Cancer Prevention by Phytochemicals

Nishino, Hoyoku; Murakoshi, Michiaki; Mou, Xiao; Wada, Saeri; Masuda, Michiaki; Ohsaka, Yasuhito; Satomi, Yoshiko; Jinno, Kenji

doi:10.1159/000086631

Cited by 68 publications

(47 citation statements)

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“…So, it is becoming increasingly important to screen natural products which might suppress or reverse the process of carcinogenesis [22]. The results of the current study, and many others, indicate several beneficial effects of rutin.…”

Section: Discussionsupporting

confidence: 56%

Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice

Dixit

2014

Medical Sciences

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Abstract:Rutin is the bioactive flavanoid isolated from the straw part of Triticum aestivum and possess various pharmacological applications. The aim of this study is to evaluate the chemopreventive potential of rutin in an experimental skin carcinogenesis mice model system. Skin tumor was induced by topical application of 7,12-dimethyl benz(a) anthracene (DMBA) and promoted by croton oil in Swiss albino mice. To assess the chemopreventive potential of rutin, it was orally administered at a concentration of (200 mg/kg and 400 mg/kg body weight) continued three times weekly for 16th weeks. The development of skin carcinogenesis was assessed by histopathological analysis. Reductions in tumor size and cumulative number of papillomas were seen due to rutin treatment. Average latent period was significantly increased as compared to carcinogen treated control. Rutin produced significant decrease in the activity of serum enzyme serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin when compared with the control. They significantly increased the levels of enzyme involved in oxidative stress glutathione (GSH), superoxide dismutase (SOD) and catalase. The elevated level of lipid peroxidase in the control group was significantly inhibited by rutin administration. The results from the present study suggest the chemopreventive effect of rutin in DMBA and croton oil induced skin carcinogenesis in swiss albino mice and one of the probable reasons would be its antioxidant potential.

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Section: Discussionsupporting

confidence: 56%

Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice

Dixit

2014

Medical Sciences

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“…These compounds, present in the regular diet, might be beneficial to human health by lowering the incidence of cancer and cardiovascular diseases [1,2]. They could also be employed in food processing as natural antioxidants in order to prevent lipid peroxidation, one of the main causes of food deterioration [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Antioxidants Identified by ESI-MS from Yerba Maté (Ilex paraguariensis) and Green Tea (Camelia sinensis) Extracts

et al. 2007

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Aqueous extracts of green yerba maté (Ilex paraguariensis) and green tea (Camellia sinensis) are good sources of phenolic antioxidants, as already described in the literature. The subject of this study were organic extracts from yerba maté, both green and roasted, and from green tea. Their phenolic profiles were characterized by direct infusion electrospray insertion mass spectrometry (ESI-MS) and their free radical scavenging activity was determined by the DPPH assay. Organic extracts containing phenolic antioxidants might be used as natural antioxidants by the food industry, replacing the synthetic phenolic additives used nowadays. Ethanolic and aqueous extracts from green yerba maté, roasted yerba maté and green tea showed excellent DPPH scavenging activity (>89%). The ether extracts from green and roasted yerba maté displayed a weak scavenging activity, different from the behavior observed for the green tea ether extract. The main phenolic compounds identified in green yerba maté water and ethanolic extracts were: caffeic acid, quinic acid, caffeoyl glucose, caffeoylquinic acid, feruloylquinic acid, dicaffeoylquinic acid and rutin. After the roasting process two new Molecules 2007, 12 424 compounds were formed: caffeoylshikimic acid and dicaffeoylshikimic acid. The ethanolic extracts from yerba maté, both roasted and green, with lower content of phenolic compounds (3.80 and 2.83 mg/mL) presented high antioxidant activity and even at very low phenolic concentrations, ether extract from GT (0.07 mg/mL) inhibited DPPH over 90%.

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“…Os alimentos oferecem diversas possibilidades de proteção ao organismo contra o desenvolvimento do câncer e outras doenças crônicas 2 ; entre os vários fatores que têm sido considerados responsáveis por essa proteção, podem ser citados os carotenóides, as vitaminas antioxidantes, os compostos fenólicos, os terpenóides, os esteróides, os indoles e as fibras 3,4 .…”

Section: N T R O D U ç ã Ounclassified

Carotenóides: uma possível proteção contra o desenvolvimento de câncer

Gomes

2007

Rev. Nutr.

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Este artigo discute as possibilidades de proteção contra o desenvolvimento do câncer, proporcionadas por carotenóides provenientes da alimentação, com base em uma revisão da literatura. Os carotenóides têm demonstrado uma ação protetora contra a carcinogênese, tanto em estudos in vitro como in vivo, com animais e humanos. Entre eles, a beta-criptoxantina, a fucoxantina, a astaxantina, a capsantina, a crocetina e o fitoeno, têm sido pouco explorados, e a literatura ainda se mostra extremamente limitada e pouco conclusiva. Estudos experimentais com humanos demonstraram não haver efeito, ou efeito reverso, do beta-caroteno, no entanto, não incluíram anteriormente variáveis intervenientes e interativas que deveriam ter sido controladas. A partir da evidência científica, baseada em estudos epidemiológicos e ensaios experimentais recentes, e da elucidação dos mecanismos de atuação de fitoquímicos relacionados à maior proteção contra o câncer, conclui-se que a alimentação rica em carotenóides provenientes das frutas, legumes e verduras, representa um possível fator de proteção contra o desenvolvimento do câncer.Termos de indexação: alimentação; carotenóides; frutas; neoplasias; quimioprevenção; vegetais. A B S T R A C T This study is a literature review that discusses the likelihood of dietary carotenoids offering protection against cancer. Carotenoids have been demonstrating a protective action against carcinogenesis both in vitro and

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Cancer Prevention by Phytochemicals

Cited by 68 publications

References 1 publication

Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice

Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice

Phenolic Antioxidants Identified by ESI-MS from Yerba Maté (Ilex paraguariensis) and Green Tea (Camelia sinensis) Extracts

Carotenóides: uma possível proteção contra o desenvolvimento de câncer

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