Can proteomics predict the prognosis in chronic dioxin intoxication?

Pelclová, Daniela; Talacko, Pavel; Navrátil, Tomáš; Zámostná, Blanka; Fenclová, Zdeňka; Vlčková, Štěpánka; Zakharov, Sergey

doi:10.1007/s00706-019-02460-0

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Proteomic analysis of biological samples, such as blood serum and urine, is an important research tool in humans for obtaining new data (38,39). Methanol metabolites induce alterations in proteins by damaging the blood-brain barrier, brain structures, optic nerve, retina, and blood-retinal barrier (40).…”

Section: Proteomics Profile In Methanol Poisoningmentioning

confidence: 99%

Introducing a Possible Proteomic and Genomic Biomarker Panel Related to Methanol Poisoning: A Review

Ahmadzadeh,

Bagheri,

Mostafazadeh

et al. 2024

J Cell Mol Anesth

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Context: Methanol is one of the simplest organic compounds widely used in industry. It is highly toxic and unfit for human consumption. The abuse of methanol-containing beverages is becoming a severe health problem. This review discusses new clinical and pathological manifestations alongside proteomic and genomic changes based on methanol's toxic effects. Evidence Acquisition: Medical literature was reviewed in Google Scholar, Scopus, and PubMed to examine the effect of methanol intoxication on proteomic and genomic changes in the human body. Results: The results revealed the rapid direct absorption of methanol and its spread in body tissues. Various side effects, from digestive problems to neurological disorders, blindness, and death, could occur depending on the consumed dosage. Methanol poisoning causes extensive changes at the protein level, affecting blood coagulation, vitamin metabolism, immune response, and lipid transport processes. Methanol could alter the gene expression profile pattern by increasing the production of free radical species, which cause changes in DNA nucleotides. Conclusions: In conclusion, since methanol poisoning is associated with serious adverse effects (protein expression changes) and mortality, it should be managed seriously and promptly.

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Section: Proteomics Profile In Methanol Poisoningmentioning

confidence: 99%

Introducing a Possible Proteomic and Genomic Biomarker Panel Related to Methanol Poisoning: A Review

Ahmadzadeh,

Bagheri,

Mostafazadeh

et al. 2024

J Cell Mol Anesth

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“…Proteomic analysis of biological matrices, such as blood serum, urine, and exhaled breath condensate, is an important research tool in human and clinical toxicology that brings new data 27 , 28 . Serum proteomics can reflect systemic and target organ impairments and confirm specific modifications to selected proteins.…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic blood serum proteome changes in patients with methanol poisoning

Cejnar

Smirnova

Kučková

et al. 2022

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Twenty-four blood serum samples from patients with acute methanol poisoning (M) from the mass methanol poisoning outbreak in the Czech Republic in 2012 were compared with 46 patient samples taken four years after poisoning (S) (overlap of 10 people with group M) and with a control group (C) of 24 samples of patients with a similar proportion of chronic alcohol abuse. When comparing any two groups, tens to hundreds of proteins with a significant change in concentration were identified. Fifteen proteins showed significant changes when compared between any two groups. The group with acute methanol poisoning showed significant changes in protein concentrations for at least 64 proteins compared to the other groups. Among the most important identified proteins closely related to intoxication are mainly those involved in blood coagulation, metabolism of vitamin A (increased retinol-binding protein), immune response (e.g., increased complement factor I, complement factors C3 and C5), and lipid transport (increased apolipoprotein A I, apolipoprotein A II, adiponectin). For blood coagulation, the most affected proteins with significant changes in the methanol poisoning group were von Willebrand factor, carboxypeptidase N, alpha-2-antiplasmin (all increased), inter-alpha-trypsin inhibitor heavy chain H4, kininogen-1, plasma serine protease inhibitor, plasminogen (all decreased). However, heparin administration used for the methanol poisoning group could have interfered with some of the changes in their concentrations. Data are available via ProteomeXchange with the identifier PXD035726.

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Can proteomics predict the prognosis in chronic dioxin intoxication?

Cited by 2 publications

References 32 publications

Introducing a Possible Proteomic and Genomic Biomarker Panel Related to Methanol Poisoning: A Review

Introducing a Possible Proteomic and Genomic Biomarker Panel Related to Methanol Poisoning: A Review

Acute and chronic blood serum proteome changes in patients with methanol poisoning

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