Cancer incidence in the AGRICAN cohort study (2005–2011)

Lemarchand, Clémentine; Tual, Séverine; Levêque-Morlais, Noémie; Perrier, Stéphanie; Belot, Aurélien; Velten, Michel; Guizard, Anne‐Valérie; Marcotullio, Elisabeth; Monnereau, Alain; Clin, Bénédicte; Baldi, Isabelle; Lebailly, Pierre

doi:10.1016/j.canep.2017.06.003

Cited by 60 publications

(55 citation statements)

References 40 publications

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“…Data from the Norwegian population indicated a significantly decreased standardised incidence ratio of 0.42 3. Two large agricultural cohorts confirmed these findings: the Agricultural Health Study (AHS) among pesticide applicators4 and the AGRIculture and CANcer (AGRICAN) cohort among French farmers 5. Two explanations were given for these results: (1) a lower prevalence of smoking in farmers compared with the general population, especially among farm owners6 and (2) exposure to livestock, which could be a protective factor,7–10 possibly in relation with endotoxins 11…”

Section: Introductionmentioning

confidence: 82%

Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort

et al. 2018

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Section: Introductionmentioning

confidence: 82%

Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort

et al. 2018

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“…Among studied pesticides, atrazine, imazethapyr, metolachlor, mancozeb, lindane, Agent Orange, MCPA, dinoseb, 2,4‐D, 2,4,5‐T, ioxynil, dichlorprop, DDT, fenitrothion, maneb, triadimefon, alachlor, pentachlorophenol, organochlorine insecticides, and organophosphate insecticides (malathion, diazinon, chlorpyrifos, and terbufos) were cited. Besides that, 6 studies verified phenoxy herbicides exposure and 11 studies did not define a specific type of pesticide . In addition, heterogeneity was present when the association between pesticide exposure and HNC was evaluated.…”

Section: Resultsmentioning

confidence: 99%

“…Among the 32 selected studies, 50% were conducted in European countries, 47% in North America, 9% in Oceania, and 6% in Asia . No studies were found in Latin America and Africa.…”

Section: Resultsmentioning

confidence: 99%

“…A great heterogeneity was found in relation to the pesticide and HNC site evaluated. The most observed HNC sites were oral cavity (78%), pharynx (50%), thyroid (50%), larynx (41%), lip (38%), nasal cavities (19%), paranasal sinuses (19%), and salivary glands (9%) . Most studies observed more than one site of HNC cancer.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the studies did not found evidence of an association between pesticides exposure and HNC . Only a few studies demonstrated that pesticide exposure would be associated with cancer in the oral cavity, pharynx, larynx, thyroid, nose, lip, and salivary glands …”

Section: Resultsmentioning

confidence: 99%

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Pesticides as risk factors for head and neck cancer: A review

Brasil

Pinto

Bonan

et al. 2018

J Oral Pathology Medicine

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Humans may be exposed to pesticides such as fungicides, herbicides, and insecticides, during occupational and non-occupational activities. Pesticides could be related to cancer development mainly because of their effects on the endocrine and immune systems and their cumulative effect. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of head and neck cancer (HNC). A literature search for cohort studies was conducted in the PubMed, Web of science, and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (SIGN) checklist. One thousand one hundred and thirty-two studies were identified. Thirty-two were included. Most of the studies found addressed occupational exposure to pesticides and were conducted in Europe and North America. Eleven high-quality studies were found. Most of them found no association between exposure to pesticides and increased risk of HNC. Two studies found some evidence of a positive association between pesticide (malathion and atrazine) exposure and thyroid cancer. The literature review does not support a clear evidence for association between pesticides exposure and HNC. Only limited evidence points to a positive association between exposure to some pesticides and thyroid cancer. Further standardized studies based on appropriate designs are required to clarify the effect of pesticides on the genesis of HNC, considering dose, length of exposure, and type of pesticide.

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Association of Occupational Pesticide Exposure With Immunochemotherapy Response and Survival Among Patients With Diffuse Large B-Cell Lymphoma

et al. 2019

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Cancer incidence in the AGRICAN cohort study (2005–2011)

Abstract: We found a decreased incidence for tobacco-related cancers and an increased incidence of prostate cancers, skin melanoma and multiple myeloma. Specific subgroups had a higher cancer incidence related to occupational status and pesticide use.

Cited by 60 publications

References 40 publications

Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort

Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort

Pesticides as risk factors for head and neck cancer: A review

Association of Occupational Pesticide Exposure With Immunochemotherapy Response and Survival Among Patients With Diffuse Large B-Cell Lymphoma

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