Can Skin Be a Marker for Internal Malignancy? Evidence from Clinical Cases

Abstract

SUMMARY Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Analysis revealed paraneoplastic dermatoses in 17 patients with various skin lesions, i.e. eczematous dermatitis, vasculitis, subacute cutaneous lupus erythematosus, pruritus, chronic urticaria/angioedema, alopecia areata, flushing, bullous pemphigoid, dermatomyositis, and localized scleroderma (morphea). They were associated with different solid and hematologic malignancies (3 gastric, 2 prostate, 2 bladder, 2 thyroid, and 2 lymphoma), along with 1 case each of the following: lung, hepatocellular, esophageal, endometrial, kidney, and multiple myeloma. The majority of skin lesions gradually regressed after malignancy treatment. To our knowledge, our three cases of paraneoplastic eczematous dermatitis are the first to be associated with gastric, prostate and endometrial cancer. Additionally, we report a case of a patient with alopecia areata of the beard associated with thyroid cancer. Early malignancy detection based on skin markers makes early introduction of surgical/oncologic therapy possible and usually leads to skin lesion regression while reducing revolving door visits to specialists and the (financial) burden on the healthcare system.

Sister Mary Joseph Nodule, Umbilical Sentinel for an Endometrioid Endometrial Carcinoma in Postmenopause-Challenges for a Multidisciplinary Approach

“…The Jewish report is similar to a previous French study (1996) [26] describing 27 cases of SMJN secondary to endometrial carcinoma. After Piura B records (2006) [25], the incidence of endometrial carcinoma signaled by SMJN increased with a low number, as one registered in chronologic order: one endometroid endometrial carcinoma in a Canadian 62 years women (2007) [27]; one endometrial adenocarcinoma in UK (2009) [28];one case in USA (2012) in a 61 years old Afro-American women, SMJN being associated to endometrial poorly differentiated papillary carcinoma, extended to cervix) [29]; one case in Japan (2012) (endometrial squamous cell carcinoma in a 30 years women (2012) [30]; one case in Ireland (2019) [6]; one case in China (2019) (SMJN appeared in a 75 years old women, as a recurrence at 2 years from an endometrial carcinoma, not surgically removed, and treated only by chemotherapy (after 3 cures the sizes of SMJN were reduced, chemotherapy being continued when paper was published [31]; one case in Croatia, mentioned between other malignancies signaled by SMJN (2021) [32]. The authors considered the Romanian endometrioid endometrial carcinoma case, registered in 2018/2019 to be the 36th case of SMJN in the literature of different languages.…”

Psychosomatic aspects of renal pathology (literature review)

“…Актуальною проблемою в сучасній медичній практиці, у вирішенні якої психосоматичний підхід є провідним, вважаються розлади вегетативної регуляції. Проведений аналіз джерел наукової літератури з даного напряму пошуку вказав на широку зацікавленість як загальними питаннями психосоматичної медицини, так і причинами формування, проявами, діагностикою, лікуванням і можливими наслідками психосоматичних розладів при патології серцево-судинної системи [32][33][34][35], шлунково-кишкового тракту [36-38], органів дихання [39-41], залоз внутрішньої та зовнішньої секреції [42][43][44][45][46]. У той же час наукових досліджень щодо психосоматичних аспектів у нефрологічній практиці та дотичних фахових напрямах суттєво менше [47][48][49][50][51].…”