CaP coated mesoporous polydopamine nanoparticles with responsive membrane permeation ability for combined photothermal and siRNA therapy

Wang, Zhenqiang; Wang, Liucan; Prabhakar, Neeraj; Xing, Yuxin; Rosenholm, Jessica M.; Zhang, Jixi; Cai, Kaiyong

doi:10.1016/j.actbio.2019.01.002

Cited by 75 publications

(56 citation statements)

References 48 publications

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“…Thus, the Cu II -doped PDA nanoparticles with long blood circulation and stability would be potential for MR imaging-guided PTT and chemotherapy of cancer. Gene therapy has been reported by loading siRNA onto the surface of tertiary amine-modified mesoporous PDA nanoparticles via electrostatic interactions 43. An out layer coating of calcium phosphate (CaP) was then formed via PDA-induced biomineralization and acted as the protecting layer to prevent the premature release of the loaded siRNA.…”

Section: Mussel-inspired Pda Particlesmentioning

confidence: 99%

“…PDA particles showed high biocompatibility, physiological stability, and photostability in both in vitro and in vivo tests 34, 37, 38. In addition, PDA particles could be incorporated with a variety of cargos, including anti-cancer drugs for chemotherapy, metal ions as imaging agents, photosensitizers for photodynamic therapy (PDT), siRNA for gene therapy, as well as different functional nanoparticles as imaging or therapeutic agents 39-43. Thereby, the PDA-based particle systems have been demonstrated for a series of imaging-guided combination therapy of cancer 32, 41, 44, 45.…”

Section: Introductionmentioning

confidence: 99%

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Polyphenol-Based Particles for Theranostics

et al. 2019

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Polyphenols, due to their high biocompatibility and wide occurrence in nature, have attracted increasing attention in the engineering of functional materials ranging from films, particles, to bulk hydrogels. Colloidal particles, such as nanogels, hollow capsules, mesoporous particles and core-shell structures, have been fabricated from polyphenols or their derivatives with a series of polymeric or biomolecular compounds through various covalent and non-covalent interactions. These particles can be designed with specific properties or functionalities, including multi-responsiveness, radical scavenging capabilities, and targeting abilities. Moreover, a range of cargos (e.g., imaging agents, anticancer drugs, therapeutic peptides or proteins, and nucleic acid fragments) can be incorporated into these particles. These cargo-loaded carriers have shown their advantages in the diagnosis and treatment of diseases, especially of cancer. In this review, we summarize the assembly of polyphenol-based particles, including polydopamine (PDA) particles, metal-phenolic network (MPN)-based particles, and polymer-phenol particles, and their potential biomedical applications in various diagnostic and therapeutic applications.

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Section: Mussel-inspired Pda Particlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyphenol-Based Particles for Theranostics

et al. 2019

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“…Apart from these, a wide variety of PDA‐based nanomaterials have shown remarkable performance in PTT. [ 64–71 ]…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Polydopamine‐Incorporated Nanoformulations for Biomedical Applications

Zheng

Ding

Gao

2020

Macromolecular Bioscience

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Polydopamine (PDA), a pigment in natural melanin, has attracted considerable attention because of its excellent optical properties, extraordinary adhesion, and good biocompatibility, which make it a promising material for application in energy, environmental, and biomedical fields. In this review, PDA‐incorporated nanoformulations are focused for biomedical applications such as drug delivery, bioimaging, and tumor therapy. First, the recent advances in PDA‐incorporated nanoformulations for drug delivery are discussed. Further, their application in boimaging, such as fluorescence imaging, photothermal imaging, and photoacoustic imaging, is reviewed. Next, their therapeutic applications, including chemotherapy, photodynamic therapy, photothermal therapy, and synergistic therapy are discussed. Finally, other biomedical applications of PDA‐incorporated nanoformulations such as biosensing and clinical diagnosis are briefly presented. Finally, the biomedical applications of PDA‐incorporated nanoformulations along with their prospects are summarized.

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“…The mesoporous structures (average diameter ≈90 nm with slit‐like pores of ≈5.0 nm) could be obtained because of the combined effects of π−π stacking interactions between PDA structures and the π electron‐rich TMB molecules. The as‐prepared MPDA NPs were made applicable for combined gene and PT therapies . The MPDA NPs were firstly functionalized with small interfering RNA (siRNA) via tertiary amine modification, followed by biomineralization by HAP to prevent the burst release of gene delivery.…”

Section: Colloidal Pda Particlesmentioning

confidence: 99%

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

Tran

Batul

Bhave

et al. 2019

Biotechnology Journal

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Since the first time mussel‐inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA‐based materials for therapeutic purposes. A description of the diverse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.

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CaP coated mesoporous polydopamine nanoparticles with responsive membrane permeation ability for combined photothermal and siRNA therapy

Cited by 75 publications

References 48 publications

Polyphenol-Based Particles for Theranostics

Polyphenol-Based Particles for Theranostics

Polydopamine‐Incorporated Nanoformulations for Biomedical Applications

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

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