Can visual inspection with acetic acid be used as an alternative to Pap smear in screening cervical cancer?

Saleh, Hend S

doi:10.1016/j.mefs.2013.10.003

Cited by 34 publications

(31 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IVA merupakan teknik yang bagus untuk skrining, sederhana, mudah, biaya murah dan mempunyai sensitifitas yang tinggi dibandingkan Pap smear, sehingga dapat digunakan sebagai teknik untuk skrining kanker serviks di daerah terpencil. 12 Hal tersebut dinyatakan berdasarkan hasil penlitian yang menunjukkan bahwa pemeriksaan IVA positif pada 24/200 orang (12%) dan hasil Pap smear abnormal 8(4%), 5 LSIL, 2 HSIL, 1 suspek ganas. Pap smear mempunyai sensitifitas 50,1%, spesifisitas 93,1%, nilai prediksi positif 89,3% dan nilai prediksi negatif 65,6%, sedangkan IVA mempunyai sensitifitas 90%, spesifisitas 37%, nilai prediksi positif 52% dan nilai prediksi negatif 81%.…”

Section: Bahan Dan Metodeunclassified

“…Pap smear mempunyai sensitifitas 50,1%, spesifisitas 93,1%, nilai prediksi positif 89,3% dan nilai prediksi negatif 65,6%, sedangkan IVA mempunyai sensitifitas 90%, spesifisitas 37%, nilai prediksi positif 52% dan nilai prediksi negatif 81%. 12 Teknik visualisasi langsung pada serviks dengan menggunakan asam asetat digunakan sebagai alternatif pengganti Pap smear pada negara sedang berkembang. Inspeksi visual dengan asam asetat 5% diaplikasikan pada serviks dengan cotton swab besar dan ditunggu 30-60 detik setelah pengolesan asam asetat hasil dapat dilihat.…”

Section: Bahan Dan Metodeunclassified

See 1 more Smart Citation

Skrining Kanker Serviks dengan Pemeriksaan Pap Smear di Puskesmas Tanah Kali Kedinding Surabaya dan Rumah Sakit Mawadah Mojokerto

Mastutik

Alia

Rahniayu

et al. 2015

MOG

View full text Add to dashboard Cite

Tujuan: Penelitian ini bertujuan untuk mengetahui prevalensi lesi prekanker serviks dengan cara melakukan skrining kanker serviks menggunakan pemeriksaan Pap smear.Bahan dan Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan metode pendekatan cross sectional yang dilakukan pada 140 wanita, terdiri dari 90 orang dari Puskes-mas Tanah Kali Kedinding Surabaya, dan 50 orang dari Rumah Sakit Mawadah Mojokerto, dengan usia 20-70 tahun. Pemeriksaan spesimen sitologi serviks dengan pengecatan Papaniculaou dan klasifikasi hasil pemeriksaaan sitologi berdasar-kan klasifikasi Papaniculaou dan sistim Bethesda. Pemeriksaan inspeksi visual asam asetat (IVA) adalah metode lain untuk skrining kanker serviks dilakukan dengan mengoleskan asam asetat 5% pada area serviks dan melakukan pengamatan satu menit kemudian.Hasil: Hasil pemeriksaaan Pap smear menunjukkan Papaniculaou kelas I (sama dengan normal pada klasifikasi sistim Bethesda) yaitu 12.1%, kelas II (sama dengan NILM pada klasifikasi sistim Bethesda) yaitu 86, 4%, dan kelas III (sama dengan LSIL pada klasifikasi sistim Bethesda) yaitu 1,4%. Hasil pemeriksaan IVA menunjukkan 6,43% positif dan 93,57% negatif. Hasil pemeriksa-an IVA positif terdapat pada 9/140 orang yang merupakan proses keradangan dan infeksi, bukan merupakan lesi prekanker.Simpulan: Prevalensi lesi prekanker yaitu 1,4%. Pemeriksaan IVA menunjukkan hasil positif semu yang disebabkan oleh proses radang atau infeksi pada serviks.

show abstract

Section: Bahan Dan Metodeunclassified

Skrining Kanker Serviks dengan Pemeriksaan Pap Smear di Puskesmas Tanah Kali Kedinding Surabaya dan Rumah Sakit Mawadah Mojokerto

Mastutik

Alia

Rahniayu

et al. 2015

MOG

View full text Add to dashboard Cite

show abstract

“…[11] While Cronjé et al 2003 [12] reported a higher prevalence of LSIL and above smears, Luthra et al [9] found lower prevalence (dysplasias 1.4% and carcinoma 0.15%). In contrary Ghosh et al, 2013, [13] reported abnormal Pap smear in 3.7% cases only while Saleh et al 2013, [14] in an Egyptian study, as 4%. The present study used two thresholds of VIA to determine whether the specificity of the test can be further increased without any loss of sensitivity.…”

Section: Discussionmentioning

confidence: 87%

Potential of visual inspection with acetic acid as a screening test in comparison to conventional papanicolaou smear in detection of colposcopic biopsy proven cervical intraepithelial neoplasia: A tertiary centre experience

Bajaj¹,

Ahmad²,

Trivedi³

2017

Int J Med Sci Public Health

View full text Add to dashboard Cite

INTRODUCTIONAs per population-based cancer registries in India, cervical carcinoma is the second most common cancer among women after breast cancer.[1] Majority (83%) of the cases occur in developing countries which possess only 5% of global resources.[2] India is a high-risk country for cervical cancer, Background:Although it is well established that organized cytological screening programs are the mainstay for cancer cervix control but the financial and logistic burden of operating such a program is considerable. This has prompted the evaluation of alternative feasible techniques. Early and ongoing comparative studies worldwide showed visual inspection with acetic acid (VIA) as potential alternatives to cervical cytology because of their low cost, the ease of use, high sensitivity and immediate result allowing "see and treat" at first visit. Objectives: To evaluate the performance of VIA and its comparison with cytology in cervical cancer screening. Materials and Methods: A total of 400 non-pregnant reproductive age women were subjected to papanicolaou Pap smear) and VIA in this prospective study done in a tertiary-care centre in Delhi. Reference standard used for all was colposcopy and colposcopic-directed biopsy (when required). Results: Of 400 Pap smears done 11.75% were normal, 77.5% inflammatory, 5.5% had atypical squamous cells (ASC) atypical glandular cells of undetermined significance (AGUS), 0.25% ASC-H, 0.5% AGUS, 2% low-grade squamous intraepithelial lesions (LSIL), 1.5% high-grade squamous intraepithelial lesion (HSIL), and invasive cancer in 0.5%. With LSIL and above smears as significant, the sensitivity and specificity of Pap were 50% and 97.66%, respectively. VIA was positive according to two thresholds. When high-threshold was used then only well demarcated, opaque white areas near the squamocolumnar junction were taken as positive whereas in low-threshold criterion faint or ill-defined ace to white anywhere and well-defined areas away from squamocolumnar junction was also taken as positive. 29.3% were positive with low-threshold criterion for VIA and 9.3% with high-threshold criterion. The sensitivity with low-threshold criteria was 100% and specificity 72.7%. Conclusion: The sensitivity with low-threshold criteria was 100% and specificity 72.7%. With high-threshold sensitivity and specificity were 85.7% and 95%, respectively. Conclusion: VIA with low-threshold criteria had high sensitivity (100%), but specificity (72.7%) was low, but with high-threshold criteria for positivity, the specificity increases up to 95% which is comparable to cytology. The gynecologists in tertiary-care centers can use the high-threshold criterion effectively, and patient with significant lesions can be directly subjected to further treatment at the earliest thus reducing loss to follow-up.

show abstract

“…In contrary Ghosh et al, reported abnormal pap smear in 3.7% cases only while Saleh et al in an Egyptian study, as 4%. 18,[21][22][23] VILI is the visualization of cervix after application of Lugol's iodine. It is considered positive if SCJ or entire cervix or growth turned yellow (non-uptake areas).…”

Section: Discussionmentioning

confidence: 99%

Comparison of diagnostic value of visual inspection with Lugol’s iodine to conventional Paps smear in detection of colposcopic biopsy proved CIN: a tertiary care experience

Bajaj

Ahmad

Trivedi

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: An organized cytological screening (Pap smear) is the mainstay for cervical cancer prevention and control programme. Financial and logistic burden of operating such a program is considerable. This has prompted the evaluation of alternative feasible techniques. It appeared from the earlier studies that visual inspection with lugol’s iodine (VILI) could be a potential alternative to cervical cytology. VILI is a low cost, easy to apply and highly sensitive technique. It gives result immediately thus allows doctors to “see and treat” at first visit. Objective of present study was to evaluate the performance of visual inspection with lugol’s iodine and its comparison with cytology in cervical cancer screening. Methods: 400 non-pregnant reproductive age women were subjected to Paps and VILI in this prospective study done in a tertiary-care centre in Delhi. Reference standard used for all was colposcopy and colposcopic-directed biopsy (when required).Results: Of 400 Pap smears done 11.75% were normal, 77.5% inflammatory, 5.5% had ASCUS, 0.25% ASC-H, 0.5% AGUS, 2% LSIL, 1.5% HSIL and invasive cancer in 0.5%. With LSIL and above smears as significant, the sensitivity and specificity of Paps were 50% and 97.66% respectively. VILI was positive in 12.8% of cases. Sensitivity and specificity of VILI was 85.5% and 89.9% respectively. Overall accuracy of VILI in detecting pre-invasive lesion was 89.7% while with pap smear it was 96%.Conclusions: Accuracy of VILI and Pap smear in detecting pre-invasive cervical lesion was comparable. At tertiary-care centers VILI can be used effectively to screen the patients with significant lesions. Patients can be directly subjected to further treatment at the earliest thus reducing loss to follow-up.

show abstract

Can visual inspection with acetic acid be used as an alternative to Pap smear in screening cervical cancer?

Cited by 34 publications

References 12 publications

Skrining Kanker Serviks dengan Pemeriksaan Pap Smear di Puskesmas Tanah Kali Kedinding Surabaya dan Rumah Sakit Mawadah Mojokerto

Skrining Kanker Serviks dengan Pemeriksaan Pap Smear di Puskesmas Tanah Kali Kedinding Surabaya dan Rumah Sakit Mawadah Mojokerto

Potential of visual inspection with acetic acid as a screening test in comparison to conventional papanicolaou smear in detection of colposcopic biopsy proven cervical intraepithelial neoplasia: A tertiary centre experience

Comparison of diagnostic value of visual inspection with Lugol’s iodine to conventional Paps smear in detection of colposcopic biopsy proved CIN: a tertiary care experience

Contact Info

Product

Resources

About