Can we consider silymarin as a treatment option for vitiligo? A double-blind controlled randomized clinical trial of phototherapy plus oral <i>Silybum marianum</i> product versus phototherapy alone

Jowkar, Farideh; Godarzi, Hamid; Parvizi, Mohammad Mahdi

doi:10.1080/09546634.2019.1595506

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…The facial type includes “Kalaf ,” “ Barash , ” “Namash ,” and “Badeshnam .” 29 “ Bahaq ,” “ Baras ,” and “ Khilan ” (moles) are also diseases of the skin that affect the entire body if they become chronic 30,31 …”

Section: Resultsmentioning

confidence: 99%

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Applications of Ma'aljobon, a natural remedy from traditional Persian medicine, in dermatology: A journey from past to modernity

Zare

Parvizi

Saki

et al. 2020

Dermatologic Therapy

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Ma'aljobon, a handmade substance, is the liquid portion of coagulated milk after adding vinegar to the heated milk. In traditional Persian medicine (TPM) it has been known as a useful remedy for the treatment of some skin disorders. The aim of this study was to review the applications of Ma'aljobon for skin diseases according to the sages of TPM and modern medicine. Main TPM sources were reviewed with the keyword of "Ma'aljobon." Furthermore, electronic databases including Scopus, PubMed, SID, and Google Scholar were searched with the keyword "Whey protein" during 2000 to 2018. According to TPM sources, Ma'aljobon was used by Iranian sages as a safe and effective remedy to treat a wide range of skin diseases, such as pimples, and ulcers. Meantime, recent evidence has also shown the effectiveness of whey protein in treating some skin disorders such as atopic dermatitis. Gastrointestinal discomfort was the most adverse effect of Ma'aljobon mentioned in TPM sources. In conclusion, there were several applications for Ma'aljobon in treatment of dermatologic disease according to TPM, as well as modern medicine. These finding could be the basis of future clinical trials on the effects of Ma'aljobon in the treatment of skin problems.

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Section: Resultsmentioning

confidence: 99%

“…29 "Bahaq," "Baras," and "Khilan" (moles) are also diseases of the skin that affect the entire body if they become chronic. 30,31 Kalaf is a skin condition similar to freckles and lentigo in which, roughness of skin does not exist. Barash and Namash are about the same.…”

Section: Such Asmentioning

confidence: 99%

Applications of Ma'aljobon, a natural remedy from traditional Persian medicine, in dermatology: A journey from past to modernity

Zare

Parvizi

Saki

et al. 2020

Dermatologic Therapy

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“…Most of patients referring to TPM clinics were suffering from chronic diseases, which had not received appropriate treatment from modern medicine (16). The literature revealed that the most patients who referred to TPM clinics had selected traditional treatment as the end step of their therapeutic process and they hope that they would have had an acceptable therapeutic response to improve the quality of life (17,18).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Factors in Patients with Dermatologic Conditions Referring to Clinic of Traditional Persian Medicine, Shiraz, Southern Iran during 2018: A Cross- Sectional Study

Parvizi

Fatehi

Jaladat

et al. 2021

Preprint

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Introduction: Many patients with chronic diseases often use the traditional medicine approach in addition to conventional medicine. The aim of this study was to evaluate the epidemiological factors of patients with dermatologcal conditions referring to traditional Persian Medicine (TPM) clinic. Materials and Methods: In this cross-sectional study, we reviewed all the patients’ medical documents with dermatological conditions referred to the TPM clinic at Shiraz, Southern Iran in 2018. Then, the epidemiological factors of the patients were recorded to a researcher-made data collection form. SPSS software version 22 was conducted to data analysis. Results: Overall, 631 patients consist of 151 (23.9%) male individuals and 580 (76.1%) female individuals were enrolled to the study. Most of the patients were aged between 31 and 40 years, and 347 (55%) patients were married, and most of them were housewives. The frequency of patients in spring was higher than other seasons. Furthermore, the most of the patients were university educated. Acne, eczema and hair loss were the three most complaints of the patients referring to the traditional medicine clinic. 301(47.7%) patients reported gastrointestinal problems as another complaint concomitant with their skin problems. Conclusion: It seems that women with skin problems, including acne, eczema, and hair loss, were more likely to refer to the TPM clinic. Therefore, development of TPM clinics in dermatology field as a scientific and academic approach can be effective in the treatment of patients with dermatological condition accompanied by traditional medicine.

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“…They observed significant improvement in repigmentation in patients treated with both antioxidant therapy plus NB-UVB and NB-UVB alone. However, a better response was seen in the first group [58]. − ] 2 which mimics the effect of catalase.…”

Section: Oral Antioxidant Supplementationmentioning

confidence: 92%

“…It acts as a scavenger of free radicals and prevent peroxidation processes [107]. In fact, intake of silymarin extract was associated with a reduction in depigmented areas in vitiligo patients [58].…”

Section: Nutraceuticals As Antioxidantsmentioning

confidence: 99%

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.

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Can we consider silymarin as a treatment option for vitiligo? A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone

Cited by 15 publications

References 22 publications

Applications of Ma'aljobon, a natural remedy from traditional Persian medicine, in dermatology: A journey from past to modernity

Applications of Ma'aljobon, a natural remedy from traditional Persian medicine, in dermatology: A journey from past to modernity

Epidemiological Factors in Patients with Dermatologic Conditions Referring to Clinic of Traditional Persian Medicine, Shiraz, Southern Iran during 2018: A Cross- Sectional Study

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

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