Candidates selection for oocyte donation in a public gamete bank—Predictive value of the anti-Müllerian hormone

Abstract

Background:Infertility treatments with oocyte donation are becoming frequent. Recruitment of oocyte donors is a demanding and costly process and therefore of crucial importance. The selection of the oocyte donors undergoes a rigorous evaluation process of the candidates with routine measurement of the anti-Müllerian hormone (AMH) levels (ovarian reserve test). Our aim was to assess whether AMH levels could act as a good marker as tool to select the donor candidates and correlate them with the ovarian response to stimulation with a gonadotropin-releasing hormone antagonist protocol as well as to identify and validate the appropriate AMH level threshold by correlating it with the number of oocytes retrieved.Methods:A retrospective analysis of the oocyte donors' clinical records was performed.Results:The mean age of the participants was 27 years. The ovarian reserve evaluation showed a mean AMH of 5.20 ng/mL. An average number of 16 oocytes was retrieved (12 mature oocytes MII). AMH levels showed a statistically significant positive correlation with the number of total oocytes retrieved. A threshold value of AMH = 3.2 ng/mL predictive of the retrieval <12 oocytes (areas under the curve, 0.7364; 95% confidence interval: 0.529–0.944) was identified by receiver operating characteristic curve. Using this cutoff, the normal response (12 oocytes) was predicted with a sensitivity of 77% and a specificity of 60%.Conclusions:The measurement of AMH may be a determining factor in the choice of the oocyte donor candidates to maximize the response to requests from beneficiaries who require donor oocytes to perform assisted reproductive technique cycles.

Cut‐off value for anti‐Müllerian hormone in the diagnostic criteria for polycystic ovary syndrome in the Japanese population

“…Serum AMH levels of them were similar compared to those of healthy patients in other populations. 42,43 Furthermore, our multiple regression analysis showed that the serum AMH level is independently affected by the presence of PCOS and by age, in agreement with our previous report. 41 The number of follicles in every growing stage tends to be greater in women with PCOS than in healthy women, [44][45][46] which is remarkable in the small antral and pre-antral follicle stages.…”

“…In this study, the control group consisted of patients that initiated ART in the absence of ovulatory disorders. Serum AMH levels of them were similar compared to those of healthy patients in other populations 42,43 . Furthermore, our multiple regression analysis showed that the serum AMH level is independently affected by the presence of PCOS and by age, in agreement with our previous report 41 .…”

Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome

“…The current study lays the groundwork to validate AMH levels as a prognostic factor for pregnancy after IVF in women with PCOS, as AMH levels below 3.7 ng/mL were found to be associated with better pregnancy outcomes. This range of AMH values (under 3.5 ng/mL) is found among healthy women and has been linked with good ovarian response to stimulation [27][28][29]. Although this seems to be transversal to PCOS, the relationship between baseline AMH levels and pregnancy outcomes in women with PCOS may not be as straightforward and requires further investigation.…”

Female Reproductive Health – study of an egg donor population

“…(2021 ) predicted a cutoff level of 0.93 ng/mL. According to Vale-Fernandes et al (2023) , a threshold value of AMH = 3.2 ng/mL predictive of the retrieval <12 oocytes (areas under the curve, 0.7364; 95% confidence interval: 0.529-0.944) was identified by receiver operating characteristic curve. Using this cutoff, the normal response (12 oocytes) was predicted with a sensitivity of 77% and a specificity of 60%.…”