Candidemia in intensive care unit patients

Giri, Sidhartha; Kindo, Anupama Jyoti; Kalyani, J

doi:10.4103/0022-3859.118036

Cited by 29 publications

(28 citation statements)

References 25 publications

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“…In our study, all strains were susceptible to amphotericin B, which is in line with the findings of some previous studies [30, 31]. However, inconsistent with this finding, several studies reported a few amphotericin B-resistant strains isolated from the patients with candidemia [32, 33].…”

Section: Discussionsupporting

confidence: 91%

Candidemia in patients with prolonged fever in Kashan, Iran

et al. 2016

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Background and Purpose: Candida species are considered a common cause of fungal blood stream infections, which are associated with considerable mortality and morbidity rates, especially in the admitted and immunocompromised patients. Despite the increase in new and available antifungal agents, the emergence of resistant strains is growing. Regarding this, the aim of the present study was to assess the fungal epidemiology of candidemia and the antifungal susceptibility patterns against five current antifungal agents among the patients with prolonged fever, who were admitted to Beheshti Educational Hospital, Kashan, Iran.Materials and Methods:This cross-sectional study was conducted on 253 hospitalized patients with prolonged fever despite receiving broad-spectrum antibiotic therapy. Blood samples were collected aseptically, and then cultured using an automated blood culture system and conventional broth culture bottle. Candida isolates were identified at species level using morphological and physiological properties and produced color on the CHROMagar Candida. Furthermore, the antifungal susceptibility testing was performed using (CLSI M27-A3 and CLSI M27-S4) broth microdilution methods.Results:The most positive cultures were detected by the automated blood culture system. C. albicans (%50) was the most prevalent species, followed by C. glabrata (%40), and C. parapsilosis, (%10) respectively .The mortality rate was high (%60) and most patients with candidemia were admitted to the Intensive Care Unit and Neonatal Intensive Care Unit. All isolates were susceptible to amphotericin B, while the highest resistance belonged to caspofungin.Conclusion:In this study, high resistance was reported, especially for caspofungin, which can be regarded as the emergence of caspofungin-resistant strains. Regarding this, the establishment of a surveillance and prevention program for the reduction of the emergence of resistant species is necessary.

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Section: Discussionsupporting

confidence: 91%

Candidemia in patients with prolonged fever in Kashan, Iran

et al. 2016

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“…Several studies done in India shows prevalence rate of Candidemia varies from 0.65% to 6.9% (Giri et al, 2013;Verma et al, 2003;Sanhi et al, 2005;Deorukhkhar et al, 2012) (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Candida Species and its Antifungal Susceptibility Isolated from Blood Culture at Tertiary Care Hospital, Ahmedabad, India

Gandhi¹,

Patel²

2017

Int.J.Curr.Microbiol.App.Sci

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“…In North America, Northern Europe and North China, Candida albicans is followed by C. glabrata as the most common cause of candidaemia in contrast to the higher prevalence of C. parapsilosis and C. tropicalis than C. glabrata in Southern Europe and Latin America . Although C. albicans is reported as the main cause of candidaemia worldwide, several reports from India, indicated C. tropicalis as the most prevalent candidaemia‐causing species . Moreover, it has been shown that the species distribution can also vary on a regional scale and even on a local scale within the hospital …”

Section: Introductionmentioning

confidence: 99%

Increasing candidaemia incidence from 2004 to 2015 with a shift in epidemiology in patients preexposed to antifungals

Goemaere

Becker

Wijngaerden

et al. 2017

Mycoses

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SummaryCandidaemia is an important health problem in immunocompromised patients with an epidemiology varying with region, period and patient population involved. The occurrence of candidaemia and the associated species distribution over a 12-year period at a large tertiary care centre in Belgium were analysed. The trend in incidence in the intensive care units (ICUs) and non-ICUs was investigated as well as the influence of antifungal exposure on the species distribution. From 2004 until 2015, 865 candidaemia episodes occurred in 826 patients at the University Hospitals Leuven. Candida albicans (59%) remained the most important cause of candidaemia, followed by C. glabrata (22.4%) and C. parapsilosis (8%). The mean incidence in the whole hospital was 1.48 per 10 000 patient days (PD). The incidence in ICUs increased reaching up to 10.7 per 10 000 PD whereas in the non-ICUs, the incidence decreased. Prior exposure to fluconazole and echinocandins was associated with candidaemia caused by less susceptible species. Candidaemia incidence increased in the whole hospital, driven by ICUs. Surveillance of candidaemia epidemiology on a local scale is of high value to guide empirical treatment strategies. K E Y W O R D Santifungal agents, Candida spp., candidaemia, epidemiology, incidence

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Candidemia in intensive care unit patients

Cited by 29 publications

References 25 publications

Candidemia in patients with prolonged fever in Kashan, Iran

Candidemia in patients with prolonged fever in Kashan, Iran

Prevalence of Candida Species and its Antifungal Susceptibility Isolated from Blood Culture at Tertiary Care Hospital, Ahmedabad, India

Increasing candidaemia incidence from 2004 to 2015 with a shift in epidemiology in patients preexposed to antifungals

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