2024
DOI: 10.1186/s12969-024-00990-4
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CAR T cell therapy for refractory pediatric systemic lupus erythematosus: a new era of hope?

Ivana Stojkic,
Lauren Harper,
Samantha Coss
et al.

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune condition that can affect multiple organ systems and is heterogenous in its presentation and response to therapy. When diagnosed in childhood, SLE is associated with increased morbidity and mortality compared to adult SLE, often requiring substantial immunosuppression with the risk of significant side effects. There remains a significant unmet need for new therapies that can improve disease control and reduce glucocorticoid and other toxic medication e… Show more

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