Can strain rate and strain quantify changes in regional systolic function during dobutamine infusion, B-blockade, and atrial pacing—implications for quantitative stress echocardiography

Effects of anesthesia on conventional and speckle tracking echocardiographic parameters in a mouse model of pressure overload

“…However, a previous study by Weidemann et al (19) indicated that strain increased following a reduction in HR. This contradiction may be explained by the following mechanism: Strain is determined primarily by ejection performance parameters Table V.…”

Defining the Transmurality of a Chronic Myocardial Infarction by Ultrasonic Strain-Rate Imaging

“…20 This study showed that either resting SR SYS or ⑀ SYS values can clearly differentiate nontransmural from transmural infarction. However, to distinguish between the differing ischemic substrates, 4,8,20 the use of only 1 deformation parameter is insufficient. To do this, it is necessary to measure SR SYS , ⑀ SYS , and PSI both at rest and during a graded dobutamine infusion (Table 2).…”

“…4,8,[17][18][19] Motion-based techniques, such as Doppler myocardial velocity measurement 17 or endocardial border detection by color kinesis, 18 are influenced by tethering effects and thus may not represent regional function. In contrast, ultrasonic strain-rate imaging provides several advantages for the quantification of rest or stress-induced ischemia: (1) it quantifies regional myocardial deformation at high temporal resolution; (2) it can quantify regional longitudinal deformation for all left and right ventricular segments; (3) changes in SR SYS have been shown to parallel changes in global contractility 20,21 and to be relatively heart rate independent 20 ; and (4) ⑀ SYS is related to global ejection performance as assessed by either stroke volume 22 or ejection fraction. 20 This study showed that either resting SR SYS or ⑀ SYS values can clearly differentiate nontransmural from transmural infarction.…”

“…In contrast, ultrasonic strain-rate imaging provides several advantages for the quantification of rest or stress-induced ischemia: (1) it quantifies regional myocardial deformation at high temporal resolution; (2) it can quantify regional longitudinal deformation for all left and right ventricular segments; (3) changes in SR SYS have been shown to parallel changes in global contractility 20,21 and to be relatively heart rate independent 20 ; and (4) ⑀ SYS is related to global ejection performance as assessed by either stroke volume 22 or ejection fraction. 20 This study showed that either resting SR SYS or ⑀ SYS values can clearly differentiate nontransmural from transmural infarction. However, to distinguish between the differing ischemic substrates, 4,8,20 the use of only 1 deformation parameter is insufficient.…”

Impaired global and segmental myocardial deformation assessed by two-dimensional speckle tracking echocardiography in patients with vitamin B12 deficiency

“…Subclinical changes in LV function in anemia can be identified by quantifying myocardial strain, a dimensionless measurement of deformation, expressed as a fractional or percentile change from an object's original dimension [9]. 2D STE has been shown to provide complementary information about the clinical assessment of cardiac function [10,11]. It may assess myocardial function and detect early subclinical myocardial involvement in many heart diseases, as well as quantify regional myocardial function in ischemic heart disease.…”