CAR T-cells profiling in carcinogenesis and tumorigenesis: An overview of CAR T-cells cancer therapy

Samadani, Ali Akbar; Keymoradzdeh, Arman; Shams, Shima; Soleymanpour, Armin; Rashidy-Pour, Ali; Hashemian, Houman; Vahidi, Sogand; Norollahi, Seyedeh Elham

doi:10.1016/j.intimp.2020.107201

Cited by 17 publications

(5 citation statements)

References 59 publications

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“…Mechanisms of subcellular and tumor localization of photosensitizing agents, as well as of molecular, cellular, and tumor responses associated with photodynamic therapy in conjunction with the technical issues regarding light dosimetry, are really of great importance. Importantly, besides the PDT in cancer treatment, we strongly recommend the role of miRNAs [8] and also stem cell therapy particularly CAR-T cell therapy [6,98].…”

Section: Discussionmentioning

confidence: 99%

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Sobhani

Samadani

2021

J Egypt Natl Canc Inst

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Background Tumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular genetics methods including cell therapy, gene therapy, immunotherapy, and general cancer therapy procedures like surgery, radiotherapy, and chemotherapy, photodynamic adjuvant therapy is of great importance. Photodynamic therapy (PDT) as a relatively noninvasive therapeutic method utilizes the irradiation of an appropriate wavelength which is absorbed by a photosensitizing agent in the presence of oxygen. Main body of the abstract In this procedure, a series of events lead to the direct death of malignant cells such as damage to the microvasculature and also the induction of a local inflammatory function. PDT has participated with other treatment modalities especially in the early stage of malignant tumors and has resulted in decreasing morbidity besides improving survival rate and quality of life. High spatial resolution of PDT has attracted considerable attention in the field of image-guided photodynamic therapy combined with chemotherapy of multidrug resistance cancers. Although PDT outcomes vary across the different tumor types, minimal natural tissue toxicity, minor systemic effects, significant reduction in long-term disease, lack of innate or acquired resistance mechanisms, and excellent cosmetic effects, as well as limb function, make it a valuable treatment option for combination therapies. Short conclusion In this review article, we tried to discuss the potential of PDT in the treatment of some dermatologic and solid tumors, particularly all its important mechanisms.

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Section: Discussionmentioning

confidence: 99%

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Sobhani

Samadani

2021

J Egypt Natl Canc Inst

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“…All patients who have responded showed minimal residual disease (MRD)-negative remission on day 28 post-infusion. This ground-breaking evaluation has also demonstrated the potential that dual-targeted CAR T cells may prevent single-target loss-induced relapse [19].…”

Section: Gene Editing Approachesmentioning

confidence: 95%

Universal CAR T cell: engineering of universal T cell, modular CAR system, and applications

Duan¹,

Lin²,

Zhou³

2021

2021 International Conference on Medical Imaging, Sanitation and Biological Pharmacy (MISBP 2021)

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Universal Chimeric Antigen Receptor T cells (CAR T), an alternative design based on conventional CAR T cells, uses a switchable adaptor for a better redirection towards the target site. This technology overcomes the obstacles of the conventional Car T cells system, such as immunogenicity, massive expression of cytokine and fixed antigen specificity. This article introduces universal CAR T cells from both the perspectives of the universal T cells and its modular CAR systems, illustrating the advancement of universal CAR T cells to overcome the limitation of conventional CAR T cells and serve as a more controllable and highly promising system. The universal CAR T cells section focuses on the challenges of choosing T cell sources and the corresponding solutions, while the modular CAR system section summarizes the different types of switchable adaptors in combination with clinical applications in various types of cancer treatments. Overall, universal CAR T cells therapy is a novel development that not only out-competes but also recovers the shortage of the conventional CAR T cells system. With the use of switchable adaptors, the universal CAR T cells system is commercially beneficial for the public and a safe product to allow the industry to expand the clinical application of different types of cancers.

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“… 57 , 58 CAR-T cell therapy is a kind of immunotherapy in which, using the ability of immune cells to identify foreign agents, it is possible to kill cancerous cells without harming other normal cells in the body. 59 , 60 In general, CAR-T-cell therapy is a method of collecting immune T cells from the blood and modifying them in the laboratory to fight cancer cells and re-injecting them into the patient's body. Thereby cancer cells are identified and suppressed without harming the body's normal cells.…”

Section: Car-t Cell Therapymentioning

confidence: 99%

CRISPR, CAR-T, and NK: Current applications and future perspectives

Khoshandam,

Soltaninejad,

Hamidieh

et al. 2024

Genes & Diseases

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CAR T-cells profiling in carcinogenesis and tumorigenesis: An overview of CAR T-cells cancer therapy

Cited by 17 publications

References 59 publications

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Universal CAR T cell: engineering of universal T cell, modular CAR system, and applications

CRISPR, CAR-T, and NK: Current applications and future perspectives

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