Can We Make High-Density Lipoproteins Great Again?

Identification of Novel Compounds Enhancing SR-BI mRNA Stability through High-Throughput Screening

“…[1][2][3][6][7][8] The treatment of atherosclerotic diseases targeting HDL and its relevant receptor has received widespread attention. [1][2][3][6][7][8][9][10] Human scavenger receptor class B, member 1 (SR-BI or SCARB1), also known as CD36 and lysosomal integral membrane protein II analogous 1 (CLA-1) in humans, is an important integral membrane glycoprotein of the scavenger receptor family. [1][2][3]11 SR-BI is mainly expressed in the liver, gastrointestinal tract, and steroidogenic organs or is detected in macrophages and endothelial cells.…”

“…13,14 The key mechanism of HDL-C transport is the selective uptake of the cholesterol esters. [1][2][3][6][7][8][9][10] As a functional HDL receptor with high expression level in the liver, SR-BI binds with HDL to mediate the selective uptake of HDL-C with high affinity and high saturation, and this process is the final rate-limiting step of RCT. [1][2][3][4]6 The overexpression of hepatocyte SR-BI can indeed promote the reverse transport of HDL-C, enhance the HDL clearance rate in plasma, and reduce the morbidity and mortality of atherosclerosis and associated cardiovascular risk events.…”

“…[1][2][3][4]6 The overexpression of hepatocyte SR-BI can indeed promote the reverse transport of HDL-C, enhance the HDL clearance rate in plasma, and reduce the morbidity and mortality of atherosclerosis and associated cardiovascular risk events. [1][2][3][6][7][8][9][10] Given that SR-BI plays an important role in lipid metabolism and atherosclerosis pathogenesis, the development of new anti-atherosclerotic drugs for the treatment and prevention of cardiovascular disease using SR-BI as the target has aroused widespread attention. 3,7,9,11,15 The posttranscriptional level of gene regulation is one of the main features of regulation of eukaryotic gene expression.…”

“…1–3,6–8 The treatment of atherosclerotic diseases targeting HDL and its relevant receptor has received widespread attention. 1–3,6–10…”