Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City

Cruz, Miguel; Valladares‐Salgado, Adán; García-Mena, Jaime; Ross, Kelley; Edwards, Melissa; Angeles-Martínez, Javier; Ortega-Camarillo, Clara; Escobedo, Jorge; Burguete-García, Ana I.; Wacher, Niels H.; Ambriz, R; Rivera, Roberto; D'artote, A. L.; Peralta, Jesús; Parra, Esteban J.; Kumate, J

doi:10.1002/dmrr.1082

Cited by 103 publications

(80 citation statements)

References 71 publications

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“…Similarly, this polymorphism was found associated with diabetes in several works carried out in admixed populations from other Latin American countries (9,(23)(24)(25)28,29,31,32). However, Barros and cols.…”

Section: Discussionmentioning

confidence: 69%

“…2016;60/3 TCF7L2 (transcription factor 7-like 2) is among the highly replicated genes showing robust association with T2DM (8,9). The TCF7L2 gene spans 215.9 kb on chromosome 10q25.3, and its product is a high-mobility box-containing transcription factor involved in the Wnt signaling pathway (10).…”

Section: Tcf7l2 Polymorphisms and Type 2 Diabetes Riskmentioning

confidence: 99%

“…Moreover, among Latin American countries there are only reports on the association of TCF7L2 polymorphisms and T2DM from Colombia (23), Brazil (24)(25)(26)(27)(28) and Mexico (9,(29)(30)(31)(32). Latin American populations are characterized by high socioeconomic and genetic heterogeneity with varying degrees of ancestral population proportions from country to country, thus more studies are needed exploring the basis of T2DM susceptibility from these mixed populations.…”

Section: Tcf7l2 Polymorphisms and Type 2 Diabetes Riskmentioning

confidence: 99%

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Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans

Moran

Labrador

Camargo

et al. 2016

Arch. Endocrinol. Metab.

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Objective: The global burden of diabetes mellitus will impact strongly American countries in the coming decades. Type 2 diabetes mellitus (T2DM) is a multifactorial disease and the basis for its genetic susceptibility remains not fully understood. Different population studies have demonstrated that variants of the TCF7L2 gene are strongly associated with an increased risk of T2DM. Moreover, institutions or countries with limited budget to conduct genetic research need cost effective methods for detecting DNA variants. Subjects and methods: We standardized a rapid and simple allele-specific PCR method for genotyping the rs12255372 single nucleotide polymorphism (SNP) in a pilot study exploring the association of three TCF7L2 polymorphisms (rs7903146, rs12255372 and DG10S478) with T2DM in 70 patients and 73 controls from Venezuela. Results: The performance of the designed allele-specific PCR reaction for rs12255372 genotyping was reliable and accurate. Patients carrying the TCF7L2 rs7903146 T allele (CT + TT genotypes) and heterozygous CT genotype had a significantly higher risk for T2DM (OR = 2.9 and 2.3, respectively). Although rs12255372 and DG10S478 risk alleles predominated in T2DM group no statistical significance was found. Conclusions: We developed a novel allele-specific PCR method for easier and rapid detection of rs12255372 polymorphism without the use of expensive instrumentation and reagents. Our study in a relatively small sample of the Venezuelan population replicated the association of the rs7903146 SNP with T2DM. Further studies with larger sample size and more biochemical data should be conducted to explore the genetic basis of T2DM susceptibility in Venezuela. Arch Endocrinol Metab. 2016;60(3):246-51

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Section: Discussionmentioning

confidence: 69%

Section: Tcf7l2 Polymorphisms and Type 2 Diabetes Riskmentioning

confidence: 99%

Section: Tcf7l2 Polymorphisms and Type 2 Diabetes Riskmentioning

confidence: 99%

See 1 more Smart Citation

Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans

Moran

Labrador

Camargo

et al. 2016

Arch. Endocrinol. Metab.

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“…The subsequent genome-wide association analysis on T2DM showed a strong signal for TCF7L2 in the French population [23]. This prompted inclusion of TCF7L2 gene variants in a large number of association studies in various populations world-wide [24][25][26][27][28][29]. Furthermore, a number of meta-analyses supported this robust finding [30,31].…”

Section: Discussionmentioning

confidence: 94%

Związek między polimorfizmem rs7903146 genu TCF7L2 a nefropatią cukrzycową nie jest niezależny od cukrzycy typu 2 — badanie populacji Indii Południowych i metaanaliza

Hussain¹,

Ramachandran²,

Ravi³

et al. 2014

Endokrynologia Polska

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 TCF7L2 rs7903146 polymorphism and diabetic nephropathy association is not independent of type 2 diabetes -a study in a south Indian population and meta-analysis Związek między polimorfizmem rs7903146 genu TCF7L2 a nefropatią cukrzycową nie jest niezależny od cukrzycy typu 2 -badanie populacji Indii Południowych i metaanaliza AbstractDiabetic nephropathy (DN) is a chronic microangiopathic complication of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The TCF7L2 gene has been reported to be associated with type 2 diabetes risk. We aimed to investigate the impact of TCF7L2 gene on the susceptibility of T2DM and DN in a south Indian population. Plus to evaluate the association of rs7903146 in the TCF7L2 gene with T2DM in the Indian population. The subjects recruited for this included 55 diabetic cases with diabetic nephropathy, 68 diabetic cases without nephropathy, and 82 non-diabetic healthy controls. Genomic DNA was isolated from blood and genotyping of TCF7L2 rs7903146 was performed by PCR-RFLP analysis. A literature survey was carried out into the effect of rs7903146 on genetic susceptibility to T2DM in Indian populations and we then performed a meta-analysis in order to evaluate its association with T2DM. Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM. Meta-analysis showed that the mutant allele and genotypes are associated with T2DM in Indian populations. In summary, a significant association exists between the 'T' allele and DN, but this association is not independent of T2DM. Pooled meta-analysis of studies on rs7903146 and T2DM confirmed that rs7903146 is significantly associated with susceptibility to T2DM in Indian populations. (Endokrynol Pol 2014; 65 (4): 298-305) Key words: TCF7L2 gene; SNP; diabetic nephropathy StreszczenieNefropatia cukrzycowa (DN, diabetic nephropathy) jest przewlekłym powikłaniem o charakterze mikroangiopatii występującym zarówno w cukrzycy typu 1 (T1DM, type 1 diabetes mellitus), jak i typu 2 (T2DM, type 2 diabetes mellitus). Gen TCF7L2 jest związany z ryzykiem cukrzycy typu 2. Badanie przeprowadzono w celu dokonania oceny wpływu genu TCF7L2 na podatność na zachorowanie na T2DM i DN w populacji Indii Południowych oraz oceny związku między występowaniem polimorfizmu rs7903146 genu TCF7L2 i T2DM w populacji południowej części Indii. Do badania włączono 55 przypadków chorych na cukrzycę z nefropatią cukrzycową, 68 przypadków cukrzycy bez nefropatii i 82 osoby niechorujące na cukrzycę jako grupę kontrolną. Genomowe DNA izolowano z krwi i przeprowadzono genotypowanie polimorfizmu rs7903146 genu TCF7L2 metodą analizy PCR-RFLP. Przeprowadzono również przegląd literatury pod kątem danych dotyczących wpływu występowania polimorfizmu rs7903146 na genetyczną podatność na T2DM w populacji hinduskiej, a następnie przeprowadzono metaanalizę w celu oceny jego związku z T2DM. Analiza polimorfizmu r...

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“…However, inconsistent results on the association between the above variant alleles and T2DM risk may likely be due to the studies being carried out in individuals of different ethnicity [24,26]. The ADRB3 rs4994 polymorphism however, is reported to be associated with T2DM from Mexico city [27]. Moreover, Several past studies have connected this non-synonymous rs4994 polymorphism to T2DM, obesity, insulin resistance and hypertension [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Are we Predisposed to Type 2 Diabetes Risk: a Case-Control Study from Urban Population in Western India

Sheth¹

2017

EMIJ

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Background: Type 2 diabetes mellitus (T2DM) is driven by genetic and environmental factors. Sequence variants of candidate genes are known to predispose Indians to T2DM. ' Asian Indian Phenotype' is a cluster of abnormality described earlier; links possible genetic proneness of Indians. PPARγ2 gene SNP rs1801282, a missense variant is associated with improved insulin sensitivity, reduced T2DM risk and adipogenesis. This polymorphism does not confer this benefit to Indian Asians as seen in Caucasians. ADRβ3 gene SNP rs4994 produce variant receptor protein with altered affinity; is associated to development of dyslipidemia, obesity, insulin resistance (IR) and early T2DM onset. Combined influence of both these alleles on hemoglobin glycation, insulin resistance and dyslipidemia is not reported which is addressed in this case-control study from urban western Indian population.

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Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City

Cited by 103 publications

References 71 publications

Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans

Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans

Związek między polimorfizmem rs7903146 genu TCF7L2 a nefropatią cukrzycową nie jest niezależny od cukrzycy typu 2 — badanie populacji Indii Południowych i metaanaliza

Are we Predisposed to Type 2 Diabetes Risk: a Case-Control Study from Urban Population in Western India

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