Capturing Amplitude Changes of Low-Frequency Fluctuations in Functional Magnetic Resonance Imaging Signal: A Pilot Acupuncture Study on <i>NeiGuan</i> (PC6)

Zhang, Gang; Yin, Hao; Zhou, You-long; Huang, Han; Yun-xia, WU; Xing, Wei; Xu, Huihui; Zuo, Xi‐Nian

doi:10.1089/acm.2010.0205

Cited by 22 publications

(18 citation statements)

References 49 publications

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“…At present, resting-state functional magnetic resonance imaging (Rs-fMRI) technology has been gradually applied in the acupuncture research field. In order to avoid the “stress” effect of acupuncture in the course of study, Rs-fMRI scan was conducted after withdrawing the needle, instead of during needle-retaining [8, 16, 17], which makes up for the inadequacies of Block Design and can actually simulate the acupuncture treatment process.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension: An Rs‐fMRI Study and Curative Effect Evidence

Wang

Zheng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The study attempted to explore that the synergistic effect of acupoints combination is not a simple superposition of single acupoint's effect by comparing and analyzing the changes of blood pressure (BP), SF-36, and brain regions after acupuncture treatment. 47 patients were randomly divided into LR3+KI3 group, LR3 group, and KI3 group. Subjects received Rs-fMRI scan, BP measurement, and SF-36 questionnaires before and after treatment and short-term acupuncture treatment. After treatment, there were no significant differences in BP and SF-36 among 3 groups, compared to the case before treatment, SBP of 3 groups decreased, and DBP significantly decreased while vitality and mental health significantly increased in LR3+KI3 group. Both number and scopes of changes of brain regions in LR3+KI3 group were the largest, which mainly included BAs 3, 4, 8, 19, 21, 24, 32, 44, and 45. In conclusion, acupuncture at LR3+KI3 may auxiliarily reduce BP and improve the vitality and mental health of patients, and the changes of brain regions were related to somatesthesia, movement, vision, audition, emotion and mood, language, memory, etc. BAs 4, 9, 10, 24, 31, 32, and 46 may be the targeting brain areas of acupuncture in assisting hypotension. It is suggested that acupoints combination of LR3+KI3 maybe generates a synergistic effect, and it is not simple sum of single acupoint effect.

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Section: Introductionmentioning

confidence: 99%

Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension: An Rs‐fMRI Study and Curative Effect Evidence

Wang

Zheng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…Most of the studies were conducted in China (80 studies) [10, 11, 13, 14, 16, 18–24, 26, 27, 29–31, 33–36, 43–46, 48, 51, 53, 54, 56, 58–66, 68–70, 72–75, 77, 78, 83, 84, 86, 87, 89, 90, 93, 95, 97, 99–101, 104, 111, 113, 115, 123, 137, 138, 142, 144–147, 154, 159, 161–166] and in USA (40 studies) [15, 28, 37, 38, 42, 57, 70, 71, 76, 80, 88, 91, 94, 96, 105–107, 118–120, 124–127, 129–131, 133–136, 140, 141, 148, 151, 152, 155, 156, 158, 174]. The investigators in Korea (16 studies) [7, 47, 49, 52, 55, 82, 85, 98, 102, …”

Section: Resultsmentioning

confidence: 99%

“…The investigators in Korea (16 studies) [7, 47, 49, 52, 55, 82, 85, 98, 102, 109, 112, 114, 116, 117, 122, 153], Taiwan (6 studies) [79, 110, 128, 170, 171, 175], Austria (6 studies) [132, 139, 150, 160, 168, 176], Germany (5 studies) [32, 50, 157, 167, 169], Australia (4 studies) [40, 41, 92, 121], Japan (4 studies) [39, 108, 149, 173], UK (4 studies) [17, 67, 81, 103], Italy (2 studies) [25, 172], and Denmark (1 study) [143] also published articles on acupuncture-neuroimaging (Figure 1). 60 studies [16, 19, 23, 25, 26, 37, 38, 42, 45, 46, 55, 56, 60, 62, 65, 67, 70–72, 75, 78, 81, 87, 88, 90, 93, 97, 100, 101, 104, 106, 107, 110, 111, 113–115, 117–121, 123, 126–129, 132, 134…”

Section: Resultsmentioning

confidence: 99%

“…Taking studies on the stroke for instance, the maximal age range of the stroke patients was 52, while the minimal age range was 7. Furthermore, 66 studies [11, 13–15, 20–22, 25, 28, 29, 31–33, 36–38, 43, 49, 50, 55, 56, 58, 61, 64, 66–68, 75, 78, 79, 83, 86, 88, 90, 91, 93, 95, 96, 99, 100, 104, 106, 110, 111, 113, 115, 118, 119, 123, 126–128, 130, 136, 138, 140, 146, 147, 154–156, 159, 161, 163, 169, 176] described the average age of participants. Three studies [94, 163, 170] did not mention the age of participants.…”

Section: Resultsmentioning

confidence: 99%

“…136 [10–24, 26, 28, 30–36, 39–56, 58, 59, 61–80, 83–87, 89–93, 95, 96, 98–100, 103–107, 109–111, 113–115, 117–131, 133, 135–138, 140–142, 144, 146–149, 151–157, 159, 162–164, 166, 168, 169, 171, 173–175] studies asked for the right-hand participants in inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

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The Status of the Quality Control in Acupuncture‐Neuroimaging Studies

Qiu

Jing

Sun

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Using neuroimaging techniques to explore the central mechanism of acupuncture gains increasing attention, but the quality control of acupuncture-neuroimaging study remains to be improved. We searched the PubMed Database during 1995 to 2014. The original English articles with neuroimaging scan performed on human beings were included. The data involved quality control including the author, sample size, characteristics of the participant, neuroimaging technology, and acupuncture intervention were extracted and analyzed. The rigorous inclusion and exclusion criteria are important guaranty for the participants' homogeneity. The standard operation process of acupuncture and the stricter requirement for acupuncturist play significant role in quality control. More attention should be paid to the quality control in future studies to improve the reproducibility and reliability of the acupuncture-neuroimaging studies.

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Characterization of thalamo-cortical association using amplitude and connectivity of functional MRI in mild traumatic brain injury

Zhou

Lui

Zuo

et al. 2013

J. Magn. Reson. Imaging

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Purpose To examine thalamic and cortical injuries using fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity MRI (fcMRI) based on resting state (RS) and task-related fMRI in patients with mild traumatic brain injury (MTBI). Materials and Methods Twenty-seven patients and 27 age-matched controls were recruited. 3T fMRI at RS and finger tapping task were used to assess fALFF and fcMRI patterns. fALFF was computed with filtering (0.01-0.08Hz) and scaling after preprocessing. fcMRI was performed using a standard seed-based correlation method, and delayed fcMRI (coherence) in frequency domain were also performed between thalamus and cortex. Results In comparison with controls, MTBI patients exhibited significantly decreased fALFF in the thalamus (and frontal/temporal sub segments) and cortical frontal and temporal lobes; as well as decreased thalamo-thalamo and thalamo-frontal/thalamo-temporal fcMRI at rest based on RS-fMRI (corrected P<0.05). This thalamic and cortical disruption also existed at task-related condition in patients. Conclusion The decreased fALFF (i.e. lower neuronal activity) in the thalamus and its segments provides additional evidence of thalamic injury in patients with MTBI. Our findings of fALFF and fcMRI changes during motor task and resting state may offer insights into the underlying cause and primary location of disrupted thalamo-cortical networks after MTBI.

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Capturing Amplitude Changes of Low-Frequency Fluctuations in Functional Magnetic Resonance Imaging Signal: A Pilot Acupuncture Study on NeiGuan (PC6)

Cited by 22 publications

References 49 publications

Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension: An Rs‐fMRI Study and Curative Effect Evidence

Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension: An Rs‐fMRI Study and Curative Effect Evidence

The Status of the Quality Control in Acupuncture‐Neuroimaging Studies

Characterization of thalamo-cortical association using amplitude and connectivity of functional MRI in mild traumatic brain injury

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