Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

Ferlay, Jacques; Colombet, Murielle; Soerjomataram, Isabelle; Dyba, Tadeusz; Randi, Giorgia; Bettio, Manola; Gavin, Anna; Visser, Otto; Bray, Freddie

doi:10.1016/j.ejca.2018.07.005

Cited by 2,023 publications

(1,580 citation statements)

References 24 publications

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“…1,2 Additionally, in many European countries, the incidence of OSCC has been increasing. 1,2 Additionally, in many European countries, the incidence of OSCC has been increasing.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

et al. 2019

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Background MicroRNAs (miRNA) recently evolved as potential cancer biomarkers. Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). Method Expression levels of hsa‐mir‐21‐5p, hsa‐mir‐29b‐3p, hsa‐mir‐31‐5p, hsa‐mir‐99a‐5p, hsa‐mir‐99b‐3p, hsa‐mir‐100‐5p, hsa‐mir‐143‐3p and hsa‐mir‐155‐5p were analyzed in tumor tissue (n = 36) and healthy oral mucosal tissue (n = 17) and correlated with clinical variables. Results of the study cohort were validated in an OSCC cohort of The Cancer Genome Atlas. Results Increased hsa‐mir‐99b‐3p expression level showed a tendency toward advanced tumor stages, and high levels of hsa‐mir‐100‐5p expression were associated with extracapsular extension. While a high expression level of hsa‐mir‐99b‐3p was associated with better survival, a high expression level of hsa‐mir‐100‐5p was correlated with a poorer survival in the study cohort. Conclusion Our results indicate that hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p may serve as novel prognostic biomarkers in OSCC.

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“…1,2 Additionally, in many European countries, the incidence of OSCC has been increasing. 1,2 Additionally, in many European countries, the incidence of OSCC has been increasing.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

et al. 2019

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“…According to the European cancer statistics for 2018, the estimated number of new breast cancer cases is 522.500 and the estimated number of deaths is 137.700 [1]. Breast tumours are classified in four molecular subtypes, namely luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched and basal-like [2, 3].…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review

Kramer

Vangangelt

Pelt

et al. 2018

Breast Cancer Res Treat

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Purpose There is a strong need to improve the prognostication of breast cancer patients in order to prevent over- and undertreatment, especially when considering adjuvant chemotherapy. Tumour stroma characteristics might be valuable in predicting disease progression. Methods Studies regarding the prognostic value of tumour–stroma ratio (TSR) in breast cancer are evaluated. Results A high stromal content is related to a relatively poor prognosis. The most pronounced prognostic effect of this parameter seems to be observed in the triple-negative breast cancer (TNBC) subtype. Conclusions TSR assessment might represent a simple, fast and reproducible prognostic factor at no extra costs, and could possibly be incorporated into routine pathological diagnostics. Despite these advantages, a robust clinical validation of this parameter has yet to be established in prospective studies. Electronic supplementary material The online version of this article (10.1007/s10549-018-4987-4) contains supplementary material, which is available to authorized users.

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“…Colorectal cancer is a common malignancy with a poor mortality rate and a negative impact on the quality of life of survivors . The incidence rate of colorectal cancer is relatively high in the developed world and such figures are expected to continue rising in the future . Although the mortality rate of colorectal cancer has been declining as result of the ongoing developments in clinical practice, the average five‐year survival rate remains relatively poor at around 55% .…”

Section: Introductionmentioning

confidence: 99%

The expression of brown fat‐associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis

Alnabulsi

Cash

et al. 2019

Intl Journal of Cancer

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Colorectal carcinoma is one of the most common types of malignancy and a leading cause of cancer related death. The aberrant expression of a brown fat‐like phenotype in cancer cells has been previously implicated in tumour growth. Therefore, the expression of brown fat‐associated proteins in colorectal cancer could be associated with tumour prognosis. Monoclonal antibodies to brown fat‐associated proteins CIDEA, ELOVL3, ELOVL5, and UCP1 were developed. The antibodies were used to profile the expression of protein targets by immunohistochemistry in a discovery cohort comprising 50 normal colonic mucosa samples and 274 primary colorectal cancers and a validation cohort comprising 549 colorectal cancers. Immunostaining for UCP1 was observed in the majority of colorectal tumours while no immunostaining was observed in normal colonic mucosa (p < 0.001). The expression of UCP1 was significantly associated with better overall survival in both the discovery cohort (HR = 0.615, 95%CI = 0.416–0.909, χ2 = 6.119, p = 0.013) and the validation cohort (HR = 0.629, 95%CI = 0.480–0.825, χ2 = 11.558, p = 0.001). Furthermore, UCP1 was independently prognostic in multivariate analysis (p = 0.004). This study has identified the brown fat‐like phenotype as a novel pathway associated with survival in colorectal cancer. The expression of UCP1 was identified as a significant prognostic biomarker for colorectal cancer.

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Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

Cited by 2,023 publications

References 24 publications

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review

The expression of brown fat‐associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis

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