Can we predict postinflammatory hyperpigmentation after laser treatment based on dermoscopic findings of solar lentigo?

Park, Jong Heon; Lee, Jong Hee; Chung, Bo Young; Kim, Jeong Eun; Shin, Jeong Hyun; Oh, Sang Ho; Choi, Mira; Lee, Si Hyung; Kim, You Chan; Ryu, Hwa Jung

doi:10.1007/s10103-023-03790-6

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…The diagnosis of SL is primarily determined by histopathology, which has been reported as two patterns-a flattened epidermis with basal melanosis and epidermal hyperplasia with elongated rete ridges [1]. Other noninvasive diagnostic methods for SL include dermoscopy (moth-eaten border, homogenous pigmentation, pigment network, pseudonetwork, erythema, and bluish-gray granules) [2], reflectance confocal microscopy (suprapapillary cobblestone pattern, polycystic papillary contours, bulbous projections, and crumbled coarse bright collagen) [3], and line-field confocal optical coherence tomography [4].…”

Section: Introductionmentioning

confidence: 99%

“…Disturbance in the neurohormonal mediators and cytokines regulating physiological skin functions results in cutaneous pigmentary disorders [14]. Histologically, inflammatory features such as infiltration of inflammatory cells and interface changes were found in SL [2]. Gene expression profiling showed increased expression of inflammation-related genes in SL [9].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported the association of "erythematous SL" or "inflammatory SL" with the infiltration of inflammatory cells and interface changes in histology and high susceptibility to post-inflammatory hyperpigmentation after laser treatment [2,19,20]. Morgan et al demonstrated that the inflammatory SL could be a clinicopathologic spectrum of lichen planus-like keratosis, representing the inflammatory stage of involuting SL [21].…”

Section: Introductionmentioning

confidence: 99%

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Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo

Jeong,

Lee,

Kim

et al. 2024

IJMS

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Although the pathogenesis of solar lentigo (SL) involves chronic ultraviolet (UV) exposure, cellular senescence, and upregulated melanogenesis, underlying molecular-level mechanisms associated with SL remain unclear. The aim of this study was to investigate the gene regulatory mechanisms intimately linked to inflammation in SL. Skin samples from patients with SL with or without histological inflammatory features were obtained. RNA-seq data from the samples were analyzed via multiple analysis approaches, including exploration of core inflammatory gene alterations, identifying functional pathways at both transcription and protein levels, comparison of inflammatory module (gene clusters) activation levels, and analyzing correlations between modules. These analyses disclosed specific core genes implicated in oxidative stress, especially the upregulation of nuclear factor kappa B in the inflammatory SLs, while genes associated with protective mechanisms, such as SLC6A9, were highly expressed in the non-inflammatory SLs. For inflammatory modules, Extracellular Immunity and Mitochondrial Innate Immunity were exclusively upregulated in the inflammatory SL. Analysis of protein–protein interactions revealed the significance of CXCR3 upregulation in the pathogenesis of inflammatory SL. In conclusion, the upregulation of stress response-associated genes and inflammatory pathways in response to UV-induced oxidative stress implies their involvement in the pathogenesis of inflammatory SL.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo

Jeong,

Lee,

Kim

et al. 2024

IJMS

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Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation

Wu,

Lv,

Han

et al. 2024

J of Cosmetic Dermatology

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Background and AimsSolar lentigo is a prevalent skin condition that affects a significant number of individuals. Fortunately, certain traditional Chinese medicines and monomers (TCMM) have proven effective in addressing these concerns. In this study, we evaluated the efficacy and underlying mechanism of TCMM, a combination of TCM and monomers in repairing solar lentigo.MethodsWe detected and identified the main compounds of TCM using liquid chromatography‐mass spectrometry (LC–MS) and through the approach of network pharmacology, we screened drug and disease targets, visualized networks with Cytoscape software, analyzed targets via Gene ontology and KEGG, clinically validated predictions. In a mouse model, UVB‐induced pigmentation was assessed, and the effects of TCMM were evaluated. A clinical trial on 30 patients validated the depigmenting agent.ResultsActive ingredients such as MSH, Butylated hydroxytoluen, Valerophenone, and Geranylacetone aid pigmentation treatment. One hundred and forty‐three crore targets impact PI3K‐Akt, MAPK signaling pathway, ect. pathways. TCMM reduced UVB‐induced pigmentation, water loss, epidermal thickness, and melanin. It inhibited TYR, MITF, AKT1, VEGFA, PTGS2, TNF‐α, IL‐6, IL‐1β. Clinical and microscopic analysis showed significant pigmentation reduction.ConclusionsThe treatment of solar lentigo can benefit from the TCMM. By targeting multiple factors and pathways, this approach offers a comprehensive and effective treatment strategy.

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Unstable solar lentigo mimicking lentigo maligna melanoma: A case report

Achar,

Hakim,

Dutta

et al. 2023

IJCED

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Solar lentigo (SL) is a hyperpigmented macule that develops due to chronic ultraviolet exposure. A 35-year-old housewife, presented with an asymptomatic pigmented patch on the right side of her nose for the last 10 years, with a rapid increase in size and variability in pigmentation over the last 3 years. She had no history of excessive sun exposure. Upon examination, there was a solitary, hyperpigmented, well to ill-defined patch of irregular shape and margin, measuring 3 cm * 2.5 cm, with variability in colour and areas of regression, almost covering Right side of nose. The patch appeared light brown with areas of dark brown and black. Differential diagnoses considered were Lentigo maligna melanoma (LMM), Solar Lentigo (SL), and flat seborrheic keratosis. Dermoscopy (Polarised illuco IDS-1100 dermoscope) revealed diffuse brown pigmentation with a faint pigmented network, along with dark brown to black globules and blotches. Due to the asymmetry of pigmentation, a punch biopsy was performed from the area of darkest pigmentation to rule out LMM. In Histology, the epidermis exhibited hyperkeratosis, follicular plugging, acanthosis, and downward elongation of the rete ridges. There was hyperpigmentation of the basal layer, an increased number of melanocytes, and the presence of melanophages in the papillary dermis. The biopsy report was consistent with Solar Lentigo (SL), and we concluded it as unstable solar lentigo (USL). This case is presented due to its clinical and dermoscopic resemblance to LMM and to increase awareness of USL and the importance of periodic surveillance.

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Can we predict postinflammatory hyperpigmentation after laser treatment based on dermoscopic findings of solar lentigo?

Cited by 3 publications

References 22 publications

Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo

Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo

Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation

Unstable solar lentigo mimicking lentigo maligna melanoma: A case report

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