Cancer Metastasis

Zubair, Haseeb; Ahmad, Aamir

doi:10.1016/b978-0-12-804003-4.00001-3

Cited by 3 publications

(2 citation statements)

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“…Cancer, a major cause of death world-wide refers to the uncontrollable growth of cells that can metastasize. The localization of cancer at the primary site, is coupled with a good prognosis, however, metastasis, the term used to describe the escape of these cells from the primary site to other distant organs is difficult to treat ( Zubair and Ahmad, 2017 ; Smaranda, 2020 ) According to the WHO, approx. 10 million lives were lost in 2020 due to cancer, from which lung cancer accounted for 2.21 million cases ( WHO, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies

Soares

Bhattacharya²,

Mamledesai³

et al. 2022

Front. Pharmacol.

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12 analogs bearing a structural similarity to Linomide, a bonafide anticancer agent were synthesized wherein cyclization of substituted dianilides rendered 4-hydroxyquinolin-2(1H)-ones that were subjected to a Mannich reaction to yield 4-hydroxy-3-(substituted-1-ylmethyl) quinolin-2(1H)-one analogs. Characterization was performed using IR, 1H nuclear magnetic resonance and 13C NMR spectral analysis. Subsequently, in vitro anticancer studies revealed that Compound 4b showed maximum cytotoxicity with IC50 values of 1.539 μM/ml and 1.732 μM/ml against A549 and K562 cell lines respectively. This, however, is lower in comparison with standard Paclitaxel (IC50 values of 0.3 μM/ml for both cell lines). Surprisingly, docking studies at the active site of EGFRK revealed Compound 4b possessed a MolDock Score of -110.2253 that is highly comparable to the standard 4-anilinoquinazoline (MolDock Score of -112.04). Our computational and biological data thus provides an insight on the cytotoxicity of these derivatives and warrants future research that can possibly lead to the development of potent anticancer therapeutics.

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Section: Introductionmentioning

confidence: 99%

Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies

Soares

Bhattacharya²,

Mamledesai³

et al. 2022

Front. Pharmacol.

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“…As the primary cause of death for >90% of cancers, metastasis is the fourth and final stage of cancer during which cells gain the ability to leave their primary site, invade surrounding tissues, and disseminate to distant organs [ 1 ]. Research over the last two decades has been instrumental in revolutionizing our understanding of cancer progression and metastasis.…”

mentioning

confidence: 99%