Can T2 predict who will develop ROA? Data from the OAI

Abstract

Results: MRI and clinical data were obtained in 95 patients. The typical patient participating in this study was a 65-year old woman with a body mass index (BMI) of 32 kg/m 2. The bivariate association between KOOS pain and each of the DCE-MRI perfusion variables showed statistically significant correlations: S IRE x (N-plateau þ N-washout) ("Inflammation") (r ¼ À0.42, p < 0.0001), S ME x (N-plateauþN-washout) (r ¼-0.43, p < 0.0001), N-plateau þ N-washout (r ¼ À0.43, p < 0.0001), volume of the IPFP (r ¼-0.39, p ¼ 0.0001), and "Inflammation" divided by the volume of the IPFP (r ¼ À0.37, p ¼ 0.0002). A statistically significant correlation was also seen between KOOS pain and MOAKS Hoffa-synovitis (r ¼ À0.21, p ¼ 0.046). Conclusions: Perfusion variables on DCE-MRI reflecting inflammation in the IPFP and MOAKS Hoffa-synovitis were associated with knee pain in obese KOA patients. These results suggest that severe inflammation in the IPFP is associated with severe pain in KOA and that DCE-MRI is a robust and promising method to study the impact of inflammation in KOA.