Cancer stem cells (CSCs): key player of radiotherapy resistance and its clinical significance

Hoque, Saminur; Dhar, Rajib; Kar, Rishav; Mukherjee, Sayantanee; Mukherjee, Dattatreya; Mukerjee, Nobendu; Nag, Sagnik; Tomar, Namrata; Mallik, Saurav

doi:10.1080/1354750x.2022.2157875

Cited by 21 publications

(16 citation statements)

References 239 publications

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“…The unexplained nature of exosomes has raised concerns about multiple events and their role in cancer cell angiogenesis and metastasis, including epithelial to mesenchymal transition (EMT) and immunological modulation . TEXs (tumor-derived exosomes) play an important role in the origin, development, and treatment resistance of cancer. , The discovery of exosomes, which serve as regulatory agents in cancer intercellular communication, increases the potential to investigate the understanding of tumor immunity. Several scientific studies suggest that tumor-associated macrophages (TAMs) are involved in major inflammation, suggesting that TAMs play a significant role in tumorigenesis .…”

Section: Exosomes For Cancer Theragnosticmentioning

confidence: 99%

“… 49 TEXs (tumor-derived exosomes) play an important role in the origin, development, and treatment resistance of cancer. 50 , 159 The discovery of exosomes, which serve as regulatory agents in cancer intercellular communication, increases the potential to investigate the understanding of tumor immunity. Several scientific studies suggest that tumor-associated macrophages (TAMs) are involved in major inflammation, suggesting that TAMs play a significant role in tumorigenesis.…”

Section: Exosomes For Cancer Theragnosticmentioning

confidence: 99%

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Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Kar

Dhar

Mukherjee

et al. 2023

ACS Biomater. Sci. Eng.

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102

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Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.

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Section: Exosomes For Cancer Theragnosticmentioning

confidence: 99%

Section: Exosomes For Cancer Theragnosticmentioning

confidence: 99%

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Kar

Dhar

Mukherjee

et al. 2023

ACS Biomater. Sci. Eng.

Self Cite

102

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“…This alteration leads malignant cell of CRC to metastasize to distant organs. , Exosomes miRNAs are involved in several complication of CRC such as metastasis (miRNA-203, miRNA-21, miRNA-375, miRNA-200, miRNA-429, miRNA-335, miRNA-132, and miRNA-192), − chemoresistance (miRNA-16, miR-30, miR-92, miRNA-100, miRNA-144), and drug resistance (methotrexate) . In addition, exosomes are also vital regulators of radiotherapy resistance …”

Section: Exosomes and Crc Metastasismentioning

confidence: 99%

Clinical Impact of Exosomes in Colorectal Cancer Metastasis

Ghosh¹,

Dhar

Shivji

et al. 2023

ACS Appl. Bio Mater.

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Cancer is a complex deadly disease that has caused a global health crisis in recent epochs. Colorectal cancer (CRC) is the third most common malignant gastrointestinal disease. It has led to high mortality due to early diagnostic failure. Extracellular vesicles (EVs) come with promising solutions for CRC. Exosomes (a subpopulation of EVs) play a vital role as signaling molecules in CRC tumor microenvironment. It is secreted from all active cells. Exosome-based molecular transport (DNA, RNA, proteins, lipids, etc.) transforms the recipient cell’s nature. In CRC, tumor cell-derived exosomes (TEXs) regulate multiple events of CRC development and progression such as immunogenic suppression, angiogenesis, epithelial–mesenchymal transitions (EMT), physical changes in the extracellular matrix (ECM), and metastasis. Biofluid-circulated tumor-derived exosomes (TEXs) are a potential tool for CRC liquid biopsy. Exosome-based colorectal cancer detection creates a great impact in CRC biomarker research. The exosome-associated CRC theranostics approach is a state-of-the-art method. In this review, we address the CRC and exosomes complex associated with cancer development and progression, the impact of exosomes on CRC screening (diagnostic and prognostic biomarkers), and also highlight several exosomes with CRC clinical trials, as well as future directions of exosome-based CRC research. Hopefully, it will encourage several researchers to develop a potential exosome-based theranostic tool to fight CRC.

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“…153 Exosomes also regulate therapeutic resistance development. 155 Exosome-based GBM drug delivery overcomes the limitations of the traditional drug delivery approach. Tumor cells infer the inner molecular diversity (miRNAs, proteins, etc.)…”

Section: Challenges Associated With Glioblastoma-associated Exosome T...mentioning

confidence: 99%

“…Current challenges in the diagnosis and therapy of glioblastoma molecular heterogeneity, lack of reliable biomarkers, not a capable blood–brain barrier, limited treatment, and high recurrence rate . Exosomes also regulate therapeutic resistance development . Exosome-based GBM drug delivery overcomes the limitations of the traditional drug delivery approach.…”

Section: Challenges Associated With Glioblastoma-associated Exosome T...mentioning

confidence: 99%

Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

Nag

Bhattacharya

Dutta

et al. 2023

ACS Biomater. Sci. Eng.

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Glioblastoma (GBM) is an aggressive type of cancer that has led to the death of a large population. The traditional approach fails to develop a solution for GBM's suffering life. Extensive research into tumor microenvironments (TME) indicates that TME extracellular vesicles (EVs) play a vital role in cancer development and progression. EVs are classified into microvacuoles, apoptotic bodies, and exosomes. Exosomes are the most highlighted domains in cancer research. GBM cell-derived exosomes participate in multiple cancer progression events such as immune suppression, angiogenesis, premetastatic niche formation (PMN), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), metastasis, cancer stem cell development and therapeutic and drug resistance. GBM exosomes also carry the signature of a glioblastoma-related status. The exosome-based GBM examination is part of the new generation of liquid biopsy. It also solved early diagnostic limitations in GBM. Traditional therapeutic approaches do not cross the blood−brain barrier (BBB). Exosomes are a game changer in GBM treatment and it is emerging as a potential platform for effective, efficient, and specific therapeutic development. In this review, we have explored the exosome−GBM interlink, the clinical impact of exosomes on GBM biomarkers, the therapeutics signature of exosomes in GBM, exosome-based research challenges, and future directions in GBM. Therefore, the GBM-derived exosomes offer unique therapeutic opportunities, which are currently under preclinical and clinical testing.

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Cancer stem cells (CSCs): key player of radiotherapy resistance and its clinical significance

Cited by 21 publications

References 239 publications

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Clinical Impact of Exosomes in Colorectal Cancer Metastasis

Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

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