Canine parvovirus type 2c in Vietnam continues to produce distinct descendants with new mutations restricted to Vietnamese variants

Doan, Huong Thi Thanh; Le, Xuyen Thi Kim; Thi, Roan; Nguyen, Khue Thi; Le, Thanh Hoa

doi:10.1007/s00705-021-05059-1

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…There was an uncommon N115D mutation in the NS2 protein of the HN-019, HN-056, HN-057, and HN-058 mutants. Currently, the CPV-2c variant carrying the VP2 I447M mutation mainly appeared in Vietnam and has been present in Vietnamese dogs since about 2017 ( 53 , 54 ), and the NS2 N115D mutation was only found in one Vietnamese CPV-2c strain (GenBank no. MT106238 ; collection date, 2017).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Characteristics of Canine Parvovirus Type 2 in Henan Province, China

Cheng

et al. 2022

Microbiol Spectr

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Section: Discussionmentioning

confidence: 99%

Prevalence and Characteristics of Canine Parvovirus Type 2 in Henan Province, China

Cheng

et al. 2022

Microbiol Spectr

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“…In addition to the mutation of VP2-5 and VP2-370, Thai CPV-2c containing isoleucine substitution mutation at VP2-447 amino acid residue has continued to increase in the past few years. Coincidently, a rise in CPV-2c variant with mutated VP2-447 was also reported in Vietnam, a Southeast Asian country close to Thailand [22,23]. We speculate that the CPV-2c variant with mutated VP2-447 might spread locally between Thailand and Vietnam through dog importation.…”

Section: Discussionmentioning

confidence: 54%

“…In North and South America, except in Colombia and Canada, CPV-2c is the most common variant. Most countries in Asia, Europe, and Oceania have the CPV-2a variant dominantly distributed, except Japan, Australia, and New Zealand where the CPV-2b variant is prevailing [21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand

et al. 2022

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Canine parvovirus type 2 (CPV-2) is responsible for hemorrhagic gastroenteritis in dogs worldwide. High genomic substitution rates in CPV-2 contribute to the progressive emergence of novel variants with increased ability to evade the host immune response. Three studies have analyzed the genomic mutations of CPV-2 variants in Thailand. These investigations were independently conducted at different timepoints. Thus, a retrospective integrated analysis of CPV-2 genomic mutations has not been fully performed. Our study aimed at evaluating the evolutionary changes in CPV-2 in Thailand from 2003 to 2019. Two hundred and sixty-eight Thai CPV-2 nucleotide sequences were used for multiple amino acid sequence alignment and phylogenetic analyses. From 2003 to 2010, CPV-2a and -2b were the only variants detected. CPV-2c, emerged in 2014, replacing CPV-2a and -2b, and has become a major variant in 2019. Phylogenetic analysis revealed that the proposed mutation pattern of VP2 amino acid residues could help distinguish Thai CPV-2 variants. This comprehensive examination provides insight into the genomic evolution of CPV-2 in Thailand since its first reporting in 2003, which may facilitate the surveillance of the potential genetic alteration of emergent CPV-2 variants.

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“…Currently, a third subtype of CPV called CPV type 2c has been documented in several countries. These include Australia (Woolford et al, 2017), Germany (Decaro et al, 2007), Italy (Mira et al, 2019), Vietnam (Doan et al, 2021), Taiwan (Chiang et al, 2016), the United States (Kapil et al, 2007) and Türkiye (Timurkan & Oguzoglu, 2015;Temizkan & Temizkan, 2023). According to earlier field research, the most common variants in Turkey are CPV-2a and CPV-2b, with CPV-2c showing an extremely remarkable increase in the prevalence in the last several years (Akkutay-Yoldar & Koc, 2020;Dik et al, 2022;Polat et al, 2019;Timurkan & Oguzoglu, 2015).…”

Section: F I G U R Ementioning

confidence: 99%

First identification of canine parvovirus ‐2a/2b variant in unvaccinated domestic dogs with gastrointestinal signs in Türkiye

SALTIK,

KOÇ

2024

Veterinary Medicine & Sci

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BackgroundCanine parvovirus type 2 (CPV‐2) is the most common enteric virus that infects canids. CPV is the causative agent of a contagious disease defined mostly by clinical gastrointestinal signs in dogs. During the late 1970s, CPV‐2 emerged as a new virus capable of infecting domestic dogs and growing across the world. The VP2 gene stands out as a key determinant in the pathogenicity, antigenicity, and host interactions of CPV‐2.AimsThe molecular characterization of the VP2 gene is crucial for understanding CPV evolution and epidemiology.Materials & MethodsGenes encoding the VP2 protein were sequenced and compared to reference strains worldwide. The maximum likelihood method was used to build a phylogenetic tree using CPV VP2 gene nucleotide sequences.ResultsOur phylogenetic analysis of the VP2 gene revealed that five strains were very similar and clustered together, and three strains were in the 2b clade, whereas the other two were in the 2a/2b clade.DiscussionThis paper reports the molecular characterization of two novel CPV‐2a/2b subtypes in dogs with gastrointestinal symptoms. Genetic analysis was conducted on a CPV genomic region encompassing one of the open reading frames (ORFs) encoding the structural protein VP2. Sequence analysis indicates new and unreported sequence changes, mainly affecting the VP2 gene, which includes the mutations Ser297Ala and Leu87Met. This study represents the first evidence of a new CPV‐2a/2b subtype in Türkiye. Due to VP2's crucial role in encoding the capsid protein of CPV‐2 and its significant involvement in the host‐virus interaction, it is critical to closely monitor its evolutionary changes and be cautious while searching for novel or pre‐existing subtypes.ConclusionThis study highlights the significance of continuous molecular research for acquiring more insights on the circulation of novel CPV mutants.

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Canine parvovirus type 2c in Vietnam continues to produce distinct descendants with new mutations restricted to Vietnamese variants

Cited by 8 publications

References 45 publications

Prevalence and Characteristics of Canine Parvovirus Type 2 in Henan Province, China

Prevalence and Characteristics of Canine Parvovirus Type 2 in Henan Province, China

Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand

First identification of canine parvovirus ‐2a/2b variant in unvaccinated domestic dogs with gastrointestinal signs in Türkiye

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