Can serum interleukin-2 receptor alpha predict lymph node metastasis in early gastric cancer?

Baik, Yong-Hae; An, Ji Yeong; Noh, Jae Hyung; Sohn, Tae-Sung; Kim, Sung

doi:10.4174/jkss.2012.82.3.143

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…It has been demonstrated that the CXCL-16/CXCR6 axis promotes hepatocellular carcinoma invasiveness and induces a proinflammatory tumor environment for metastasis in various cancer types (Gao et al 2012 ; Richardsen et al 2015 ). The level of IL-2Rα in the serum of early gastric cancer patients may be a good predictor for lymph node metastasis (Baik et al 2012 ; He et al 2017 ). MMP-9 is one of the most important MMPs involved in tumor invasion and metastasis (Si et al 2018 ), whereas MMP-1 has also been reported to activate endothelial PAR-1 to facilitate endothelial permeability and transendothelial migration of tumor cells, and thus to promote metastatic dissemination (Andrae et al 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of VEGFR1+ hematopoietic progenitor cells on pre-metastatic niche formation and in vivo metastasis of breast cancer cells

Meng

Luo

et al. 2018

J Cancer Res Clin Oncol

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The pre-metastatic niche has been shown to play a critical role in tumor metastasis, and its formation is closely related to the tumor microenvironment. However, the underlying molecular mechanisms remain unclear. In the present study, we successfully established a mouse model of lung metastasis using luciferase-expressing MDA-MB-435s cells. In this model, recruitment of vascular endothelial growth factor receptor-1 (VEGFR1) + CD133 + hematopoietic progenitor cells (HPCs) was gradually increased in lung but gradually decreased after the formation of tumor colonies in lung. We also established a highly metastatic MDA-MB-435s (MDA-MB-435s-HM) cell line from the mouse model. Changes in protein profiles in different culture conditions were investigated by protein microarray analysis. The levels of CXC chemokine ligand 16, interleukin (IL)-2Rα, IL-2Rγ, matrix metalloproteinase (MMP)-1, MMP-9, platelet-derived growth factor receptor (PDGFR)-α, stromal cell-derived factor (SDF)-1α, transforming growth factor (TGF)-β, platelet endothelial cell adhesion molecule (PECAM)-1 and vascular endothelial (VE)-cadherin were significantly greater (> fivefold) in the culture medium from MDA-MB-435s-HM cells than in that from MDA-MB-435s cells. Moreover, the levels of MMP-9, PDGFR-α, and PECAM-1 were significantly greater in the co-culture medium of MDA-MB-435s-HM cells and CD133 + HPCs than in that from MDA-MB-435s-HM cells. Differentially expressed proteins were validated by enzyme-linked immunosorbent assay, and expression of their transcripts was confirmed by quantitative real-time polymerase chain reaction. Moreover, inhibition of MMP-9, PDGFR-α, and PECAM-1 by their specific inhibitors or antibodies significantly decreased cell migration, delayed lung metastasis, and decreased recruitment of VEGFR1 + CD133 + HPCs into lung. Intra-hepatic growth of HPCs enhanced the invasive growth of MDA-MB-435s-HM cells in the liver. Our data indicate that VEGFR1 + CD133 + HPCs contribute to lung metastasis. Electronic supplementary material The online version of this article (10.1007/s00432-018-2802-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effects of VEGFR1+ hematopoietic progenitor cells on pre-metastatic niche formation and in vivo metastasis of breast cancer cells

Meng

Luo

et al. 2018

J Cancer Res Clin Oncol

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“… 7 Endoscopic ultrasonography is another important modality for predicting LNM. Nevertheless, the predictive accuracy is only 55–75% 26 because it is deeply influenced by the size of the lymph node. Genetic or protein markers for predicting LNM in EGC patients are being gradually recognized.…”

Section: Discussionmentioning

confidence: 99%

Loss of OLFM4 promotes tumor migration through inducing interleukin-8 expression and predicts lymph node metastasis in early gastric cancer

et al. 2016

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Endoscopic surgery is increasingly used for early gastric cancer (EGC) treatment worldwide, and lymph node metastasis remains the most important risk factor for endoscopic surgery in EGC patients. Olfactomedin 4 (OLFM4) is mainly expressed in the digestive system and upregulated in several types of tumors. However, the role of OLFM4 in EGC has not been explored. We evaluated OLFM4 expression by immunohistochemical staining in 105 patients with EGC who underwent gastrectomy. The clinicopathological factors and OLFM4 expression were co-analyzed to predict lymph node metastasis in EGC. The metastatic mechanism of OLFM4 in gastric cancer was also investigated. We found that OLFM4 was upregulated in EGC tumor sections, and relatively low expression of OLFM4 was observed in patients with lymph node metastasis. OLFM4 expression as well as tumor size and differentiation were identified as independent factors, which could be co-analyzed to generate a better model for predicting lymph node metastasis in EGC patients. In vitro studies revealed that knockdown of OLFM4 promoted the migration of gastric cancer cells through activating the NF-κB/interleukin-8 axis. Negative correlation between OLFM4 and interleukin-8 expression was also observed in EGC tumor samples. Our study implies that OLFM4 expression is a potential predictor of lymph node metastasis in EGC, and combing OLFM4 with tumor size and differentiation could better stratify EGC patients with different risks of lymph node metastasis.

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Lymph node metastasis in early gastric cancer

Rong,

Qingsheng,

Jianxin

et al. 2014

Chinese Medical Journal

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Objective To discuss the clinicopathological factors for lymph node metastasis (LNM) in early gastric cancer (EGC), including age, gender, location, size, macroscopic type, depth of invasion, histological type, and lymphatic invasion, and the regulation of LNM in EGC. Data sources The data used in this review were mainly from PubMed articles published in English. The search terms were “early gastric cancer” and “lymph node metastasis.” Study selection Articles were selected if they reported the clinicopathological factors and regulation of LNM in EGC. Results The prognosis of EGC is better than advanced gastric cancer, with over 90% 5-year survival rate. The main risk factors for LNM in EGC are tumor size, macroscopic type, depth of invasion, histological type, ulceration, and lymphatic invasion. Conclusions LNM in EGC is a critical factor for assessment of prognosis and determination of therapeutic strategy. Endoscopic mucosal resection or endoscopic submucosal dissection should be considered when patients have low risk of LNM.

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Can serum interleukin-2 receptor alpha predict lymph node metastasis in early gastric cancer?

Cited by 3 publications

References 17 publications

Effects of VEGFR1+ hematopoietic progenitor cells on pre-metastatic niche formation and in vivo metastasis of breast cancer cells

Effects of VEGFR1+ hematopoietic progenitor cells on pre-metastatic niche formation and in vivo metastasis of breast cancer cells

Loss of OLFM4 promotes tumor migration through inducing interleukin-8 expression and predicts lymph node metastasis in early gastric cancer

Lymph node metastasis in early gastric cancer

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