Can we use postal surveys with anonymous testing to monitor chlamydia prevalence in young women in England? Pilot study incorporating randomised controlled trial of recruitment methods: Table 1

Woodhall, Sarah C; Nichols, Tom; Alexander, Sarah; Silva, Filomeno Coelho da; Mercer, Catherine H; Ison, Catherine; Gill, O N; Soldan, Kate

doi:10.1136/sextrans-2015-052067

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…Previous work has investigated the use of age-specific seroprevalence for surveillance in the peri- 16 and post-MDA setting 15 , 17 , 18 . Serological techniques for the detection of antibodies against Ct have been used to study the epidemiology of both urogenital and ocular Ct infections 19 , 20 . An enzyme-linked immunoassay (ELISA) which detects antibodies against Pgp3 (pCT03) has recently been used for analysis of samples collected from trachoma-endemic regions 21 , 22 .…”

Section: Introductionmentioning

confidence: 99%

Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia

Migchelsen

Sepúlveda

Martin

et al. 2017

Sci Rep

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Trachoma is caused by Chlamydia trachomatis (Ct). It is targeted for global elimination as a public health problem. In 2014, a population-based cross-sectional study was performed in two previously trachoma-endemic areas of The Gambia. Participants of all ages from Lower River Region (LRR) (N = 1028) and Upper River Region (URR) (N = 840) underwent examination for trachoma and had blood collected for detection of antibodies against the Ct antigen Pgp3, by ELISA. Overall, 30 (1.6%) individuals had active trachoma; the prevalence in children aged 1–9 years was 3.4% (25/742) with no statistically significant difference in prevalence between the regions. There was a significant difference in overall seroprevalence by region: 26.2% in LRR and 17.1% in URR (p < 0.0001). In children 1–9 years old, seroprevalence was 4.4% in LRR and 3.9% in URR. Reversible catalytic models using information on age-specific seroprevalence demonstrated a decrease in the transmission of Ct infection in both regions, possibly reflecting the impact of improved access to water, health and sanitation as well as mass drug administration campaigns. Serological testing for antibodies to Ct antigens is potentially useful for trachoma programmes, but consideration should be given to the co-endemicity of sexually transmitted Ct infections.

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Section: Introductionmentioning

confidence: 99%

Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia

Migchelsen

Sepúlveda

Martin

et al. 2017

Sci Rep

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“…Cost per returned consent form and cost per consent form agreeing to vaccination will be defined as the total unit cost of all consumables and incentive where relevant, divided by the number of consent forms returned or the number of consent forms returned that are agreeing to vaccination (following the method of Woodhall et al [51]).…”

Section: Methodsmentioning

confidence: 99%

A protocol for a cluster randomised feasibility study of an adolescent incentive intervention to increase uptake of HPV vaccination among girls

Forster

Cornelius

Rockliffe

et al. 2017

Pilot Feasibility Stud

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Background: Uptake of the human papillomavirus (HPV) vaccine in the UK is good, but there are pockets of the community who remain unprotected. Immunisation teams usually require written parental consent for a girl to receive the vaccine. Evidence suggests that uptake of the vaccine might be improved by promoting consent form return (if returned, forms are likely to grant consent). Incentivising girls to return consent forms is a promising approach to promoting consent form return. Before testing the efficacy of an incentive intervention in a randomised controlled trial (RCT), we must first establish whether the RCT is feasible. In this randomised feasibility study, we aim to establish the feasibility of conducting a cluster RCT of an adolescent incentive intervention to increase uptake of HPV vaccination. Methods: At least six schools will be randomised to either an incentive intervention arm or a standard invitation arm. Girls in standard invitation arm schools will receive the usual HPV vaccine programme invitation materials. Girls attending schools in the incentive intervention arm will receive the standard invitation and will also be told that they will receive an incentive if they return their consent form (regardless of whether consent is granted or denied). The incentive is being entered into a prize draw to win a retail voucher. Feasibility objectives include estimating the schools' and parents' willingness to participate in the study and be randomised; response rates to questionnaires; the extent of missing data; the girls' and parents' attitudes towards the incentive offered; school staff experiences of participating, fidelity to the trial procedures, data on any unintended consequences and the possible mechanisms of action, and proof-of-concept evidence of the effect of the intervention on consent form return rates and uptake of the vaccine. Analysis of feasibility outcomes will primarily be descriptive. Consent form return rates and uptake of the vaccine will be presented by trial arm without comparison. Discussion: Incentivising HPV vaccine consent form return may promote HPV vaccine uptake. This study will provide the evidence needed to establish whether testing this incentive intervention using a RCT design in the future is feasible. Trial registration: ISRCTN72136061

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“…Previous work has investigated the use of age-specific seroprevalence for surveillance in the peri- 14 and post-MDA setting 13 , 15 , 16 . Serological techniques for the detection of antibodies against Ct have been used to study the epidemiology of both urogenital and ocular Ct infections 17 , 18 . An enzyme-linked immunoassay (ELISA) which detects antibodies against Pgp3 (pCT03) has recently been used for analysis of samples collected from trachoma-endemic regions 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

“…Serological techniques for the detection of antibodies against Ct have been used to study the epidemiology of both urogenital and ocular infections 12,13 . Recently, an enzyme-linked immunoassay (ELISA) which detects antibodies against Pgp3 (pCT03)—a highly immunogenic Ct-specific protein encoded by the plasmid, which is highly conserved among Ct isolates 14 —has been used for analysis of samples collected from trachoma-endemic regions 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia

Migchelsen

Sepúlveda

Martin³

et al. 2017

Preprint

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Trachoma is caused by Chlamydia trachomatis (Ct). It is targeted for global elimination as a public health problem. In 2014, a population-based cross-sectional study was performed in two previously trachoma-endemic areas of The Gambia. Participants of all ages from Lower River Region (LRR) (N = 1028) and Upper River Region (URR) (N = 840) underwent examination for trachoma and had blood collected for detection of antibodies against the Ct antigen Pgp3, by ELISA. Overall, 30 (1.6%) individuals had active trachoma; the prevalence in children aged 1–9 years was 3.4% (25/742) with no statistically significant difference in prevalence between the regions. There was a significant difference in overall seroprevalence by region: 26.2% in LRR and 17.1% in URR (p<0.0001). In children 1-9 years old, seroprevalence was 4.4% in LRR and 3.9% in URR. Reversible catalytic models using information on age-specific seroprevalence demonstrated a decrease in the transmission of Ct infection in both regions, possibly reflecting the impact of improved access to water, health and sanitation as well as mass drug administration campaigns. Serological testing for antibodies to Ct antigens is potentially useful for trachoma programmes, but consideration should be given to the coendemicity of sexually transmitted Ct infections.

show abstract

Can we use postal surveys with anonymous testing to monitor chlamydia prevalence in young women in England? Pilot study incorporating randomised controlled trial of recruitment methods: Table 1

Abstract: (UKCRN ID 10913).

Cited by 8 publications

References 8 publications

Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia

Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia

A protocol for a cluster randomised feasibility study of an adolescent incentive intervention to increase uptake of HPV vaccination among girls

Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia

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