Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

Gomes, Ana Thereza; Cunha, Liliane M.; Bastos, Claudilson; Medrado, Bruno Frederico; Assis, Bárbara C.A.; Andrade, Zilton de Araújo

doi:10.1590/s0074-02762006000800012

Cited by 15 publications

(17 citation statements)

References 11 publications

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“…Also, no modification was seen when focal parasitic lesions were compared between the hepatectomized rats and their controls. In fact, these focal parasitic lesions run an independent course with regard to systematized septal fibrosis in rat capillariasis, as a recent investigation has revealed 4 .…”

Section: Discussionmentioning

confidence: 96%

Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats

Santos

Onofre-Nunes

Andrade

2007

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 96%

Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats

Santos

Onofre-Nunes

Andrade

2007

Rev. Soc. Bras. Med. Trop.

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“…Con respecto a los hallazgos histopatológicos y la asociación con la presencia de infección de C. hepática, el esquema de clasificación usado en este estudio, que representa la secuencia lógica de los cambios histopatológicos asociados con la evolución de la enfermedad, incluyendo el desarrollo y la muerte de los parásitos y sus huevos, la resolución de la inflamación y remoción de los parásitos (14,30), permitió determinar que las lesiones de la categoría intermedia fueron las más frecuentes, predominando un patrón de distribución focal, seguido del multifocal y solo en tres de las muestras se encontró un patrón difuso.…”

Section: Discussionunclassified

Rattus norvegicus como indicador de la circulación de Capillaria hepatica y Taenia taeniaeformis en la Plaza Minorista de Medellín, Colombia

et al. 2012

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participaron en la recolección de la información, tanto de roedores como registros de histopatología. Diego Aranzazu hizo el análisis de los resultados histopatológicos y escritura del artículo. Juan D. Rodas y Piedad Agudelo-Flórez fueron los investigadores principales del proyecto inicial, realizaron el análisis de resultados, y la edición y corrección de estilo del artículo. ARTÍCULO ORIGINAL Biomédica 2012;32:510-8 doi: http://dx.doi.org/10.7705/biomedica.v32i4.442 Rattus norvegicus como indicador de la circulación de Capillaria hepatica y Taenia taeniaeformis en la Plaza Minorista de Medellín, Colombia Rattus norvegicus as an indicator of circulation of Capillaria hepatica and Taenia taeniaeformis on a groceries trade center of Medellín, ColombiaIntroduction. Rattus norvegicus, the Norway rat, plays a pivotal role in the maintenance and spread of several zoonotic bacterial, viral and parasitic pathogens of public health interest. The presence of helminthic infections near susceptible human populations can, under appropriate environmental conditions, become a risk factor for their transmission.Objective. Frequencies of infection were reported for Capillaria hepatica and larval forms of Taenia taeniaeformis in wild rats (R. norvegicus) captured in an urban area. Materials and methods. Two hundred and fifty-four adult specimens of R. norvegicus were collected in an urban zone of Medellín, Colombia. The livers of 54 specimens that showed macroscopic hepatic lesions during necropsy were examined by conventional histopathology.Results. The frequency of infestation with C. hepatica was 20.1% (51/254). Six livers (2.4%) were also positive for larvae of T. taeniaeformis. Livers infested with C. hepatica exhibited adult or juvenile parasites and oval eggs with bipolar opercula, and were associated with mild to moderate multifocal granulomatous hepatitis with leucocyte infiltrate. Granulomatous lesions and calcified residual fibroses

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“…C hepatica infection results in multifocal granulomatous inflammation directly associated with the presence of live, dying, and dead worms and their eggs, followed by septal fibrosis. 2,12,25,30 T taeniaformis is the adult tapeworm that lives in the small intestine of carnivores such as cats, and rodents are the intermediate hosts. 20 The eggs of T taeniaformis develop into larvae, which form cysts in the liver parenchyma of rodents, inducing vigorous fibroplasia and progressive inflammation.…”

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Prevalence of Hepatic Parasites in Korean Wild Rats (Rattus norvegicus) and Their Association With Pulmonary Arteriolar Medial Hypertrophy

Kim

et al. 2009

Vet Pathol

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C hepatica, an important zoonotic parasite, and C fasciolaris are common parasites in rodents. In rodent livers, C hepatica causes sequential morphologic changes that are designated as early, intermediate, or late phase, and C fasciolaris forms cysts surrounded by fibroplasia and granulomatous inflammation. The present study describes the prevalence of these parasites and associated liver and lung lesions in wild rats (Rattus norvegicus) living around pig farms in South Korea. Selected parenchymal organs, including liver and lung, of 89 wild rats were examined. Of 89 rats, 28 (31.5%) were infected with either C hepatica or C fasciolaris or with both parasites. Severe medial hypertrophy of small arterioles was observed in the lungs of 11 of the 28 parasite-infected rats (P < .01). The pulmonary arteriolar hypertrophy in the rats infected with C hepatica was strongly associated with early and/or intermediate phases (88.8%) of morphologic change in the livers (P < .01). As such, this report is the first to suggest a significant association between parasite-induced hepatitis and pulmonary arteriolar hypertrophy in rodents. Further studies are warranted for the use of C hepatica-infected rats as an animal model to explore the underlying mechanisms of portopulmonary hypertension in humans.

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Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

Cited by 15 publications

References 11 publications

Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats

Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats

Rattus norvegicus como indicador de la circulación de Capillaria hepatica y Taenia taeniaeformis en la Plaza Minorista de Medellín, Colombia

Prevalence of Hepatic Parasites in Korean Wild Rats (Rattus norvegicus) and Their Association With Pulmonary Arteriolar Medial Hypertrophy

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