Capillary Hemangioma of the Lids and Orbit: An Analysis of The Clinical Features and Therapeutic Results in 101 Cases

Haik, Barrett G.; Jakobiec, Frederick A.; Ellsworth, Robert M.; Jones, Isaac H.

doi:10.1016/s0161-6420(79)35452-5

Cited by 183 publications

(105 citation statements)

References 16 publications

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“…children with untreated periocular IHs, usually as a result of visual deprivation or refractive errors. [294][295][296] Deprivation amblyopia occurs when a bulky IH, usually in the upper eyelid, completely obstructs visual input into the involved eye. The lack of input causes a maldevelopment of visual pathways and may result in irreversible loss of vision.…”

Section: Highlights Of This Sectionmentioning

confidence: 99%

“…Astigmatism is the production of a blurred image on the retina due to altered curvature of the cornea and occurs in 20% to 46% of patients with periocular IHs. 298 IHs causing this disorder usually involve the upper lid 294 (Fig 14) but may occur in the lower lid as well. The astigmatism can be reversed with early intervention, preferably before 9 months of age.…”

Section: Highlights Of This Sectionmentioning

confidence: 99%

“…294 Strabismus may result from deprivation amblyopia, mechanical obstruction of extraocular muscle movements, or direct extraocular muscle invasion. Medial rectus involvement is most common and most obvious, producing esotropia.…”

Section: Highlights Of This Sectionmentioning

confidence: 99%

“…Optic neuropathy may also result from compression or stretching of the optic nerve. 294 Patients with PHACE syndrome may present with a unique set of ophthalmologic abnormalities, including increased retinal vascularity, microphthalmia, optic nerve hypoplasia, exophthalmos, choroidal hemangiomas, strabismus, colobomas, cataracts, and glaucoma. Twenty percent of affected patients will have at least 1 of these findings, often on the side contralateral to the IH.…”

Section: Highlights Of This Sectionmentioning

confidence: 99%

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Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

217

290

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Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its purpose is to update the pediatric community regarding recent discoveries in IH pathogenesis, treatment, and clinical associations and to provide a basis for clinical decision-making in the management of IH.

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Section: Highlights Of This Sectionmentioning

confidence: 99%

Section: Highlights Of This Sectionmentioning

confidence: 99%

Section: Highlights Of This Sectionmentioning

confidence: 99%

Section: Highlights Of This Sectionmentioning

confidence: 99%

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Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

217

290

View full text Add to dashboard Cite

show abstract

“…There is a slight female predilection, with a female-to-male ratio of 3:2 (19,25). The tumor may be present at birth as a reddish macule, but in most cases the tumor becomes apparent within the first few weeks to months of life.…”

Section: Infantile Hemangiomamentioning

confidence: 99%

Pediatric Orbit Tumors and Tumorlike Lesions: Nonosseous Lesions of the Extraocular Orbit

Chung¹,

Smirniotopoulos²,

Specht³

et al. 2007

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Oral Corticosteroid Use Is Effective for Cutaneous Hemangiomas

Bennett¹,

Fleischer²,

Chamlin³

et al. 2001

Arch Dermatol

324

201

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To determine the efficacy of systemic corticosteroid therapy in treating enlarging, problematic cutaneous hemangiomas and to assess the relationship of dose to response and adverse effects. Design: A quantitative systematic literature review was performed and inclusion and exclusion criteria were applied. Setting: Patients were treated in primary care, referral centers, and institutional practices. Most patients were ambulatory, although some required hospitalization. Patients: Inclusion criteria were original case series with a minimum of 5 patients with enlarging, problematic cutaneous hemangiomas treated with systemic corticosteroids. Exclusion criteria were being older than 2 years, receiving simultaneous other treatments, being lost to follow-up, or having insufficient information. Twenty-four original case series met inclusion criteria; 10 case series remained (184 patients) after exclusion criteria were applied. Intervention: Patients were given a mean prednisone equivalent daily dose of 2.9 mg/kg (95% confidence interval [CI], 2.7-3.1 mg/kg) for a mean of 1.8 months (95% CI, 1.5-2.2 months). Main Outcome Measures: Response and rebound rates and dose-response and adverse effects-response relationships in responders vs nonresponders. Results: Response was 84% (95% CI, 78%-89%; range, 60%-100%) and rebound was 36% (95% CI, 29%-44%; range, 0%-65%). A significant difference was found between the mean dose administered to responders vs nonresponders (PϽ.001). No significant difference was observed as to the occurrence of adverse effects (P=.3). Conclusion: Systemic corticosteroid treatment seems to be effective for problematic cutaneous hemangiomas of infancy.

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Capillary Hemangioma of the Lids and Orbit: An Analysis of The Clinical Features and Therapeutic Results in 101 Cases

Cited by 183 publications

References 16 publications

Diagnosis and Management of Infantile Hemangioma

Diagnosis and Management of Infantile Hemangioma

Pediatric Orbit Tumors and Tumorlike Lesions: Nonosseous Lesions of the Extraocular Orbit

Oral Corticosteroid Use Is Effective for Cutaneous Hemangiomas

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