Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions

Hurria, Arti; Jones, Lee W.; Muss, Hyman B.

doi:10.14694/edbk_156160

Cited by 26 publications

(12 citation statements)

References 59 publications

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“…The phenotype for aging is frailty, and among the criteria for frailty is fatigue (Fried et al, 2001). Aging may be accelerated with cancer and cancer therapy, and a consequence of this acceleration may be deterioration in cognitive function (Hurria, Jones, & Muss, 2016; Mandelblatt et al, 2013). Accelerated aging may be particularly relevant in women who have lower cognitive reserve and, therefore, greater vulnerability to insult related to cancer and cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer

Bender¹,

Merriman²,

Sereika³

et al. 2018

ONF

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OBJECTIVES This study identified women with unique trajectories of executive function, concentration, and visual working memory before and during adjuvant therapy for breast cancer, and examined phenotypic and genotypic predictors associated with subgroups. SAMPLE & SETTING 399 postmenopausal women, of whom 288 were women with early-stage breast cancer and 111 were women without breast cancer, matched on age and years of education to the women with breast cancer, and all at an urban cancer center. METHODS & VARIABLES A repeated-measures design was used; assessments occurred before adjuvant therapy and every six months post-therapy initiation. Group-based trajectory modeling determined subgroups. Multinomial logistic regression identified phenotypic and genotypic characteristics. RESULTS Three executive function and concentration trajectory subgroups were identified: low, moderate, and high; two visual working memory subgroups were identified: low and high. IMPLICATIONS FOR NURSING Advancing age, greater pretherapy fatigue, and poorer pretherapy cognitive function are associated with the low subgroups. DNA repair and oxidative stress mechanisms may be involved in the cognitive changes that women experience.

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Section: Discussionmentioning

confidence: 99%

Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer

Bender¹,

Merriman²,

Sereika³

et al. 2018

ONF

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“…42 The cumulative impact of these chronic and late effects of cancer may represent an acceleration of normal aging or the accumulation of comorbid diseases at an earlier age than their peers without a cancer history. 43,44 A significant number of long-term survivors (5 years or more), especially those who had more invasive and aggressive treatments, report lower overall physical well-being than their peers. 45 Over 50% of adult cancer survivors 46 and 65% of older adult survivors 12 experience persistent functional limitations many years beyond treatment.…”

Section: The Growth Of Cancer Survivorship Researchmentioning

confidence: 99%

Equitably improving outcomes for cancer survivors and supporting caregivers: A blueprint for care delivery, research, education, and policy

Alfano

Leach

Smith

et al. 2018

CA A Cancer J Clinicians

146

139

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Cancer care delivery is being shaped by growing numbers of cancer survivors coupled with provider shortages, rising costs of primary treatment and follow‐up care, significant survivorship health disparities, increased reliance on informal caregivers, and the transition to value‐based care. These factors create a compelling need to provide coordinated, comprehensive, personalized care for cancer survivors in ways that meet survivors’ and caregivers’ unique needs while minimizing the impact of provider shortages and controlling costs for health care systems, survivors, and families. The authors reviewed research identifying and addressing the needs of cancer survivors and caregivers and used this synthesis to create a set of critical priorities for care delivery, research, education, and policy to equitably improve survivor outcomes and support caregivers. Efforts are needed in 3 priority areas: 1) implementing routine assessment of survivors’ needs and functioning and caregivers’ needs; 2) facilitating personalized, tailored, information and referrals from diagnosis onward for both survivors and caregivers, shifting services from point of care to point of need wherever possible; and 3) disseminating and supporting the implementation of new care methods and interventions.

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“…Cancer, its treatment, and associated adverse effects may accelerate the physiologic or functional aging of cancer survivors. [3][4][5][6][7] Compared with the general population, cancer survivors are at an increased risk of comorbidities, and poor physical and psychosocial quality of life, especially physical functioning. [8][9][10][11] However, some studies have suggested that functional status and other aspects of health-related quality of life are similar between very long-term cancer survivors (eg, those with >15 years since diagnosis) and similarly aged individuals without a history of cancer.…”

Section: Introductionmentioning

confidence: 99%

Effects of cancer history on functional age and mortality

Blair

Jacobs

Demark‐Wahnefried

et al. 2019

Cancer

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Background Cancer, its treatment, and associated adverse effects may accelerate the functional aging of cancer survivors. In the current study, the authors used geriatric assessment (GA) to compare the functional age of long‐term cancer survivors with that of similarly aged women without a cancer history, and to examine whether functional age influences all‐cause mortality differently between these 2 groups. Methods Participants included 1723 cancer survivors and 11,145 age‐matched, cancer‐free women enrolled in the Iowa Women's Health Study in 1986 who completed the 2004 questionnaire (at ages 73‐88 years). GA domain deficits included ≥2 physical function limitations, ≥2 comorbidities, poor general health, poor mental health, and underweight. The risk of all‐cause mortality was estimated for deficits in each GA domain between 4 groups based on the cross‐classification of the presence and/or absence of cancer history and GA domain deficit (the referent group was cancer‐free women without a GA deficit). Results Both cancer history and GA domain deficits significantly predicted 10‐year mortality for all GA domains. Cancer survivors without deficits had a 1.3‐fold to 1.4‐fold risk of mortality, similar to the 1.1‐fold to 1.7‐fold risk noted among cancer‐free women with deficits (all P < .05). Cancer survivors with deficits were found to have the highest mortality risk for 4 of 5 domains (hazard ratio range, 1.6‐2.0). Mortality risk increased with the increasing number of GA deficits, which was greater in cancer survivors compared with cancer‐free women. Conclusions Even without GA deficits, cancer survivors appear to have an excess risk of death compared with women without cancer, and these deficits add to mortality risk. Interventions are needed to maintain or improve functional/physiological capacity as women age, especially in cancer survivors.

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Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions

Cited by 26 publications

References 59 publications

Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer

Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer

Equitably improving outcomes for cancer survivors and supporting caregivers: A blueprint for care delivery, research, education, and policy

Effects of cancer history on functional age and mortality

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