Cannabinoid Receptor Agonist Namisol Does Not Affect Cytokine Levels In Chronic Pancreatitis Patients

Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids

“…All things considered, a central role of inflammation in the pathogenesis of CP is implied. While we have previously shown that levels of the proinflammatory cytokine TNFα are increased in patients with CP, we did not observe an effect on Namisol ® intake on serum cytokine levels (Utomo et al, 2015). The current study suggests that Namisol ® may provide acute anti-inflammatory relief through down modulation of innate and adaptive inflammatory signaling.…”

Effect profile of paracetamol, Δ9‐THC and promethazine using an evoked pain test battery in healthy subjects

“…Paracetamol 1000 mg is within the labelled dose range in the European Union (EU) and has been shown to be effective in reducing various types of pain. The currently used formulation of Δ9‐THC (Namisol ® , Echo Pharmaceuticals) has been administered in multiple studies including healthy volunteers (Klumpers et al., ) and different patient populations (Ahmed et al., ; Utomo et al., ; van Amerongen et al., ). Δ9‐THC has potential side effects, but is generally considered well‐tolerated, even in high dosages.…”

Severity and outcomes of acute alcoholic pancreatitis in cannabis users

“…In a randomized doubleblind placebo-controlled study on patients with chronic pancreatitis, it was demonstrated that Namisol (a pure and natural THC) did not affect the levels of pro-inflammatory cytokines TNF-α and IL-8 from their baseline levels. Similarly, levels of anti-inflammatory cytokine IL-10 remained unaffected (35). Recently, in another randomized, double-blind, placebo-controlled two-way crossover study in patients with chronic pancreatitis, a single dose of 8 mg Namisol failed to effectively reduce persistent abdominal pain when compared with diazepam (36).…”