Características clínicas e histopatológicas de ojos enucleados por melanoma uveal en un hospital terciario en España

Tirado, A. García; Durán, M. Asencio; Berjón, Alberto; Bravo-Burguillos, Elena Ruiz; Calvo, J. Peralta

doi:10.1016/j.oftal.2018.12.005

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…After the detection of metastasis, the prognosis is poor. The median survival range is between 2 to 24 months [1,2,8,28,32,34,37,39] with a median of 2.23 months in our patients. For this reason, prediction of metastasis is crucial for the patient's prognosis, and the aim of this study is to confirm the most significant risk factors for metastatic dissemination such as BAP1 mutation.…”

Section: Discussionmentioning

confidence: 96%

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Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain

Barrio

Nova-Camacho

Enériz

et al. 2021

Cancers

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Even today, the mortality rate for uveal melanoma (UM) remains very high. In our research, we sought to determine which pathological and clinical features were correlated with the prognosis of UM. BAP1 (BRCA1-Associated Protein 1) gene mutation has been analyzed as one of the strongest predictors for metastasis in UM. The BAP1 gene codifies the BAP1 protein which has a tumor suppressor function. The presence of this protein can be determined by BAP1 immunohistochemical staining. Eighty-four uveal melanoma patients and forty enucleated eyeballs were examined. Metastasis was present in 24 patients. Nuclear BAP1 staining was low in 23 patients. The presence of a higher large basal diameter tumor (p < 0.001), tumor infiltrating lymphocytes (p = 0.020), and a lack of nuclear BAP1 immunostaining (p = 0.001) ocurred significantly more often in the metastatic group. Metastasis-free survival was lower in patients with low nuclear BAP1 staining (p = 0.003). In conclusion, to the best of our knowledge, this is the first time that BAP1 staining has been studied in uveal melanoma in a Spanish community. We believe that this technique should become routine in the pathological examination of uveal melanoma in order to allow adequate classification of patients and to establish an individual follow-up plan.

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Section: Discussionmentioning

confidence: 96%

“…This is higher than the Spanish incidence rate but is quite similar to the European incidence rate [ 3 , 4 , 5 , 6 ]. Kashyap S et al noted that the incidence rate increased with age [ 27 ], the sixth and seventh decades being the most affected [ 28 ]. In our study we noted a similar increase in those patients (52.38%).…”

Section: Discussionmentioning

confidence: 99%