Canine Reference Intervals for Coagulation Markers Using the STA Satellite® and the STA-R Evolution® Analyzers

Geffré, Anne; Grollier, Sophie; Hanot, Camille; Vergez, François; Trumel, Catherine; Braun, Jean‐Pierre

doi:10.1177/104063871002200503

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…All other measurements were performed within 2 weeks of shipment, with the exception of 10 specimens processed within 2 months. Quality controls were performed according to the CLSI recommendations and the laboratory's standard procedures . Descriptions of used methods and the inter‐assay coefficient of variation are shown in Table .…”

Section: Methodsmentioning

confidence: 99%

Breed‐specific biochemical reference intervals for the adult Dogue de Bordeaux

Lavoué

Geffré

et al. 2013

Veterinary Clinical Pathol

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Specific reference intervals for biochemical analytes in the Dogue de Bordeaux were determined under controlled pre-analytical and analytical conditions, and according to international recommendations. The use of these breed-specific reference intervals is recommended when using the specified analytic instruments, especially for the 6 analytes for which the reference intervals differed considerably from those provided by manufacturers.

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Section: Methodsmentioning

confidence: 99%

Breed‐specific biochemical reference intervals for the adult Dogue de Bordeaux

Lavoué

Geffré

et al. 2013

Veterinary Clinical Pathol

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“…Results may be expressed as% of a pooled normal human or species‐specific specimen (eg, antithrombin activity), and reference intervals are then provided as a % of pooled normal human or species‐specific control, respectively . Specimens from animal patients and species‐specific control materials should be tested in duplicate.…”

Section: Primary and Secondary (Coagulation) Hemostasis Testingmentioning

confidence: 99%

ASVCP quality assurance guidelines: control of preanalytical and analytical factors for hematology for mammalian and nonmammalian species, hemostasis, and crossmatching in veterinary laboratories

Vap

Harr²,

Arnold

et al. 2012

Veterinary Clinical Pathol

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: In December 2009, the American Society for Veterinary Clinical Pathology (ASVCP) Quality Assurance and Laboratory Standards committee published the updated and peer‐reviewed ASVCP Quality Assurance Guidelines on the Society's website. These guidelines are intended for use by veterinary diagnostic laboratories and veterinary research laboratories that are not covered by the US Food and Drug Administration Good Laboratory Practice standards (Code of Federal Regulations Title 21, Chapter 58). The guidelines have been divided into 3 reports: (1) general analytical factors for veterinary laboratory performance and comparisons; (2) hematology, hemostasis, and crossmatching; and (3) clinical chemistry, cytology, and urinalysis. This particular report is one of 3 reports and provides recommendations for control of preanalytical and analytical factors related to hematology for mammalian and nonmammalian species, hemostasis testing, and crossmatching and is adapted from sections 1.1 and 2.3 (mammalian hematology), 1.2 and 2.4 (nonmammalian hematology), 1.5 and 2.7 (hemostasis testing), and 1.6 and 2.8 (crossmatching) of the complete guidelines. These guidelines are not intended to be all‐inclusive; rather, they provide minimal guidelines for quality assurance and quality control for veterinary laboratory testing and a basis for laboratories to assess their current practices, determine areas for improvement, and guide continuing professional development and education efforts.

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“…This is consistent with the notably different reference intervals of the 2 laboratories, and is likely due principally to the reagents used. For PT, validation would have been accepted in 4 of 25 cases, whereas the upper limit of the donor laboratory was 0.7 sec lower than in the current study, 5 which might cause clinical misinterpretations.…”

Section: <!?Show "Fnote_aff1"$^!"content-markup(/author-grp[1]/aff|/author-grp[1]/dept-list)>mentioning

confidence: 99%

“…The current study was therefore designed to test the soundness of transferring hemostasis reference intervals, and more specifically, the effects of the composition of the small reference sample group used by the receiving laboratory. It is based on previously published reference intervals of canine hemostasis in 56 dogs 1 (used herein as donor laboratory data) and individual results obtained in a previous study 5 (used herein to represent the procedure in the receiving laboratory). The variables studied were antithrombin (AT), prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen.…”

Section: <!?Show "Fnote_aff1"$^!"content-markup(/author-grp[1]/aff|/author-grp[1]/dept-list)>mentioning

confidence: 99%

“…Preanalytical conditions also differed, but in both cases the stability of the specimens had been validated. 1,5 Comparison of demographic conditions showed that a variety of breeds was used in both studies, and that there was a larger age range and a higher proportion of females in the receiving laboratory.…”

Section: <!?Show "Fnote_aff1"$^!"content-markup(/author-grp[1]/aff|/author-grp[1]/dept-list)>mentioning

confidence: 99%

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Validation of Preexisting Reference Intervals: Can the Procedure be Applied to Canine Hemostasis?

et al. 2011

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Abstract. The de novo establishment of reference intervals (RIs) for all variables is beyond the capabilities of many small laboratories. Thus, recent international recommendations propose procedures to adopt RIs established by ''donor'' laboratories after validation in ''receiving'' laboratories. The objective of the current study was to use recently published RIs of canine hemostasis tests as possible donor values and evaluate the validation procedure with randomized sets of values obtained in another study of canine RI determination of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and antithrombin (AT). The preanalytical, analytical, and demographic conditions of the donor and receiving laboratories were first compared. To represent new reference individuals, 25 validation sample sets of 20 results of the receiving laboratory were randomly selected for each variable and compared with the RI of the donor laboratory. Validation was rejected in all cases for APTT and AT. Donor RI could be validated in 14 of 25 cases for fibrinogen and in 4 of 25 cases for PT. When preanalytical and analytical differences existed between donor and receiving laboratories, validation procedures consistently rejected preexisting RI. When the differences are smaller, the variability of the results obtained in the validation sample sets tested may be responsible for validations or rejections, which can lead to further misinterpretations of results from patients. Validation of a preexisting reference interval is certainly an interesting option for small laboratories, but progressive determination of the laboratory's own reference interval is probably a better long-term solution.

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Canine Reference Intervals for Coagulation Markers Using the STA Satellite® and the STA-R Evolution® Analyzers

Cited by 10 publications

References 12 publications

Breed‐specific biochemical reference intervals for the adult Dogue de Bordeaux

Breed‐specific biochemical reference intervals for the adult Dogue de Bordeaux

ASVCP quality assurance guidelines: control of preanalytical and analytical factors for hematology for mammalian and nonmammalian species, hemostasis, and crossmatching in veterinary laboratories

Validation of Preexisting Reference Intervals: Can the Procedure be Applied to Canine Hemostasis?

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