Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?

Korkmaz, Levent; Baştuğ, Osman; Özdemır, Ahmet; Ceylan, Mahir; Güneş, Tamer; Öztürk, Mehmet; Korkut, Sabriye

doi:10.1055/s-0038-1676535

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…On the other hand, Dani et al, also suggested that elevated MPV at 24 to 48 h of life was higher in BPD than in non-BPD groups, however, there was no significant difference of MPV between IVH and non-IVH groups (12). Korkmaz et al also suggested that platelet counts, MPV, and PMI at 12 h postpartum were not associated with IVH (26). In this study, PCT is an independent risk factor for IVH.…”

Section: Discussionmentioning

confidence: 41%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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Background: Platelets participate in many physiological and pathological functions and some platelet parameters predict adult diseases. However, few studies report whether platelet parameters may reflect neonatal disease and mortality in a large cohort.Objective: We aimed to investigate whether platelet parameters could predict bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and NICU mortality. Study Design and Methods:This retrospective cohort study examined records from 2006 to 2017 at the neonatal intensive care unit (NICU) of Fukushima Medical University Hospital. We retrospectively investigated platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) on the first day of life in preterm newborns born <32 weeks' gestation admitted to our NICU from 2006 to 2017. Receiver operating characteristic (ROC) and multiple regression analyses, along with Cox proportional hazard modeling, identified independent predictors of morbidities and mortality in preterm newborns.Results: Of 1,501 neonates admitted to our NICU, a total of 305 preterm newborns were included in this study. Gestational age, birth weight, and Apgar score were significantly lower in non-survivors than in survivors. Platelet count, PCT, PDW and PMI did not differ significantly between the two groups, whereas mean MPV in non-survivors was significantly higher than in survivors (10.5 fl vs. 10.0 fl, p = 0.001). Multivariate Cox hazard modeling showed that shorter GA [HR: 0.628, 95% CI: 0.464-0.840, p = 0.003], male sex [HR: 0.269, 95% CI: 0.113-0.640, p = 0.001], and MPV [HR: 1.469, 95% CI: 1.046-2.063, p = 0.026] independently predicted overall survival. Per receiver operating curve, an MPV threshold of 10.2 fl. MPV predicts prognosis in neonates with a sensitivity of 72.4% and a specificity of 58.6% (AUC = 0.685, 95% CI: 0.600-0.789, p = 0.001). Furthermore, multivariate analysis revealed that platelet parameters were not associated Go et al. Platelet Parameters in Neonateswith BPD and NEC, whereas small for gestational age (SGA), Apgar score at 5 min, and low PCT were associated with intraventricular hemorrhage (IVH).Conclusion: This study demonstrates that low PCT predicts IVH, and MPV ≥ 10.2 fL correlates with mortality among infants born after <32 weeks' gestation.

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Section: Discussionmentioning

confidence: 41%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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“…Increased (> 13 fL) mean platelet volume (MPV) has been associated with hemorrhagic stroke, when compared to controls; nevertheless, neither MPV nor PLT were associated with outcome prognosis [16]. Platelet mass index (PMI), which is the product of PLT and MPV, has been proposed as predictor of intraventricular hemorrhage in very-low birth-weight newborns [17].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the emerging evidence that platelets are contributing to the risk for ICH, their role remains partly understood. On the other hand, it is known that alterations of PLT and platelet indices including MPV, platelet distribution width (PDW), and platelet large cell ratio (P-LCR; the percentage of platelets with volume > 12 fL) are observed in platelet activation, consumption and replenishment [17].…”

Section: Introductionmentioning

confidence: 99%

The day after intracerebral hemorrhage: platelet mass index as predictor of survival—a retrospective cohort study

Avramidou,

Goulimari,

Stergiou

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Background Platelets are implicated in the pathophysiology of intracerebral hemorrhage (ICH). Platelet count (PLT) is affected by platelet loss, while mean platelet volume (MPV) by platelet replenishment. Whether platelet mass index (PMI), the product of PLT and MPV, might predict survival after ICH, remains unknown. Methods All first-ever ICH patients, admitted to Xanthi General Hospital between January 2018 and May 2020 and met eligibility criteria, were enrolled in this retrospective cohort study. Demographics, medical record, first-symptom-to-admission time, vital signs, modified Rankin Scale, ICH score, arterial blood gas test, complete blood count, blood biochemistry, and CT scan test were collected for each patient. PMI values on day 1 (admission; PMI1), day 2 (PMI2), and day 7 (PMI7), along with PLT, MPV, platelet distribution width (PDW), and platelet large cell ratio (P-LCR), were evaluated as potential predictors of 12-month survival using Repeated Measures General Linear Model. Binary discretization of predictors was based on optimal scaling and evaluated using binary regression. Results From 59 patients enrolled (aged 75.7 ± 12.0 years; 31 females), 29 were still alive 12 months after ICH. Age, arterial hypertension, diabetes mellitus, hemoglobin level (Hb), and oxygen saturation (O2Sat) were correlated with 12-month survival. After adjustment for these parameters, PMI1 and PMI2 were independently correlated with 12-month survival (P = 0.048 and P = 0.004, respectively), while PMI7 was not (P = 0.332). PMI2 ≥ 2,400 fL/μL was best to discriminate survivors from non-survivors (age, arterial hypertension, diabetes mellitus, Hb, and O2Sat adjusted OR 0.123 with 95% CI: 0.023–0.694; P = 0.018). Conclusions PMI within the first day after admission for ICH might be used as early predictors of survival. Properly designed prospective studies are needed to further evaluate their contribution as such.

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“…Whole blood indices related to platelets, which are indicators of inflammation in the neonatal period, have been evaluated in relation to neonatal and especially preterm morbidities. There are studies suggesting that there is an association between platelet-related markers including platelet mass index, mean platelet volume and IVH (11). Here, TLR was calculated in whole blood samples collected at the first hospitalization of preterm infants younger than 28 weeks, and the relationship between IVH was to be investigated.…”

Section: Introductionmentioning

confidence: 99%

İleri derecede immatür bebeklerde trombosit lenfosit oranları (TLO) ile ağır intraventriküler hemoraji (IVH) ilişkisi

Silahli¹

2022

Genel Tıp Dergisi

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Aim: Intraventricular hemorrhage (IVH) is a serious complication of premature births, especially in newborns with very low birth weight. It's important to be able to predict IVH. In this study, the relationship between thrombocyte lymphocyte ratio (TLR) and intraventricular hemorrhage in premature infants born under 28 weeks was examined. Material and methods: In the last 5 years, the medical records of infants with less than 28 weeks of gestational age (n=78) born in our hospital have been retrospectively examined. Obtained parameters from the whole blood count, especially the relationship between TLR and IVH were examined. Results: White blood cell and lymphocyte counts were significantly higher in severe IVH (grade 3-4), while TLR was found to be significantly lower (16048±5265 & 11972±10915, p=0.043; 10705±4537 & 6329±8101, p=0.007; 36.9±22.7 & 56.7±37.9 p=0.012, respectively). When the white blood cell, lymphocyte count, and TLR's diagnostic performance in predicting severe IVH were evaluated by ROC curve analyses, it was observed that the strongest performance belonged to the TLR (Area under the curve, AUC for WBC: 0.644; ALS: 0.687; TLR: 0,691, respectively). TLR can estimate severe IVH with 94% sensitivity and 43% specificity at a cut-off value below 55.84. Conclusion: TLR can be used as a valuable marker for predicting IVH in extremely premature infants. Keywords: Intraventricular hemorrhage; platelet lymphocyte ratio; premature infants. ÖZ Amaç: İntraventriküler hemoraji (IVH), özellikle çok düşük doğum ağırlıklı yeni doğanlarda prematüre doğumların ciddi bir komplikasyonudur. IVH'yi tahmin edebilmek oldukça önemlidir. Bu çalışmada 28 hafta altında doğan prematüre bebeklerde doğumda bakılan trombosit lenfosit oranı (TLO) ve intraventriküler hemoraji (IVH) arasındaki ilişki incelenmek istenmiştir. Gereç ve yöntem: Son 5 yılda hastanemizde yatan 28 hafta altı prematüre bebeklerin (n=78) dosyaları geriye dönük incelendi. Doğum sonrası bakılan tam kan verilerinden elde edilen parametreler ve özellikle TLO ve IVH arsındaki ilişki incelendi. Bulgular: Beyaz küre ve lenfosit sayıları ciddi IVH'de (grade 3-4) anlamlı yüksek bulunurken, TLO anlamlı düşük bulunmuştur (sırasıyla 16048±5265 & 11972±10915,

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Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?

Cited by 6 publications

References 37 publications

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

The day after intracerebral hemorrhage: platelet mass index as predictor of survival—a retrospective cohort study

İleri derecede immatür bebeklerde trombosit lenfosit oranları (TLO) ile ağır intraventriküler hemoraji (IVH) ilişkisi

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