Cancer stem cell: A rogue responsible for tumor development and metastasis

Kapoor, Aditi; Kumar, Sudhir

doi:10.4103/0019-509x.146794

Cited by 16 publications

(6 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the development of CSCs purification and transplantation techniques, the hypotheses of CSC models have been further verified in many types of cancers. Both clinical and basic research have provided credible evidences in support of the presence and crucial biological functions of CSCs [ 167 , 168 , 169 ]. Investigation of CSCs provides potential novel targets for improving therapeutic efficacy of chemotherapy in cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds

Hong

Tan

et al. 2016

IJMS

View full text Add to dashboard Cite

The pivotal role of cancer stem cells (CSCs) in the initiation and progression of malignancies has been rigorously validated, and the specific methods for identifying and isolating the CSCs from the parental cancer population have also been rapidly developed in recent years. This review aims to provide an overview of recent research progress of Chinese medicines (CMs) and their active compounds in inhibiting tumor progression by targeting CSCs. A great deal of CMs and their active compounds, such as Antrodia camphorate, berberine, resveratrol, and curcumin have been shown to regress CSCs, in terms of reversing drug resistance, inducing cell death and inhibiting cell proliferation as well as metastasis. Furthermore, one of the active compounds in coptis, berbamine may inhibit tumor progression by modulating microRNAs to regulate CSCs. The underlying molecular mechanisms and related signaling pathways involved in these processes were also discussed and concluded in this paper. Overall, the use of CMs and their active compounds may be a promising therapeutic strategy to eradicate cancer by targeting CSCs. However, further studies are needed to clarify the potential of clinical application of CMs and their active compounds as complementary and alternative therapy in this field.

show abstract

Section: Discussionmentioning

confidence: 99%

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds

Hong

Tan

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…Tumors comprise heterogeneous groups of cells, in which a specific subpopulation of cancer stem cells (CSCs) is proposed to be responsible for tumorigenesis, resistance to therapy, and recurrence, leading to metastasis from primary sites to distant organs via epithelialto-mesenchymal transition (EMT) (Kapoor and Kumar 2014). This behavior has been attributed to the extensive self-renewal and multipotent differentiation abilities of CSCs, characteristics similar to those of other stem cells (Jordan et al 2006).…”

Section: Emerging Role: Stemness In Cscsmentioning

confidence: 99%

Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells

2016

Cell Stress and Chaperones

View full text Add to dashboard Cite

Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the HSP90 family, controls a variety of physiological functions, including cell proliferation, differentiation, and survival. Most studies have been devoted to understanding the anti-apoptotic roles of TRAP1 in cancer and targeting it for tumor control in clinical settings. Additionally, we have identified a new role for TRAP1 in regulation of liver regeneration after partial hepatectomy in TRAP1 transgenic mice and cellular proliferation in TRAP1-overexpressing cells, via mitochondrial alterations. Moreover, recent works have indicated a role for TRAP1 in the regulation of cancer stem cells (CSCs) as well as a metabolic switch between mitochondrial respiration and aerobic glycolysis called as BWarburg effect.^This review discusses the implications of TRAP1 action for both metabolism and the regulation of CSCs.

show abstract

“…However, the mechanisms that regulate these processes are deregulated; therefore, CSCs continuously expand and produce differentiated progeny (5)(6)(7). Furthermore, CSCs can form new form tumors when grown into animals, but normal stem cells are unable to do (8,9). CSCs compose a small population of cells within a tumor, share similar surface markers with normal stem cells (10,11) and share common signaling pathways with normal stem cells (12,13).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness

et al. 2020

View full text Add to dashboard Cite

The theory of cancer stem cells (CSCs) proposes that the different cells within a tumor, as well as metastasis deriving from it, are originated from a single subpopulation of cells with self-renewal and differentiation capacities. These cancer stem cells are supposed to be critical for tumor expansion and metastasis, tumor relapse and resistance to conventional therapies, such as chemo-and radiotherapy. The acquisition of these abilities has been attributed to the activation of alternative pathways, for instance, WNT, NOTCH, SHH, PI3K, Hippo, or NF-κB pathways, that regulate detoxification mechanisms; increase the metabolic rate; induce resistance to apoptotic, autophagic, and senescence pathways; promote the overexpression of drug transporter proteins; and activate specific stem cell transcription factors. The elimination of CSCs is an important goal in cancer therapeutic approaches because it could decrease relapses and metastatic dissemination, which are main causes of mortality in oncology patients. In this work, we discuss the role of these signaling pathways in CSCs along with their therapeutic potential.

show abstract

Cancer stem cell: A rogue responsible for tumor development and metastasis

Cited by 16 publications

References 101 publications

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds

Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells

Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness

Contact Info

Product

Resources

About