Cancer: Some genetic considerations

Salem, Marwa S.

doi:10.1016/j.ejmhg.2014.09.003

Cited by 4 publications

(2 citation statements)

References 16 publications

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“… 1 The high incidence rate of cancer may be due to several reasons, such as a mutation in genes, environmental factors, inadequate physical activity, different lifestyles, unstable eating-related behaviors, smoking, and alcohol consumption. 2 , 3 , 4 , 5 , 6 Present therapy options for treating different cancers at various stages of the disease are chemotherapy, radiation, and surgery for solid tumors or a combination of these. 7 Although these are effective in reducing the indicated cancer, they are associated with drawbacks and numerous side effects.…”

Section: Introductionmentioning

confidence: 99%

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

Ajumeera

Ajmeera

2024

Genes & Diseases

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Section: Introductionmentioning

confidence: 99%

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

Ajumeera

Ajmeera

2024

Genes & Diseases

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“…Cancer is a result of a continuous mutation in genes, which transform cellular functions. It generally disrupts the physiology of the cell and hamper the normal functioning of vital genes (Salem, 2015). The worldwide cancer burden is believed to be approximately around 18.1 million new cases and 9.6 million deaths in 2018 (International Agency for Research on Cancer [IARC], 2018).…”

Section: Introductionmentioning

confidence: 99%

Carotenoid isolates ofSpondias mombindemonstrate anticancer effects in DMBA‐induced breast cancer in Wistar rats through X‐linked inhibitor of apoptosis protein (XIAP) antagonism and anti‐inflammation

et al. 2020

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Breast cancer is the most prevalent cancer in women. X-linked inhibitor of apoptosis protein (XIAP) that is constantly overexpressed in cancer is a promising therapeutic target in cancer treatments. The mechanisms of the anticancer effects of carotenoid isolates of Spondias mombim in DMBA-induced breast cancer in Wistar rats through XIAP antagonism were investigated in the present study. Carotenoids isolated from the leaves of Spondias mombim were subjected to Liquid Chromatography/Mass Spectrometry (LC/MS) and Electrospray Ionization (ESI) for characterization. The characterized carotenoid isolates were docked against XIAP BIR2 domain and XIAP BIR3 domain. The anticancer effects of the carotenoid isolates of Spondias mombim in DMBA-induced breast cancer in Wistar rats were also investigated through the expression of XIAP, COX-2, TNF, BCl-2 mRNAs by qRT-PCR and biochemical parameters of catalase, lipid peroxidation, LDH, ALP, and ALT. These show the carotenoid isolates demonstrate anticancer effects by antagonism of XIAP, proapoptotic, and anti-inflammatory properties. Practical applications The present study showed that carotenoids (astaxanthin, β-carotene-15,15ʹ-epoxide, and 7,7ʹ,8,8ʹ-tetrahydro-β, β-carotene) isolated from the leaves of Spondias mombim are proapoptotic, it further gives credence to the chemopreventive abilities of carotenoids. This study validated XIAP as a druggable target in cancer treatment and hence more phytochemicals should be screened against it, for possible lead compounds of plant origin. Cancer cells often explore XIAP for antiapoptotic and resistance tendencies, hence, β-carotene-15,15ʹ-epoxide and 7,7ʹ,8,8ʹ-tetrahydro-β, β-carotene (XIAP antagonists) are promising drug candidates that can withstand resistant and prone cancer cells to apoptotic cell death. There is a need to synthesize β-carotene-15,15ʹepoxide and 7,7ʹ,8,8ʹ-tetrahydro-β for further investigation in clinical studies. K E Y W O R D S 7,12-dimethylbenz[a]anthracene (DMBA), baculovirus IAP repeat (BIR), breast cancer, liquid chromatography/mass spectrometry, X-linked inhibitor of apoptosis protein (XIAP) How to cite this article: Metibemu DS, Akinloye OA, Akamo AJ, et al. Carotenoid isolates of Spondias mombin demonstrate anticancer effects in DMBA-induced breast cancer in Wistar rats through X-linked inhibitor of apoptosis protein (XIAP) antagonism and anti-inflammation.

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Etiologic Role of Kinases in the Progression of Human Cancers and Its Targeting Strategies

Das

Bhattacharya

Das

et al. 2019

Indian J Surg Oncol

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Cancer: Some genetic considerations

Cited by 4 publications

References 16 publications

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

Carotenoid isolates ofSpondias mombindemonstrate anticancer effects in DMBA‐induced breast cancer in Wistar rats through X‐linked inhibitor of apoptosis protein (XIAP) antagonism and anti‐inflammation

Etiologic Role of Kinases in the Progression of Human Cancers and Its Targeting Strategies

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