Cantilever Sensors

Peiner, Erwin; Wasisto, Hutomo Suryo

doi:10.3390/s19092043

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…In CFM (Clear and Nealey 1999;Takano et al, 1999;Okabe et al, 2000;Fiorini et al, 2001;Kreller et al, 2002;Brewer and Leggett 2004;Gourianova et al, 2005;Cameron et al, 2006;Dague et al, 2007;Dufrene 2008;Foster et al, 2009;Sirghi et al, 2009;Barattin and Voyer 2011;Teobaldi et al, 2011;Alsteens et al, 2012;Picas et al, 2012;Beaussart et al, 2014;Hibino and Nakano-Nishida 2014), cantilever tips are chemically functionalized with particular functional groups for performing specific functions in a system. CFM relies on two approaches: microcantilever-based biosensors (MC-B) (Subramanian and Catchmark 2007;Lang and Gerber 2008;Gruber et al, 2011;Johnson and Mutharasan 2012;Peiner and Wasisto 2019;Bennett et al, 2020;Lee and Lee 2020;Mamou et al, 2021) and nanomechanical cantilever sensors (NCS) to achieve these goals of characterizing and understanding the system at single-molecule level with high reproducibility and repeatability. The microcantilever-based biosensing utilizes the specific binding of biomolecules for analytical sensing.…”

Section: Afm As Biosensormentioning

confidence: 99%

“…Major controllers of sensitivity (produced by irreversible interactions) are the degree of uniformity of the sensor surface coating and external stimuli affecting the molecular reorganization. Few studies where NCS (Fagan et al, 2000;Mertens et al, 2019;Peiner and Wasisto 2019) was used efficiently to achieve this goal are mentioned here. For example, adsorption of gas can cause bending and deflection of functionalized cantilever.…”

Section: Afm As Biosensormentioning

confidence: 99%

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Biosensing, Characterization of Biosensors, and Improved Drug Delivery Approaches Using Atomic Force Microscopy: A Review

Sarkar

2022

Front. Nanotechnol.

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Since its invention, atomic force microscopy (AFM) has come forth as a powerful member of the “scanning probe microscopy” (SPM) family and an unparallel platform for high-resolution imaging and characterization for inorganic and organic samples, especially biomolecules, biosensors, proteins, DNA, and live cells. AFM characterizes any sample by measuring interaction force between the AFM cantilever tip (the probe) and the sample surface, and it is advantageous over other SPM and electron micron microscopy techniques as it can visualize and characterize samples in liquid, ambient air, and vacuum. Therefore, it permits visualization of three-dimensional surface profiles of biological specimens in the near-physiological environment without sacrificing their native structures and functions and without using laborious sample preparation protocols such as freeze-drying, staining, metal coating, staining, or labeling. Biosensors are devices comprising a biological or biologically extracted material (assimilated in a physicochemical transducer) that are utilized to yield electronic signal proportional to the specific analyte concentration. These devices utilize particular biochemical reactions moderated by isolated tissues, enzymes, organelles, and immune system for detecting chemical compounds via thermal, optical, or electrical signals. Other than performing high-resolution imaging and nanomechanical characterization (e.g., determining Young’s modulus, adhesion, and deformation) of biosensors, AFM cantilever (with a ligand functionalized tip) can be transformed into a biosensor (microcantilever-based biosensors) to probe interactions with a particular receptors of choice on live cells at a single-molecule level (using AFM-based single-molecule force spectroscopy techniques) and determine interaction forces and binding kinetics of ligand receptor interactions. Targeted drug delivery systems or vehicles composed of nanoparticles are crucial in novel therapeutics. These systems leverage the idea of targeted delivery of the drug to the desired locations to reduce side effects. AFM is becoming an extremely useful tool in figuring out the topographical and nanomechanical properties of these nanoparticles and other drug delivery carriers. AFM also helps determine binding probabilities and interaction forces of these drug delivery carriers with the targeted receptors and choose the better agent for drug delivery vehicle by introducing competitive binding. In this review, we summarize contributions made by us and other researchers so far that showcase AFM as biosensors, to characterize other sensors, to improve drug delivery approaches, and to discuss future possibilities.

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Section: Afm As Biosensormentioning

confidence: 99%

Section: Afm As Biosensormentioning

confidence: 99%

Biosensing, Characterization of Biosensors, and Improved Drug Delivery Approaches Using Atomic Force Microscopy: A Review

Sarkar

2022

Front. Nanotechnol.

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“…Биохимические анализаторы состава газообразных и жидких смесей, основанные на технологиях MEMS и NEMS, привлекают внимание многих исследователей уже около двух десятков лет. Заметное место в ряду таких измерительных средств занимают сенсоры на основе микрокантилеверов (МК) [1][2][3][4][5][6][7][8][9][10][11][12]. Информационным сигналом таких сенсоров является резонансная частота собственных колебаний МК, которая весьма просто преобразуется в цифровой сигнал.…”

Section: Introductionunclassified

Моделирование Колебаний Нанопористых Микрокантилеверов Из Анодного Оксида Алюминия Для Биохимических Сенсоров

Симонов¹,

Matison²,

Boitsova³

et al. 2020

Матем. моделирование

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Описаны результаты исследования колебаний микрокантилеверов (МК), выполненных из нанопористого анодного оксида алюминия и составляющих основу биохимических сенсоров. Конечно-элементное моделирование колебаний МК выявило источники появления в частотном спектре резонансов, не соответствующих колебаниям кантилевера и осложняющих разработку сенсоров. Впервые показано, что такими источниками являются резонансы колебаний основания МК на упругом слое компаунда, используемого для присоединения основания к подложке. Получены приблизительные соотношения между параметрами МК, основания и компаундного слоя, обеспечивающие присутствие в спектре только рабочих мод колебаний МК. Для обеспечения чистого спектра необходимо соблюдение одного из двух условий или их сочетания: достаточно жесткого крепления МК к подложке и достаточно малых размеров основания. Обеспечение чистого спектра достигается безотносительно к жесткости крепления МК, если длина основания не превышает: для 3-й, 4-й и 5-й гармоник рабочей моды МК соответственно 0.6, 0.43 и 0.33 длины МК.

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Role of Modern Innovative Techniques for Assessing and Monitoring Heavy Metal and Pesticide Pollution in Different Environments

Tonelli

2020

Bioremediation and Biotechnology, Vol 2

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Cantilever Sensors

Abstract: A cantilever is considered the most basic mechanical spring-mass system and has enormous application potential for sensors [...]

Cited by 4 publications

References 7 publications

Biosensing, Characterization of Biosensors, and Improved Drug Delivery Approaches Using Atomic Force Microscopy: A Review

Biosensing, Characterization of Biosensors, and Improved Drug Delivery Approaches Using Atomic Force Microscopy: A Review

Моделирование Колебаний Нанопористых Микрокантилеверов Из Анодного Оксида Алюминия Для Биохимических Сенсоров

Role of Modern Innovative Techniques for Assessing and Monitoring Heavy Metal and Pesticide Pollution in Different Environments

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