Can SARS-CoV-2 trigger reactive arthritis?

Arthritis in a Child with COVID-19-Related Multisystemic Inflammatory Disease - A Case Report

“…Jali describes a patient with arthritis in the small joints of the hands, however, in this case the patient was a 39-year-old woman whose arthritis also presented three weeks after the initial infection, and both the proximal and distal interphalangeal joints were affected. The only minor described above was a 16-year-old girl with dactylitis, also with onset three weeks after the initial infection [7]. There are a few reports of onset of arthritis during the initial phase of the infection.…”

“…Joint involvement is even less frequent, and, where described, is poorly characterized with descriptions such as "joint pain", and "arthritis or arthralgia" [11,15,18]. Whereas arthritis has been described in the context of COVID-19 infection, to our knowledge none have been in MIS-C, and only one in a minor [7]. Several authors have described a clinical picture of reactive arthritis, with the presentation of arthritis 8 to 25 days after the initial infection [7,19,20] (Parisi -Langhoff).…”

“…Whereas arthritis has been described in the context of COVID-19 infection, to our knowledge none have been in MIS-C, and only one in a minor [7]. Several authors have described a clinical picture of reactive arthritis, with the presentation of arthritis 8 to 25 days after the initial infection [7,19,20] (Parisi -Langhoff). All of these patients had involvement of joints in the lower members, typical for reactive arthritis, although none describe positivity of HLA-B27.…”

“…These include, but are not limited to, cutaneousv [2], neurological [1,3], ocular [4] manifestations, and even sudden sensorineural hearing loss [5]. More recently, the involvement of the joints has also been shown to be part of the spectrum, with patients presenting with acute arthritis [6], postinfectious/reactive arthritis [7], and viral arthralgia [8].…”

May polyenthesitis follow COVID-19?

“…Prevalence of myalgia, arthralgia and fatigue is high in coronavirus disease 2019 (COVID-19) patients [1] , [2] and current literature outlines the possibility of viral [3] or reactive [4] , [5] , [6] arthritis in individuals exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, in our experience, the spectrum of post-COVID-19 manifestations potentially referable to the heterogeneous family of spondyloarthritides may be even broader and also include predominant entheseal involvement.…”