Cancer statistics, 1990

Silverberg, Edwin; Boring, Catherine C.; Squires, T. S.

doi:10.3322/canjclin.40.1.9

Cited by 696 publications

(270 citation statements)

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“…Almost 50% of deaths from colorectal cancer occur in patients over 75 years of age (Silverberg et al, 1990) and the median age at diagnosis is around 68.4 years for rectal and 70.5 years for colon cancer (Young et al, 1981), the incidence of colorectal malignancy increasing steadily up to the eight decade (Winawer et al, 1984). A difference in the clinical presentation is being reported (Arnaud et al, 1991) as a consequence of a twofold increase in right-sided cancers, which are responsible for occult bleeding, occlusion and nutritional impairment.…”

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confidence: 99%

Elective surgery for colorectal cancer in the aged: a clinical-economical evaluation

Audisio

Cazzaniga²,

Robertson³

et al. 1997

Br J Cancer

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Summary A series of 56 consecutive patients, referred for surgery to a specialized institute, had elective laparotomies with various surgical procedures aimed at curing locoregional colorectal cancer. Data defining patient and tumour-related preoperative, operative and postoperative variables, including costs, were collected. The study group was divided into two age groups (< 65 vs . 65 years), which were similar in terms of patient-and tumour-related variables. Differences were not statistically significant (£440; 95% exact Cl; £ -50; 1800). There is no evidence to suggest that there are any total charge differences in treating the two age groups, as confirmed by the cost analysis.

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confidence: 99%

Elective surgery for colorectal cancer in the aged: a clinical-economical evaluation

Audisio

Cazzaniga²,

Robertson³

et al. 1997

Br J Cancer

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“…Prostatic adenocarcinoma is the fourth and second most common cause of cancer death among men in the UK (Davies & Eaton, 1991) and United States (Silverberg et al, 1990) (Waterhouse et al, 1982). Recent advances in molecular genetics of other prevalent tumours, such as colorectal (Vogelstein et al, 1988), bladder (Tsai et al, 1990), lung and breast cancers (Callahan & Cambell, 1989), indicate multiple genetic alterations by activation of oncogenes (see Bishop, 1991 for reviews) and, more importantly, the inactivation of tumour suppressor genes (see Marshall, 1991 (Carter et al, 1990c (Kaighn et al, 1979) and DU-145 (Stone et al, 1978), were obtained from the American Tissue Type Collection and used as positive controls.…”

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confidence: 99%

Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer

Uchida

Wada²,

Shitara³

et al. 1993

Br J Cancer

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Summary A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases. Two out of 21 prostate cancers (9.5%) were found to have p53 mutations. These were stage B2 and D2 prostate cancers. No abnormalities were found in the remaining cases or benign prostatic hyperplasia.Mutations of the p53 gene would thus appear infrequent in the tumourigenesis of primary prostate cancer.

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“…Ovarian cancer is the commonest cause of death from gynaecological cancer in the developed world (Silverberg et al, 1990;Booth & Beral, 1985). The age adjusted death rates from ovarian cancer have continued to increase since 1955 (Silverberg et al, 1990).…”

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confidence: 99%

“…The age adjusted death rates from ovarian cancer have continued to increase since 1955 (Silverberg et al, 1990). A major cause of the high mortality rate from ovarian cancer is the late presentation of the disease in over 60% of patients, with an associated 5-year survival rate of approximately 5% (Ozols et al, 1980).…”

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confidence: 99%

“…The most convincing factor to emerge as an influence on the development of ovarian cancer is hormonal. Several studies have shown that the risk of ovarian cancer in nulliparous women is 1.5-3.3 times greater than that of parous women (Silverberg et al, 1990;Piver, 1987). The 'incessant ovulation' hypothesis proposed initially by Fathalla (1971), and expanded by others (Casagrade et al, 1979) attempted to explain the protective effect of pregnancy as being due to the rest periods afforded by pregnancy from incessant ovulation.…”

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confidence: 99%

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