Canine Mixed Tumours

Jabara, Anne G.

doi:10.1111/j.1751-0813.1960.tb08593.x

Cited by 13 publications

(16 citation statements)

References 20 publications

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“…1,7,8,10,13 Breed and age appear to be significant factors in the development of mammary tumors in the male dogs of this study. Nine of 18 were spaniels, and 3 were terrier breeds.…”

Section: Discussionmentioning

confidence: 93%

“…This is similar to previous reports of mammary neoplasia in dogs, both male and female, in which Cocker Spaniels, terrier breeds, and poodles appear to be overrepresented. 1,7,8,10,13 This is not surprising, given that heredity has been found to play a pivotal role in mammary cancer in humans, where a family history of breast cancer in first-degree relatives is commonly reported. 16 The average age of onset for the tumors in our study was 9.2 years, which is within the range of age of onset reported in most female dogs (6-10 years).…”

Section: Discussionmentioning

confidence: 99%

“…This predilection for the caudal mammary glands has been attributed to the greater mass of mammary tissue in these glands as well as greater potential for injury attributable to the more pendulous nature of these glands. 7,10,13 The higher prevalence of mammary tumors in the caudal glands in male dogs may also be attributable to increased mass of mammary tissue in which a tumor might arise, although male mammary tissue is composed of only ductal elements and is devoid of fully developed terminal duct lobular units. 14 All tumors in this study were well circumscribed and had benign histologic features.…”

Section: Discussionmentioning

confidence: 99%

“…16 The average age of onset for the tumors in our study was 9.2 years, which is within the range of age of onset reported in most female dogs (6-10 years). 1,7,10 Like mammary tumors in female dogs, most of the tumors for which location was specified occurred in the third through the fifth sets of glands. This predilection for the caudal mammary glands has been attributed to the greater mass of mammary tissue in these glands as well as greater potential for injury attributable to the more pendulous nature of these glands.…”

Section: Discussionmentioning

confidence: 99%

“…3,5,[9][10][11]15 Previous reports of mammary neoplasms in male dogs included the following diagnoses: ductal papillary adenoma, carcinoma, adenocarcinoma perithelioma, papillary cystadenocarcinoma, chondroadenocarcinoma, adenocarcinoma, cystic carcinoma, mixed tumor, osteosarcoma, sarcocarcinoma, cystadenochondroma, complex adenoma, simple adenoma, papillary cystadenoma with squamous cell carcinoma, benign mixed tumor, malignant mixed tumor, fibroadenoma, and spindle cell sarcoma. 5,[7][8][9][10]12,13,17 Mammary cancer in men is similarly rare, accounting for less than 1% of all breast carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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Histologic, Immunohistochemical, and Clinical Features of 27 Mammary Tumors in 18 Male Dogs

Bearss

Schulman

Carter³

2011

Vet Pathol

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Twenty-seven mammary tumors from 18 male (3 intact, 15 neutered) dogs were collected. The average age at diagnosis was 9.2 years (range, 2-14 years). Seven of the dogs were Cocker Spaniels. Five dogs had multiple mammary tumors. All tumors were benign. Twenty-six were simple adenomas with mixed acinar and papillary patterns. The acinar pattern was predominant in 17 cases. One adenoma was complex with a prominent myoepithelial component. The myoepithelial component of 25 of the 25 tumors was immunohistochemically positive for calponin and p63. In the cases for which relevant clinical information was available, there was no reported history of obesity, testicular tumors, or sex hormone therapy. Surgery was the only reported treatment for these tumors. Only 1 dog was reported to have developed an additional mammary tumor. None of the dogs for which case outcome was known died or was euthanatized as a result of mammary tumor. Although uncommon, mammary tumors do occur in male dogs. Although mammary tumors may be quite cellular, the presence of an intact myoepithelium, which can be demonstrated with immunohistochemistry for calponin and p63, indicates benignancy, as the clinical behavior documents.

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“…1,7,8,10,13 Breed and age appear to be significant factors in the development of mammary tumors in the male dogs of this study. Nine of 18 were spaniels, and 3 were terrier breeds.…”

Section: Discussionmentioning

confidence: 93%