Capillary Abnormalities in Polyvinyl Chloride Production Workers

Maricq, Hildegard R.

doi:10.1001/jama.1976.03270130030022

Cited by 37 publications

(3 citation statements)

References 12 publications

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“…Recently, Hirano et al suggested that glutathione conjugates of arsenic are toxic in rat heart micro-vessel endothelial cells (Hirano et al 2004). In many studies, endothelial damage has probably occurred because several studies have documented vascular injury and microvascular lesions in CVM disease (Suciu et al 1975;Fallappa et al 1982;Maricq et al 1976;Freudiger et al 1988). However, to date, no experimental endothelial toxicity of any VCM metabolites, whether conjugated or not, has been documented.…”

Section: Discussionmentioning

confidence: 99%

“…VCM exposure is toxic for the vascular endothelium, as shown by angiographic studies of hand arteries and by capillaroscopic examinations (Falappa et al 1982;Maricq et al 1976). VCM exposure can induce Raynaud's phenomenon (RP), characterized by episodic digital vasospasm provoked mainly by cold (Wilson et al 1967).…”

Section: Introductionmentioning

confidence: 99%

“…The first cases of RP were recorded in workers called autoclave cleaners, who were lowered into reactor vessels to clean polymer residues stuck to the walls manually; these were usually the highest VCMexposed jobs in PVC-polymerisation plants (Wilson 1967;Harris and Adams 1967;Veltman et al 1975;Suciu et al 1975;Maricq et al 1976;Markowitz et al 1977). However, other cases have since been described in VCM-exposed workers who had never been employed for this type of job or who had worked in less exposed workplaces (Black et al 1986;Walker 1976;Freudiger et al 1988).…”

Section: Introductionmentioning

confidence: 99%

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Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud’s phenomenon in French vinyl chloride monomer-exposed workers

et al. 2006

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Occupational vinyl chloride monomer (VCM) exposure can induce Raynaud's phenomenon (RP). However, not all VCM workers developed RP, which suggests an underlying genetic susceptibility. Genetic polymorphisms of glutathione S-transferases (GSTs), involved in VCM metabolism, have been shown to influence certain VCM-related health effects. We have conducted a case-control study of 58 subjects with RP along with 247 subjects without RP, from a population of 305 French workers exposed or formerly exposed to VCM, to assess any association between GST M1 and GST T1 gene polymorphisms, either separately or in combination, and the presence of RP. None of the GST M1 or GST T1 genotypes were significantly associated with the presence of RP among studied VCM workers. A combination of positive genotypes for both GST M1 and GST T1 was significantly associated with RP presence, compared to the other combinations of genotypes (OR=2.1, 95% CI=1.1-3.8). OR adjusted for age, smoking status, alcohol consumption and history of treated hypertension did not reach significance (OR=2.0, 95% CI=0.9-5.2). None of the GST M1 and GST T1 genotypes seem to contribute separately to the presence of RP, suggesting that they are not, when taken alone, a major determinant of interindividual variability for VCMinduced PR. However, the combination of both positive GST M1 and GST T1 genotypes appears to contribute slightly to susceptibility to RP in VCM-exposed subjects. Nevertheless, our study-the first to examine the role of a genetic component in the occurrence of RP secondary to occupational exposure to a chemical-corroborates the previous considerations that interaction between the genetic constitution and environmental factors is of importance in determining the health-adverse effects of VCM exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud’s phenomenon in French vinyl chloride monomer-exposed workers

et al. 2006

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Clinical spectrum of connective tissue disease after cosmetic surgery

Kumagai

Shiokawa

Medsger

et al. 1984

Arthritis & Rheumatism

241

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Connective tissue disease has been reported to occur following cosmetic surgery with injection of the foreign substances paraffin and silicone (human adjuvant disease). The clinical findings in 18 such patients and a review of 28 additional cases from the Japanese literature are presented. The patients were classified into 2 major groups: group I consisted of 24 patients with definite connective tissue disease—12 with scleroderma, including 8 with progressive systemic sclerosis (PSS), 6 with rheumatoid arthritis, 5 with systemic lupus erythematosus, and 1 with polymyositis; group II consisted of 22 patients with human adjuvant disease with some symptoms, signs, and laboratory abnormalities suggestive, but not diagnostic of a connective tissue disease. The occurrence of PSS is approximately three‐fold greater than expected for all women believed to have undergone such surgery, and PSS developed primarily in individuals injected with paraffin. Prolonged exposure to the injected substance may play a role in the induction of these immunologic disorders.

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Systemic sclerosis associated with cutaneous exposure to solvent: Case report and review of the literature

Brasington

Thorpe-Swenson

1991

Arthritis & Rheumatism

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Sclerodermatous skin changes and systemic sclerosis have been reported to occur as a result of contact with several different organic solvents. We describe a 41‐year‐old man who developed systemic sclerosis after working for 15 years in a foundry, where he had extensive cutaneous contact with multiple organic solvents (trichloroethane, xylene, trimethylbenzene, and naphthalene). Cutaneous exposure to organic solvents may be a factor in the etiology of some cases of systemic sclerosis.

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Capillary Abnormalities in Polyvinyl Chloride Production Workers

Cited by 37 publications

References 12 publications

Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud’s phenomenon in French vinyl chloride monomer-exposed workers

Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud’s phenomenon in French vinyl chloride monomer-exposed workers

Clinical spectrum of connective tissue disease after cosmetic surgery

Systemic sclerosis associated with cutaneous exposure to solvent: Case report and review of the literature

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