Cancer Stem Cells and Chemoresistance

Chuthapisith, Suebwong

doi:10.5772/13789

Cited by 3 publications

(2 citation statements)

References 52 publications

(50 reference statements)

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“…In pancreatic cancer, IL4 boosts the growth and its blockage has inhibitive effects [27]. The efficacy of chemotherapy may be enhanced when combined with anti-IL4 adjuvant treatment [28].…”

Section: Apoptosismentioning

confidence: 99%

A Review on the Biology of Cancer Stem Cells

Mansouri¹,

Reza²,

Gholamin³

2014

SCD

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Cancer Stem Cells (CSC) have the ability to self-renew and are present in most tissues including breast, brain, lung, prostates, testis, ovary, esophagus, colon, and liver. Their origin is yet to be discovered, though a series of hypotheses have been proposed in this regard. CSCs play a role in not only the creation of cancer, but also in its evolution, metastasis, and recurrence. CSCs have an important role in cancer therapy and the resistance towards chemotherapeutic agents. This article reviews the characteristics of cancer stem cells in terms of origin, resistance towards chemotherapy, methods of isolation, and cancer therapy.

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“…In pancreatic cancer, IL4 boosts the growth and its blockage has inhibitive effects [27]. The efficacy of chemotherapy may be enhanced when combined with anti-IL4 adjuvant treatment [28].…”

Section: Apoptosismentioning

confidence: 99%

A Review on the Biology of Cancer Stem Cells

Mansouri¹,

Reza²,

Gholamin³

2014

SCD

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“…It is still doubtful whether or not CSCs are fully dependent on the niche, like NSCs that vary in different types of tumors. [ 5 10 15 ]…”

Section: Introductionmentioning

confidence: 99%

Role of cancer stem cells in head-and-neck squamous cell carcinoma – A systematic review

et al. 2021

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Targeting cancer stem cell (CSC) subpopulation within the tumor remains an obstacle for specific therapy in head-and-neck squamous cell carcinoma (HNSCC). Few studies in the literature describe a panel of stem cell makers, however a distinct panel has not been put forth. This systematic review aims to enhance the knowledge of additional markers to accurately relate their expression to tumorigenesis, metastasis, and therapy resistance. Databases, including PubMed, Google Scholar, Ebsco, and Science Direct, were searched from 2010 to 2017 using various combinations of the following keywords: “Stem cell markers in HNSCC” and “chemoresistance and radioresistence in HNSCC.” Original experimental studies (both in vitro and in vivo ) published in English considering stem cell markers in HNSCC, were considered and included. We excluded articles on tumors other than HNSCC, reviews, editorial letters, book chapters, opinions, and abstracts from the analyses. Forty-two articles were included, in which 13 types of stem cell markers were identified. The most commonly expressed CSC markers were CD44, aldehyde dehydrogenase, and CD133, which were responsible for tumorigenesis, self-renewal, and therapy resistance, whereas NANOG, SOX-2, and OCT-4 were involved in metastasis and invasion. Identification of an accurate panel of CSC markers is the need of the hour as nonspecificity of the current markers poses a problem. Further studies with a large sample size would help validate the role of these CSC markers in HNSCC. These CSC proteins can be developed as therapeutic targets for HNSCC therapy, making future treatment modality more specific and effective.

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Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy

et al. 2016

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The repeated treatment of cancer cells with chemo- or radiotherapy induces therapy resistance, but it was previously unknown whether the same effect occurs upon continuous exposure of cancer cells to diet-derived chemopreventive agents. We elucidated this interesting question in pancreatic ductal adenocarcinoma, which is a highly aggressive cancer entity with a marked resistance toward gemcitabine and other cytotoxic drugs. The isothiocyanate sulforaphane, present in cruciferous vegetables, and the polyphenol quercetin, present in many fruits and vegetables induced apoptosis and reduced viability in gemcitabine-sensitive BxPC-3 cells but not in non-malignant ductal pancreas cells and mesenchymal stromal cells. In turn, BxPC-3 cells were treated with increasing concentrations of gemcitabine, sulforaphane or quercetin for more than 1 year and the surviving subclones Bx-GEM, Bx-SF and Bx-Q were selected, respectively. While Bx-GEM cells acquired a total resistance, Bx-SF or Bx-Q cells largely kept their sensitivity as proved by MTT assay, annexin staining and FACS analysis. The evaluation of the self-renewal-, differentiation- and migration-potential by colony formation, differentiation or migration assays demonstrated that cancer stem cell features were enriched in gemcitabine-resistant cells, but decreased in sulforaphane- and quercetin-long time-treated cells. These results were confirmed by orthotopic xenotransplantation of cancer cells to the mouse pancreas, where Bx-GEM formed large, Bx-Q small and Bx-SF cells almost undetectable tumors. An mRNA expression profiling array and subsequent gene set enrichment analysis and qRT-PCR confirmed that tumor progression markers were enriched in Bx-GEM, but reduced in Bx-SF and Bx-Q cells. This study demonstrates that the continuous exposure of pancreatic cancer cells to sulforaphane or quercetin does not induce resistance in surviving cells but reduces tumorigenicity by inhibition of tumor progression markers. These results highlight that cancer cells may not adapt to the preventive and therapeutic effects of a regular fruit- and vegetable-based diet.

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Cancer Stem Cells and Chemoresistance

Cited by 3 publications

References 52 publications

A Review on the Biology of Cancer Stem Cells

A Review on the Biology of Cancer Stem Cells

Role of cancer stem cells in head-and-neck squamous cell carcinoma – A systematic review

Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy

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