important.Preeclampsia, a clinical entity included in hypertensive disorders of pregnancy (HDP), is characterized by hypertension, proteinuria, and multiple organ complications. Although the exact pathogenesis of preeclampsia is still unknown, it is thought to involve endothelial dysfunction resulting from an imbalance of pro-angiogenic and anti-angiogenic factors.4) As maternal endothelial damage activates the coagulation system, cesarean section in preeclampsia may increase the risk of VTE. 5) Consideration of prophylactic anticoagulation therapy for women with preeclampsia after cesarean section is recommended by the guidelines of the Japan Society of Obstetrics and Gynecology (JSOG) and 1 Hypertension Research in Pregnancy

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“…En investigaciones previas se ha reportado que los valores son de 78% -90% para la sensibilidad y 83% -86% para la especificidad 10 . En la preeclampsia postparto también se han encontrado que el volumen plaquetario medio es significativamente más alto en las preeclámpticas comparado con las embarazadas normotensas 30 .…”

Section: Discussionunclassified

Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia

Rondón-Tapía

Mejia-Montilla

Reyna-Villasmil

et al. 2018

Rev. chil. obstet. ginecol.

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Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia. RESUMENOBJETIVO: Establecer la utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia. MÉTODOS: Se realizó un estudio de de casos y controles en el Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Se seleccionó un total de 180 embarazadas. Se incluyeron 90 preeclámpticas como grupo de estudio (grupo A) y un grupo de control seleccionado por tener edad e índice de masa corporal similares al grupo de estudio, que consistió en 90 embarazadas normotensas sanas (grupo B). Las muestras de sangre se recolectaron en todas las pacientes antes del parto e inmediatamente después del diagnóstico en el grupo A, para determinar los valores de volumen plaquetario medio. Se determinaron las características generales, valores de volumen plaquetario medio y eficacia diagnóstica. RESULTADOS: Se encontraron diferencias estadísticamente significativas en los valores de volumen plaquetario medio entre las pacientes del grupo A (10,35 +/-1,11 fL) y las pacientes del grupo B (9,54 +/-0,96 fL; p < 0,001). No se observaron correlaciones significativas con los valores de presión arterial sistólica y diastólica (p = ns). Un valor de corte de 10,3 fL presentó un valor por debajo de la curva de 0,71, sensibilidad del 53,3%, especificidad del 63,1%, valor predictivo positivo del 63,2% y valor predictivo negativo del 59,6%, con una exactitud diagnóstica del 61,1%. CONCLUSIÓN: Los valores volumen plaquetario medio no son útiles para discriminar el diagnóstico de preeclampsia en las embarazadas, a pesar que las preeclámpticas presentaron valores significativamente más elevados de al compararlo con embarazadas normotensas sanas.

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Can Platelet Count and Platelet Indices Predict the Risk and the Prognosis of Preeclampsia?

Cited by 55 publications

References 15 publications

Platelet count and platelet indices in women with preeclampsia

Platelet count and platelet indices in women with preeclampsia

Risk factors for bleeding complications of postoperative prophylactic anticoagulation therapy after cesarean section in preeclampsia cases

Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia

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