Características epidemiológicas según el avance de la pandemia SARS-CoV-2 en un hospital pediátrico de alta complejidad en Argentina: estudio descriptivo

Ferraro, Daiana; Arias, Ana Paula; Pérez, Guadalupe; Gomez, Sandra; Deschutter, Verónica; Highton, Esmeralda; Taicz, Moira; Trugman, Fernanda; Picollo, Micaela; Bologna, Rosa; Rosanova, María Teresa

doi:10.4067/s0716-10182021000400506

Cited by 3 publications

(4 citation statements)

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“…Deaths were rare with an estimate of 0.8% and resembled those of most studies ( 19 , 27 , 36 , 37 ). Patients with chronic illnesses such as pulmonary disease, immunodeficiencies, congenital heart disease, or neurological disease are more susceptible to death ( 22 , 23 , 38 ).…”

Section: Discussionsupporting

confidence: 71%

“…Every study reviewed, and ours, show that COVID-19 symptoms are similar to and indistinguishable from those of other common viral diseases affecting preschoolers and school-age children and comprise: fever, respiratory and gastrointestinal complaints ( 18 , 19 , 21 – 23 ). In this series, most patients suffered from acute upper respiratory infection, with a few cases of pneumonia and hypoxemia.…”

Section: Discussionmentioning

confidence: 55%

“…This high figure could be explained by the nature of our institution and the complexity of our patients, as well as our center's protocols for care and follow-up. Ferraro et al ( 19 ) in a single-center study in Argentina, found even higher admissions rates with a tally of 74.8%.…”

Section: Discussionmentioning

confidence: 89%

“…Similar results have been reported in the series from Australia (1.3%) and Argentina (4.6%). On the other hand, a Peruvian study found higher rates of severe disease with 16.8% affected with MIS-C ( 18 , 19 , 32 ). Compared with other studies, our PICU admission rate (8%) was similar to that described by Ferraro et al ( 18 – 20 , 32 , 33 ) (6.8%) and is rather average.…”

Section: Discussionmentioning

confidence: 92%

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Clinical Characteristics of Children With SARS-CoV-2 Infection in a Hospital in Latin America

et al. 2022

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Objective:COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia.MethodA descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality.ResultsA total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients).ConclusionsThe majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 92%

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Clinical Characteristics of Children With SARS-CoV-2 Infection in a Hospital in Latin America

et al. 2022

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Correlation of SARS-CoV-2 Viral Load and Clinical Evolution of Pediatric Patients in a General Hospital From Buenos Aires, Argentina

et al. 2022

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BackgroundSARS-CoV-2 infection is associated with a wide range of clinical manifestations and severity. Pediatric cases represent <10% of total cases, with a mortality rate below 1%. Data of correlation between SARS-CoV-2 viral load in respiratory samples and severity of disease in pediatric patients is scarce. The cycle threshold (CT) value for the detection of SARS-CoV-2 could be used as an indirect indicator of viral load in analyzed respiratory samples.ObjectiveThe aim of this study was to describe CT values and their correlation with clinical manifestations, epidemiology and laboratory parameters in pediatric patients with confirmed COVID-19.MethodsIn this observational, retrospective, analytic and single-center study we included patients under 15 years with confirmed COVID-19 by RT-PCR SARS-CoV-2 admitted to the Isidoro Iriarte Hospital (Argentina) between March 1st 2020 and April 30th 2021.Results485 patients were included, the distribution according to disease severity was: 84% (408 patients) presented mild disease, 12% (59 patients) moderate disease and 4% (18 patients) severe disease. Patients with moderate and severe illness had an increased hospitalization rate, prolonged hospitalization, higher frequency of comorbidities and oxygen and antibiotics use. CT values, that could be used as an indirect measure of viral load, was associated with severity of clinical manifestations and age under 12 months. No patient required admission to PICU nor mechanical ventilation. No deaths were registered.ConclusionsIn this study, the viral load of SARS-CoV-2 in respiratory samples, determined by the cycle threshold, was significantly correlated with moderate to severe cases and with age.

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Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis

Kulkarni,

Ismail,

Zhu

et al. 2024

J Glob Health

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Methods We searched MEDLINE, Embase, Global Health, CINAHL, China National Knowledge Infrastructure, Wanfang, CQvip, and the World Health Organization (WHO) COVID-19 global literature databases for primary studies recruiting children aged ≤18 years with a diagnosis of SARS-CoV-2 infection confirmed either by molecular or antigen tests. We used the Joanna Briggs Institute critical appraisal tools to appraise the study quality and conducted meta-analyses using the random effects model for all outcomes except for race/ethnicity as risk factors of SARS-CoV-2 infection. Results We included 237 studies, each reporting at least one of the study outcomes. Based on data from 117 studies, the pooled SARS-CoV-2 positivity rate was 9.30% (95% confidence interval (CI) = 7.15–11.73). Having a comorbidity was identified as a risk factor for SARS-CoV-2 infection (risk ratio (RR) = 1.33; 95% CI = 1.04–1.71) based on data from 49 studies. Most cases in this review presented with mild disease (n = 50; 52.47% (95% CI = 44.03–60.84)). However, 20.70% of paediatric SARS-CoV-2 infections were hospitalised (67 studies), 7.19% required oxygen support (57 studies), 4.26% required intensive care (93 studies), and 2.92% required assisted ventilation (63 studies). The case fatality ratio (n = 119) was 0.87% (95% CI = 0.54–1.28), which included in-hospital and out-of-hospital deaths. Conclusions Our data showed that children were at risk for SARS-CoV-2 infections and severe outcomes in the pre-Omicron era. These findings underscore the need for effective vaccination strategies for the paediatric population to protect against the acute and long-term sequelae of COVID-19. Registration PROSPERO: CRD42022327680.

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Características epidemiológicas según el avance de la pandemia SARS-CoV-2 en un hospital pediátrico de alta complejidad en Argentina: estudio descriptivo

Abstract: Sin conflictos de interés. Este estudio no recibió financiamiento.

Cited by 3 publications

References 8 publications

Clinical Characteristics of Children With SARS-CoV-2 Infection in a Hospital in Latin America

Clinical Characteristics of Children With SARS-CoV-2 Infection in a Hospital in Latin America

Correlation of SARS-CoV-2 Viral Load and Clinical Evolution of Pediatric Patients in a General Hospital From Buenos Aires, Argentina

Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis

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