Candida isolates in tertiary hospitals in northeastern Brazil

Hinrichsen, Sylvia Lemos; Falcão, Érica; Vilella, Tatiana Aguiar Santos; Rêgo, Leandro Chaves; Lira, Conceição; Almeida, Luciana O.; Araújo, Carmem; Duarte, Marcelo; Lopes, Geraldo

doi:10.1590/s1517-83822009000200021

Cited by 13 publications

(12 citation statements)

References 25 publications

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“…Da mesma forma, a incidência de candidíase vaginal, que varia entre 20-30% das gestações, geralmente não produz complicações obstétricas 13 A leucocitose na admissão foi um sinalizador para a presença concomitante de colonização (p = 0,048), considerado principal fator de risco para a fungemia 5,[7][8][9][10][11][12] . Essa correlação nos faz aventar a hipótese de que os RNs considerados potencialmente infectados ao nascimento, seja por amniorrexe prematura, ITU, candidíase materna ou outros fatores, apresentam maior chance, devido à imaturidade do sistema imunológico, de estarem colonizados na admissão.…”

Section: Discussionunclassified

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Fungal colonization in newborn babies of very low birth weight: a cohort study

Pinhat¹,

Borba²,

Ferreira³

et al. 2012

J Pediatr (Rio J)

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Objectives: To learn about the profile of fungal colonization and related risk factors in premature newborns. Methods:Prospective cohort, from 04/01/2010 to 04/31/2011, with 44 patients admitted to the neonatal intensive care unit, born at the hospital maternity, weighing less than 1,500 g. On admission, data were collected on pre-natal care and childbirth. Clinical and laboratory information, nasal and rectal swabs, and peripheral blood cultures were collected on days 1,7,10 and 14 of stay in neonatal intensive care unit and then, every 7 days until discharge or death. For statistical analysis, we used chi-square test, Fisher exact test, Kaplan-Meier and logistic regression model. Results:The incidence of colonization was 13.5/1,000 patients/ day. The incidence of candidemia was 0.9/1,000 patients/day. The average hospitalization time was 30.5 days (± 20.27), and the onset of colonization occurred, in average, at 11.13 days (±8.82). Vaginal delivery was found to be an independent risk factor for the development of fungal colonization during hospitalization (p = 0.042, odds ratio = 4.38, 95% confidence interval [95%CI] = 1,13-16,99). Likewise, leukocytosis (> 30,000/mm 3 ) on admission was an indicator for the simultaneous presence of fungal colonization (p = 0.048). The presence of bronchopulmonary dysplasia tends to be a factor of higher probability for the development of colonization (p = 0.067). The most affected colonization site was the rectal mucosa: 89.09 versus 10.9% of the nasal mucosa. Conclusion:Vaginal delivery and leukocytosis over 30,000/mm 3 on admission were found to be risk factors for fungal colonization during hospitalization.J Pediatr (Rio J). 2012;88(3):211-6: Candidiasis, candidemia, prematurity, Neonatal Intensive Care Unit. ResumoObjetivos: Conhecer o perfil de colonização fúngica e os fatores de risco associados em recém-nascidos prematuros.Métodos: Coorte prospectiva, de 01/04/10 a 31/04/11, com 44 pacientes admitidos na unidade de terapia intensiva neonatal, nascidos na maternidade do hospital, com peso menor que 1.500 g. Na admissão, coletaram-se dados sobre pré-natal e parto. Informações clínico-laboratoriais, swabs nasal, retal e hemocultura periférica foram coletados nos dias 1, 7, 10 e 14 de permanência na unidade de terapia intensiva neonatal e, então, a cada 7 dias até alta ou óbito. Para análise estatística, utilizou-se teste qui-quadrado, exato de Fisher, curva de Kaplan-Meier e modelo de regressão logística.Resultados: A incidência de colonização foi de 13,5/1.000 pacientes/dia. A de candidemia foi de 0,9/1.000 paciente/dia. A média de internamento foi de 30,5 dias (±20,27), sendo o início da colonização, em média, aos 11,13 dias (±8,82). O parto vaginal foi um fator de risco independente para desenvolvimento de colonização fúngica ao longo da internação [p = 0,042; odds ratio = 4,38; intervalo de confiança de 95% (IC95%) = 1, [13][14][15][16]99]. Da mesma forma, a leucocitose (> 30.000/mm 3 ) na admissão foi um sinalizador para a presença concomitante de colonização...

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Section: Discussionunclassified

“…A transmissão pode se dar de forma vertical, durante o parto, na passagem pelo canal vaginal (principalmente C. albicans), ou de forma horizontal, pelas mãos dos profissionais de saúde (principalmente C. parapsilosis) 4,10,13 .…”

Section: Introductionunclassified

Fungal colonization in newborn babies of very low birth weight: a cohort study

Pinhat¹,

Borba²,

Ferreira³

et al. 2012

J Pediatr (Rio J)

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“…Fungal infections have increased in recent years, and are responsible for high morbidity and mortality rates. Candida still causes most of the fungal nosocomial infections; the presence of these yeasts in human microbiota favours the incidence of these infections, mainly due to the virulence factors of the fungus and its interaction with the hospitalized patients who presented a weak immune system (Hinrichsen et al, 2009;Heo et al, 2011;Silva et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent isolated specie was again C. albicans, found in 51.4% of the patients. C. albicansis without a doubt the most frequently isolated specie in both superficial and invasive infections from different anatomic sites, and the most common cause of candidiasis and candidemia worldwide (Moris et al, 2008;Hinrichsen et al, 2009;Savastano et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

et al. 2018

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The aim of this study was to evaluate the frequency of Candida species between a non-hospitalized and a hospitalized population. For this purpose, samples of saliva were sampled through sterile swabs, moistened in peptone water and rubbed in the oral cavity of 140 individuals, from which, 70 were hospitalized patients from the Medical Clinic of a Teaching Hospital and the other 70 were non-hospitalized subjects. All saliva samples were plated in Sabouraud Dextrose agar added with Chloramphenicol and incubated at 36 °C for 48 hours. The morphology identification was performed through macroscopic and microscopic characterization, the CHROMagar Candida medium and the VITEK  system Yeast Biochemical Card (bio Mérieux SA, France). The results showed a colonization of Candida spp. in 85.7% the hospitalized individuals, where the species found were C. albicans (60%), C. tropicalis (23.4%), C. krusei (3.3%) and Candida spp. (13.3%). In the non-hospitalized individuals the colonization by Candida spp was 47.1%, and the species found were: C. albicans (45.5%), C.krusei (9.1%), C. guilliermondii (9.1% %), C. tropicalis (3.0%), C. famata (3.0%) and Candida spp. (30.3%). In spite of their presence in oral cavity in both groups, Candida spp. was more frequently isolated in hospitalized individuals, who were 6.73 times more likely to have this fungus in the oral cavity and were 3.88 times more likely to have Candida albicans. Nos indivíduos não-hospitalizados a colonização por Candida spp foi de 47,1%, e as espécies encontradas foram: C. albicans (45,5%), C. krusei (9,1%), C. guilliermondii (9,1%), C. tropicalis (3,0%), C. famata (3,0%) e Candida spp. (30,3%). Apesar de sua presença na cavidade oral em ambos os grupos, Candida spp. foi mais freqüentemente isolada em indivíduos hospitalizados, que foram 6,73 vezes mais propensos a ter este fungo na cavidade oral e foram 3,88 vezes mais propensos a ter Candida albicans. KeywordsPalavras-chave: Candida spp. oral, colonização, pacientes hosptalizados, infecções hospitalares.

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“…Unfortunately, the increased survival rate of these high-risk infants has led to a concomitant rise in the incidence of Candida infections; over the past decade, the incidence of Candida parapsilosis has dramatically increased. In fact, reports indicate that C. parapsilosis is often the second most common Candida species isolated from blood cultures (Kuzucu et al, 2008;Hinrichsen et al, 2008;Pfaller et al, 2010;Aydin et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

An outbreak of Candida parapsilosis fungemia among preterm infants

Guo

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In this article, we describe the first outbreak of Candida parapsilosis fungemia in our hospital. We examined a cluster of four nosocomial cases of C. parapsilosis fungemia that occurred in the neonatal intensive care unit (NICU) of the Affiliated Xingtai People's Hospital of Hebei Medical University over a two-week period. We ascertained patient parameters including clinical characteristics, blood and sputum cultures, and drug sensitivity test results. Cultures from eight blood samples obtained from the four infected preterm infants showed identical characteristics and were identified as C. parapsilosis. In order to determine the infection-related factors and to control the spread of the infection among the population, we immediately initiated the emergency plan. All four of the preterm infants recovered from the infection; there 18260 W. Guo et al.

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Candida isolates in tertiary hospitals in northeastern Brazil

Cited by 13 publications

References 25 publications

Fungal colonization in newborn babies of very low birth weight: a cohort study

Fungal colonization in newborn babies of very low birth weight: a cohort study

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

An outbreak of Candida parapsilosis fungemia among preterm infants

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