2022
DOI: 10.3389/fped.2022.862035
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Cannabidiol Reduces Inflammatory Lung Damage After Meconium Aspiration in Newborn Piglets

Abstract: AimTo assess the effects of cannabidiol (CBD) on lung damage in a piglet model of meconium aspiration syndrome (MAS).Materials and MethodsMeconium aspiration syndrome was modelled in newborn piglets via intratracheal instillation of 20% meconium in saline collected from healthy newborn humans. Piglets were treated i.v. with 5 mg/kg CBD (MAS + CBD) or Vehicle (MAS + VEH) 30 min after MAS induction and monitored for 6 h. Ventilated piglets without meconium instillation served as controls (CTL). Ventilatory and h… Show more

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