Can the Use of Specific Isomers Improve the Safety and Efficacy of Nonsteroidal Antiinflammatory Drugs?

White, Paul F.

doi:10.1213/01.ane.0000073350.96933.a1

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…For example, the clinical effect of S-( ‡)-ibuprofen at half the dose of the racemate was found to be more potent than, or at least equivalent to, the racemate in terms of relief from dental pain (Evans 2001). S-( ‡)ibuprofen was also reported to produce less gastric damage and exhibit improved analgesic and anti-inflammatory effects in rodents after intravenous and oral administration of S-( ‡)-ibuprofen (Bonabello et al 2003;White 2003).…”

Section: Parametermentioning

confidence: 99%

Pharmacokinetic interaction of ibuprofen enantiomers in rabbits

Lin

Hayakawa

Yanaguimoto

et al. 2004

Journal of Pharmacy and Pharmacology

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The potential interaction between two ibuprofen enantiomers was studied after intravenous administration of R-(-)-, S-(+)- and racemic ibuprofen to rabbits. The total body clearance values calculated by compartmental model analysis (0.65 +/- 0.21 for R-(-)-ibuprofen and 0.63 +/- 0.34 for S-(+)-ibuprofen) after intravenous administration of the racemate of ibuprofen were significantly smaller than those of individual enantiomers (0.95 +/- 0.23 for R-(-)-ibuprofen and 1.03 +/- 0.23 for S-(+)-ibuprofen), indicating that the enantiomer-enantiomer interaction results in a mutual inhibition. The enantiomeric interaction in the pharmacokinetic behaviour of ibuprofen after racemic administration is considered to be a result of an alteration in the metabolic or excretion phase (or both) rather than stereoselective protein binding in the systemic distribution.

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Section: Parametermentioning

confidence: 99%

Pharmacokinetic interaction of ibuprofen enantiomers in rabbits

Lin

Hayakawa

Yanaguimoto

et al. 2004

Journal of Pharmacy and Pharmacology

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“…Several studies have shown that intraoperative infusion of beta blockers, and particularly the β1-blocker, esmolol, decreases the intra- and post-operative use of opioids (Johansen et al, 1998; White et al, 2003; Chia et al, 2004; Collard et al, 2007). Moreover, beta blockers have synergistic effects with COX-2 inhibitors, preserving the immune function after surgery, and reducing the risk of postoperative metastasis in rats (Benish et al, 2008).…”

Section: Alternative Analgesic Interventionsmentioning

confidence: 99%

Morphine Use in Cancer Surgery

2011

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Morphine is the core of perioperative pain management. However, when it comes to cancer surgery the possibility that this drug might affect tumor recurrence and metastasis has raised concerns. The results of two recent retrospective clinical trials indicated that regional anesthesia/analgesia might be beneficial in prostate and breast cancer surgery. It was proposed that morphine could be responsible for the higher recurrence and mortality rate observed in the general anesthesia/opioid analgesia groups. Nevertheless, the results of several other retrospective studies and one randomized prospective trial failed to confirm any advantage for regional anesthesia/analgesia over general anesthesia and opioid analgesia. Moreover laboratory data on the effect of morphine on cancer are contradictory, ranging from tumor-promoting to anti-tumor effects. Considering that surgical stress and pain promote the recurrence and spread of cancer, choosing a proper analgesic strategy is of high significance. Although the question of whether morphine causes any harm to cancer patients remains unanswered, alternative analgesic regimens could be used concomitant to or instead of morphine to limit its potential adverse effects.

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Current awareness: Pharmacoepidemiology and drug safety

2003

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Can the Use of Specific Isomers Improve the Safety and Efficacy of Nonsteroidal Antiinflammatory Drugs?

Cited by 3 publications

References 17 publications

Pharmacokinetic interaction of ibuprofen enantiomers in rabbits

Pharmacokinetic interaction of ibuprofen enantiomers in rabbits

Morphine Use in Cancer Surgery

Current awareness: Pharmacoepidemiology and drug safety

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