Cancer incidence in Martinique: a model of epidemiological transition

Dieye, Moustapha; Véronique-Baudin, Jacqueline; Draganescu, C.; Azaloux, H

doi:10.1097/01.cej.0000236246.78736.51

Cited by 19 publications

(19 citation statements)

References 18 publications

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“…Due to the nature of the Cuban medical system, it is unlikely that this is the result of the African population not having access to medical care. This finding is consistent with the low risk of developing thyroid cancer that has been observed in Martinique, where most of the population is of African origin [3]. This ratio of two is similar to that observed in the US Program of the Surveillance, Epidemiology and End Results (SEER) between populations of European and African origin [2].…”

Section: Discussionsupporting

confidence: 88%

“…Despite these limitations, it is now well established that the incidence of DTC is lower in people of African ethnicity origin than in others [2]. For example, in Martinique, a French Antilles island where most of the population is of African origin, the world age-standardized rate (ASR) of incidence was 0.8/100,000 men and 3.3/100,000 women during 1981-2000 [3]. These values are at least three times lower than those reported in metropolitan France [4].…”

Section: Introductionmentioning

confidence: 99%

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Environmental, Lifestyle, and Anthropometric Risk Factors for Differentiated Thyroid Cancer in Cuba: A Case-Control Study

et al. 2014

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Background: The incidence of differentiated thyroid carcinoma (DTC) is low in people of African origin and higher in populations living on islands, but there is no well-established explanation for these differences. Cuba is a multiethnic nation with people of African and Spanish descent. Until now, no study on the risk factors of DTC has focused on the Cuban population. Our aim is to establish the role of environmental and lifestyle factors and to relate anthropometric measurements to the risk of developing DTC in Cuba. Methods: We performed a case-control study of 203 DTC patients treated in two hospitals in Havana and 212 controls living in the area covered by these hospitals (i.e. parts of Havana and the municipality of Jaruco). Risk factors were analyzed using conditional logistic regression. Results: As has been shown by other studies, we found that non-African ethnicity, never smoking, parity, and high body mass index are risk factors significantly associated with DTC, whereas a history of exposure to ionizing radiation and level of education were not significantly related with disease development. Being rhesus factor-positive, having a personal history of benign thyroid disorder, agricultural occupation, and consumption of artesian well water were also associated with a significantly increased risk of developing DTC. Conclusions: The original findings reported here concern the risk of DTC that was associated with non-African ethnicity, positive rhesus factor, farming, and drinking water from an artesian well.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Environmental, Lifestyle, and Anthropometric Risk Factors for Differentiated Thyroid Cancer in Cuba: A Case-Control Study

et al. 2014

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“…The role of genetic factors, hormonal status and other environmental factors (dietary, infectious) should not be downplayed [22-24]. While aging, ethnicity and a family history of prostate cancer remain the only well-established risk factors for the disease, environment and lifestyle related factors are also suspected.…”

Section: Discussionmentioning

confidence: 99%

“…While aging, ethnicity and a family history of prostate cancer remain the only well-established risk factors for the disease, environment and lifestyle related factors are also suspected. On the island, changes in dietary habits and exposure to organochlorine pesticides are also etiological hypotheses, in addition to genetics and African ancestry [22,25]. …”

Section: Discussionmentioning

confidence: 99%

Geographic variations and temporal trends in prostate cancer in Martinique over a 25-year period

et al. 2014

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BackgroundIn Martinique, prostate cancer incidence rates have been increasing since the 1980s and are actually among the highest worldwide. Exposure to lifestyle (changes in dietary habits), environmental factors (exposure to organochlorine pesticides) and modifications in diagnostic and screening procedures, are favored etiological hypotheses. The aim of the present study is to describe and interpret prostate cancer incidence trends over the past 25 years (1981–2005) in Martinique.MethodsData on incident prostate cancer cases from 1981 to 2005 were obtained from the population-based Martinique Cancer Registry. World age-standardised incidence rates were calculated and an age-period-cohort model was used to determine average annual variations for prostate cancer during the study period. Age and period effects were assessed, employing the method proposed by Clayton and Schifflers. Relative changes in prostate cancer incidence, at five-year intervals between 1981 and 2005, were also studied with an organochlorine pesticide exposure index, built as a proxy of the relative intensity of chlordecone use on the island between 1973 and 1993.ResultsProstate cancer incidence was found to increase by 5.07% annually between 1981 and 2005. Compared to 1981–1985, prostate cancer relative risk, in men aged 50–74 years and 75 years and above was respectively 5.98% and 3.07% from 2001 to 2005. An inverse association between population pesticide exposure levels and prostate cancer risk was also highlighted, with highest prostate cancer incidences observed in urban zones showing the lowest soil contamination levels by the chlordecone pesticide (zone 1).ConclusionNo conclusive association was found between the intensity of pesticide use and the subsequent rise in prostate cancer incidence. However, it remains necessary to develop and reinforce continuous monitoring of prostate cancer incidence and mortality trends on the island. Further studies are also needed in order to consider other risk factors such as modifications in diagnostic and screening procedures over the last 25 years.

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“…Prostate cancer has become very frequent in Martinique and Guadeloupe and these two places are presently regarded as having one of the highest world age standardized incidence rates (9,10). Martinique and Guadeloupe are two tropical islands in the French West Indies.…”

Section: Introductionmentioning

confidence: 99%

Prostate cancer as an environmental disease: An ecological study in the French Caribbean islands, Martinique and Guadeloupe

Belpomme¹

2009

Int J Oncol

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Abstract. Using a transdisciplinary methodological approach we have conducted a multifactorial analysis in Martinique and Guadeloupe in order to elucidate the aetiology of prostate cancer. In 2002, world age standardized rates of prostate cancer were 152 new cases per 100,000 person-years in the two islands; one of the highest worldwide rates and much higher than those reported for other Caribbean islands and metropolitan France. Using a linear regression analysis, we found that the growth curves of incidence rates for Martinique and metropolitan France have been significantly diverging since 1983. That these curves are not parallel suggests that although a Caribbean genetic susceptibility factor may be involved in carcinogenesis, this factor cannot per se account for the observed growing incidence. On the basis of mapping analysis of soil pollution, we further showed that water contamination by pesticides originates from banana plantations. Moreover, we have established retrospectively that general population subjects investigated in 1972 in Martinique for the presence of organochlorinated pesticides in their adipose tissue had been contaminated by extremely high levels of DDT, DDE, ·, ß and ÁHCH, aldrin and dieldrin. Our study leads to the conclusion that the growing incidence of prostate cancer cannot be related either to a modification of ethnographic factors nor to a change in lifestyle and therefore suggests that environmental factors such as the intensive and prolonged exposure to carcinogenic, mutagenic and reproductive toxin pesticides may cause prostate cancer.

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Cancer incidence in Martinique: a model of epidemiological transition

Cited by 19 publications

References 18 publications

Environmental, Lifestyle, and Anthropometric Risk Factors for Differentiated Thyroid Cancer in Cuba: A Case-Control Study

Environmental, Lifestyle, and Anthropometric Risk Factors for Differentiated Thyroid Cancer in Cuba: A Case-Control Study

Geographic variations and temporal trends in prostate cancer in Martinique over a 25-year period

Prostate cancer as an environmental disease: An ecological study in the French Caribbean islands, Martinique and Guadeloupe

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