Cancer Anorexia-Cachexia Syndrome

Jackson, Markus; Abd‐Elsayed, Alaa

doi:10.1007/978-3-319-99124-5_210

Cited by 1 publication

(2 citation statements)

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“…Weight loss is associated with acutephase protein expression, such as elevated C-reactive protein and fibrinogen levels and decreased albumin levels [124]. Cancer cachexia syndrome is widespread in patients with cancer, and there is currently no specific effective treatment [125]. Studies on patients with cachexia pancreatic cancer have shown that protein synthesis during the acute phase increases during feeding as compared to fasting [124].…”

Section: Potential Caveats Of Implementing Fasting Strategies Cancer mentioning

confidence: 99%

“…However, another study showed that patients with fasting tumors have greater lipolysis than patients with stable weight [126]. A common dietary recommendation is to eat low-fat snacks regularly and take oral supplements [125,127]. It is also assumed that patients who are susceptible to or fasting on a fasting diet are prone to malnutrition, sarcopenia, and cachexia risk.…”

Section: Potential Caveats Of Implementing Fasting Strategies Cancer mentioning

confidence: 99%

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Fasting to enhance Cancer treatment in models: the next steps

2020

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Short-term fasting (STF) is a technique to reduce nutrient intake for a specific period. Since metabolism plays a pivotal role in tumor progression, it can be hypothesized that STF can improve the efficacy of chemotherapy. Recent studies have demonstrated the efficacy of STF in cell and animal tumor models. However, large-scale clinical trials must be conducted to verify the safety and effectiveness of these diets. In this review, we reexamine the concept of how metabolism affects pathophysiological pathways. Next, we provided a comprehensive discussion of the specific mechanisms of STF on tumor progression, derived through studies carried out with tumor models. There are currently at least four active clinical trials on fasting and cancer treatment. Based on these studies, we highlight the potential caveats of fasting in clinical applications, including the onset of metabolic syndrome and other metabolic complications during chemotherapy, with a particular focus on the regulation of the epithelial to mesenchymal pathway and cancer heterogeneity. We further discuss the advantages and disadvantages of the current state-of-art tumor models for assessing the impact of STF on cancer treatment. Finally, we explored upcoming fasting strategies that could complement existing chemotherapy and immunotherapy strategies to enable personalized medicine. Overall, these studies have the potential for breakthroughs in cancer management.

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Section: Potential Caveats Of Implementing Fasting Strategies Cancer mentioning

confidence: 99%

Section: Potential Caveats Of Implementing Fasting Strategies Cancer mentioning

confidence: 99%