Cannabinoids in Neuroinflammation, Oxidative Stress and Neuro Excitotoxicity

M, Sergio RC Gallegos

doi:10.4172/2153-2435.1000346

Cited by 5 publications

(1 citation statement)

References 68 publications

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“…THC is an active ingredient of cannabis plant that induces psychoactive effects, augments oxidative stress, and produces mitochondrial dysfunction in the brain, conditions that increase the risk to stroke and brain damage. 29,30 For these reasons, low interest exists about THC as an antiseizure drug.…”

Section: Hope For Drug-resistant Epilepsy?mentioning

confidence: 99%

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?

Rocha¹,

Frías‐Soria²,

Ortíz

et al. 2020

Epilepsia Open

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Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary to identify the types of epilepsies that can be controlled by these components and the mechanisms involved in these effects. This review presents a summary of the discussion carried out during the 2nd Latin American Workshop on Neurobiology of Epilepsy entitled “Cannabinoid and epilepsy: myths and realities.” This event was carried out during the 10th Latin American Epilepsy Congress in San José de Costa Rica (September 28, 2018). The review focuses to discuss the use of CBD as a new therapeutic strategy to control drug‐resistant epilepsy. It also indicates the necessity to consider the evaluation of unconventional targets such as P‐glycoprotein, to explain the effects of CBD in drug‐resistant epilepsy.

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Section: Hope For Drug-resistant Epilepsy?mentioning

confidence: 99%

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?

Rocha¹,

Frías‐Soria²,

Ortíz

et al. 2020

Epilepsia Open

View full text Add to dashboard Cite

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High Concentrations of Cannabidiol Induce Neurotoxicity in Neurosphere Culture System

Romariz,

Sanabria,

da Silva

et al. 2024

Neurotox Res

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Recent studies have demonstrated that cannabinoids are potentially effective in treating various neurological conditions, and cannabidiol (CBD), one of the most studied compounds, has been proposed as a non-toxic option. However, the adverse effects of CBD on neurodevelopmental processes have rarely been studied in cell culture systems. To gain a better understanding of CBD's impact on neuraldevelopment, we exposed neural progenitor cells (NPCs) to different concentrations of CBD (1 µM, 5 µM, and 10 µM) and investigated the morphology, migration, differentiation, cell death, and gene expression in 2D and 3D bioprinted models. Our results showed that CBD was more toxic at higher concentrations (5 µM and 10 µM) and affected the viability of NPCs than at lower concentration (1µM), in both 2D and 3D models. Moreover, our study identi ed that higher concentrations of CBD drastically reduced the size of neurospheres and the number of NPC within neurospheres, impaired the morphology and mobility of neurons and astrocytes after differentiation, and reduced neurite sprouting. Interestingly, we also found that CBD alters cellular metabolism by in uencing the expression of glycolytic and βoxidative enzymes in the early and late stages of metabolic pathways. Therefore, our study, demonstrated that higher concentrations of CBD promote important changes in cellular functions that are crucial during CNS development.

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The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration

Kajero

Seedat

Ohaeri

et al. 2022

Acta Neuropsychiatr.

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Objectives: We investigated the influence of oral cannabidiol (CBD) on vacuous chewing movements (VCM) and oxidative stress parameters induced by short- and long-term administration of haloperidol, in a rat model of tardive dyskinesia (TD). Methods: Haloperidol was administered either sub-chronically via the intraperitoneal (IP) route or chronically via the intramuscular (IM) route to six experimental groups, only or in combination with CBD. VCM and oxidative stress parameters were assessed at different time points after the last dose of medication. Results: Oral CBD (5mg/kg) attenuated the VCM produced by sub-chronic administration of haloperidol (5mg/kg) but had minimal effects on the VCM produced by chronic administration of haloperidol (50mg/kg). In both sub-chronic and chronic haloperidol groups, there were significant changes in brain antioxidant parameters compared with CBD only and the control groups. The sub-chronic haloperidol only group had lower GSH activity compared with sub-chronic haloperidol before CBD and the control groups; also, superoxide dismutase (SOD), catalase (CAT) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) activities were increased in the sub-chronic (IP) haloperidol only group compared with the CBD only and control groups. Nitric oxide (NO) activity was increased in sub-chronic haloperidol only group compared to the other groups, however, the chronic haloperidol group had increased MDA activity compared to the other groups. Conclusions: Our findings indicate that CBD ameliorated VCM in the sub-chronic haloperidol group before CBD, but marginally in the chronic haloperidol group before CBD. There was increased antioxidant activity in the sub-chronic group compared to the chronic group.

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Cannabinoids in Neuroinflammation, Oxidative Stress and Neuro Excitotoxicity

Cited by 5 publications

References 68 publications

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?

High Concentrations of Cannabidiol Induce Neurotoxicity in Neurosphere Culture System

The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration

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