CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury

Li, Ting; Pei, Jing; Yang, Lingling; Wan, Yujie; Du, Xingjie; Wei, Jun; Zhou, Meiling; Liu, Zhongbing; Zhong, Zhaohui

doi:10.1016/j.nano.2022.102526

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…Li et al designed a nanoparticle containing the polypeptide CAQK (CAQK-MET-NPs) for targeted delivery of metformin. While exerting anti-inflammatory, antioxidant, and neuroprotective effects, it overcomes the disadvantages of poor water solubility and low bioavailability of drugs and ultimately promotes spinal cord repair and motor function improvement [ 229 ].…”

Section: Treatment Strategies For Scimentioning

confidence: 99%

[Retracted] Recent Advances in Cell and Functional Biomaterial Treatment for Spinal Cord Injury

Liu

Zhu

Zhang

et al. 2022

BioMed Research International

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Spinal cord injury (SCI) is a devastating central nervous system disease caused by accidental events, resulting in loss of sensory and motor function. Considering the multiple effects of primary and secondary injuries after spinal cord injury, including oxidative stress, tissue apoptosis, inflammatory response, and neuronal autophagy, it is crucial to understand the underlying pathophysiological mechanisms, local microenvironment changes, and neural tissue functional recovery for preparing novel treatment strategies. Treatment based on cell transplantation has become the forefront of spinal cord injury therapy. The transplanted cells provide physical and nutritional support for the damaged tissue. At the same time, the implantation of biomaterials with specific biological functions at the site of the SCI has also been proved to improve the local inhibitory microenvironment and promote axonal regeneration, etc. The combined transplantation of cells and functional biomaterials for SCI treatment can result in greater neuroprotective and regenerative effects by regulating cell differentiation, enhancing cell survival, and providing physical and directional support for axon regeneration and neural circuit remodeling. This article reviews the pathophysiology of the spinal cord, changes in the microenvironment after injury, and the mechanisms and strategies for spinal cord regeneration and repair. The article will focus on summarizing and discussing the latest intervention models based on cell and functional biomaterial transplantation and the latest progress in combinational therapies in SCI repair. Finally, we propose the future prospects and challenges of current treatment regimens for SCI repair, to provide references for scientists and clinicians to seek better SCI repair strategies in the future.

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Section: Treatment Strategies For Scimentioning

confidence: 99%

[Retracted] Recent Advances in Cell and Functional Biomaterial Treatment for Spinal Cord Injury

Liu

Zhu

Zhang

et al. 2022

BioMed Research International

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“…The β-LG/DSF was prepared using the reverse solvent precipitation method. The CAQK peptide selectively binds to a proteoglycan complex that is up-regulated during brain injuries and coupled with drug molecules and nanoparticles to increase their accumulation at the injury site ( 20 , 21 ). Thus, the CAQK peptide was further modified into β-LG/DSF to form C-β-LG/DSF and increase the DSF concentration at the injury site.…”

Section: Resultsmentioning

confidence: 99%

Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury

Zhang,

Huang,

Hang

et al. 2024

Sci. Adv.

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Posttraumatic neuroinflammation is a key driver of secondary injury after traumatic brain injury (TBI). Pyroptosis, a proinflammatory form of programmed cell death, considerably activates strong neuroinflammation and amplifies the inflammatory response by releasing inflammatory contents. Therefore, treatments targeting pyroptosis may have beneficial effects on the treatment of secondary brain damage after TBI. Here, a cysteine-alanine-glutamine-lysine peptide–modified β-lactoglobulin (β-LG) nanoparticle was constructed to deliver disulfiram (DSF), C-β-LG/DSF, to inhibit pyroptosis and decrease neuroinflammation, thereby preventing TBI-induced secondary injury. In the post-TBI mice model, C-β-LG/DSF selectively targets the injured brain, increases DSF accumulation, and extends the time of the systemic circulation of DSF. C-β-LG/DSF can alleviate brain edema and inflammatory response, inhibit secondary brain injury, promote learning, and improve memory recovery in mice after trauma. Therefore, this study likely provided a potential approach for reducing the secondary spread of TBI.

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“…Li et al. [ 105 ] applied its properties to packaging metformin and self-assembled it into NPs, the outer layer of which was modified by crosslinking CAQK with NHS-PEG 5000 -MAL. The CAQK peptides selectively bound to chondroitin sulfate proteoglycan to promote the site-specific accumulation of nanodrugs, whereas metformin exhibited good antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective effects.…”

Section: Functional Nanomaterials For Sci Treatmentmentioning

confidence: 99%

Recent advances in nanomaterials for the treatment of spinal cord injury

Gong

Zhang

Che

et al. 2023

Materials Today Bio

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CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury

Cited by 11 publications

References 40 publications

[Retracted] Recent Advances in Cell and Functional Biomaterial Treatment for Spinal Cord Injury

[Retracted] Recent Advances in Cell and Functional Biomaterial Treatment for Spinal Cord Injury

Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury

Recent advances in nanomaterials for the treatment of spinal cord injury

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