Can Postbiotics Represent a New Strategy for NEC?

Giannì, Maria Lorella; Morniroli, Daniela; Mosca, Fabio; Rescigno, Maria

doi:10.1007/978-3-031-58572-2_3

Advances in Experimental Medicine and Biology

2024

DOI: 10.1007/978-3-031-58572-2_3

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Can Postbiotics Represent a New Strategy for NEC?

Maria Lorella Giannì,

Daniela Morniroli,

Fabio Mosca

et al.

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2024

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Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review

Provitera,

Tomaselli,

Algieri

et al. 2024

Metabolites

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Background: Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that occurs predominantly in premature infants and is characterized by the inflammation and necrosis of the intestine, showing high morbidity and mortality rates. Despite decades of research efforts, a specific treatment is currently lacking, and preventive strategies are the mainstays of care. This review aims to help understand the complex interplay between gut microbiota and their metabolites in NEC pathogenesis. In particular, we focused on how these factors can influence gut health, immune responses, and intestinal barrier integrity. Discussion: Current research has increasingly focused on the role of the gut microbiota and their metabolites in NEC pathogenesis, thanks to their involvement in modulating gut health, immune responses, and intestinal barrier integrity. Conclusions: A deeper understanding of the interplay between gut microbiota and their metabolites is essential for developing personalized strategies to prevent NEC. By targeting these microbial interactions, new therapeutic approaches may emerge that offer improved outcomes for preterm infants at a high risk of NEC.

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Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review

Provitera,

Tomaselli,

Algieri

et al. 2024

Metabolites

View full text Add to dashboard Cite

show abstract

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Can Postbiotics Represent a New Strategy for NEC?

Cited by 1 publication

References 87 publications

Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review

Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review

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