Características evolutivas do Cysticercus cellulosae no encéfalo e no coração humanos

Abstract

Resumo O presente estudo teve como objetivos avaliar a prevalência de cisticercose, classificar as etapas evolutivas dos cisticercos encontrados nos encéfalos e corações humanos, diferenciá-las de acordo com os aspectos macro e microscópicos dos processos patológicos gerais e comparar os processos encontrados nos encéfalos e corações. Foram revisados protocolos de autópsias realizadas no Hospital Escola da Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brasil, no período de 1970 a 2000. Verificou-se a prevalência da cisticercose em 71 casos, sendo 18 (25,4%) de cisticercose cardíaca e 53 (74,6%) de encefálica. Foram analisados 19 cisticercos, sendo 9 de encéfalos e 10 de corações. Os cisticercos foram classificados, de acordo com sua fase evolutiva, em etapas: vesicular, vesicular coloidal, granular nodular e nodular calcificada, com similaridade entre os diagnósticos macro e microscópico. Entre os processos patológicos destacaram-se a beta-fibrilose e a fibroelastose endocárdica. Adicionalmente, demonstrou-se que a classificação pode ser aplicada tanto na cisticercose encefálica como na cardíaca. Palavras-chaves: Cisticercose cardíaca. Classificação da cisticercose. Neurocisticercose. Beta-fibrilose. AbstractThe present study aimed to evaluate the prevalence of cysticercosis, to classify the developmental phases of cysticerci found in human brains and hearts, and differentiate these according to the macro and microscopic aspects of the general pathological processes, and to compare the process found in the brains and hearts. Protocols from autopsies performed at the Hospital of the School of Medicine of the Triângulo Mineiro, Uberaba, MG, Brazil, in the period from 1970 to 2000 were reviewed. The prevalence of cysticercosis was verified in 71 cases, of which 53 (74.6%) were encephalic cysticercosis and 18 (25.3%) cardiac cysticercosis. Nineteen cysticerci were analyzed, from 9 brains and 10 hearts. The cysticerci were classified according to their developmental stage: vesicular, colloidal vesicular, granular nodular and calcified nodular, with similarities between the macroscopic and microscopic diagnoses. Among the pathological processes found beta-fibrilosis and endocardial fibroelastosis are underscored. In addition, it was demonstrated that this classification may be applied both to encephalic and cardiac cysticercosis. Key-words: Cardiac cysticercosis. Classification of cysticercosis. Encephalic cysticercosis. Beta-fibrilosis. A teníase e a cisticercose são afecções produzidas pelas fases adultas e larvárias de helmintos da família Taenidae. Existem duas espécies que afetam humanos (Taenia solium e T. saginata), que necessitam de dois hospedeiros distintos para completarem seus ciclos de vida. Os humanos são os hospedeiros definitivos para o estado adulto de ambas as espécies de tênias, enquanto os suínos e bovinos são os hospedeiros intermediários para os estágios larvários desses parasitas 11 23 . Os humanos, bovinos ou suínos se infectam ao ingerirem os ovos dos parasitas presentes em alimento...

Demyelination in experimental intraventricular neurocysticercosis

“…The pathologic processes analyzed in the brain tissues were: ventriculomegaly, polymorphonuclear cells inflammatory infiltration (PMN), mononuclear cells inflammatory infiltration (MN), foamy macrophages, meningitis, ependimitis, microgliosis (increase in the glial cellularity, especially astrocytic and microglial), and injuries in granular cells (components of the hippocampus). These pathologic processes were classified in a semi-quantitative form as follows: absente, discrete with up to 25% of area commitment, moderate with 26 to 50% of area commitment, and accentuated with more than 50% of area commitment 29 . The ventriculomegaly was analyzed in a semi-quantitative form using the same parameters described above, but using as comparison the contra-lateral non-infected ventricle from the same animal 30 .…”

Kinetics of the Inflammatory Response in Subcutaneous Cysticercosis Induced in Mice by Taenia crassiceps

“…Sections were stained with haematoxylin and eosin (HE). Serial sections were stained with picrosirius red and examined under polarized light for evaluation of fibrosis (Lino-J unior et al, 2002).…”

Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study

“…The Vesicular Stage was more prevalent among the elderly and Nodular Calcified Stage among non-elderly, and Colloidal Vesicular Stage showed higher inflammatory infiltrate in both groups. Researches show that a more intense inflammation with lymphocyte and macrophage infiltrate can be found around the cysticercus in Colloidal Vesicular Stage [ 10 , 24 , 25 ]. With cysts degenerates, the inflammatory reaction tends to decrease in the Granular Nodular Stage, denoting continuity in the host reaction against the parasite remnants without, however, having an association with the type or intensity of the inflammatory response [ 24 , 26 ].…”